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Triamterene
From WikEM
Contents
Administration
- Type: Diuretic
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Dyrenium
Adult Dosing
- Edema: 100-150 mg PO BID
- Hypertension: 50-100 mg PO daily or in 2 divided doses
Pediatric Dosing
Safety/efficacy not established
- 0.5-2 mg/kg PO BID, max daily dose 300mg
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing:
- GFR >10: use 12h dosing interval
- GFR <110 or creatinine >2.5: use not recommended
- Hepatic dosing: contraindicated in severe liver impairment
Contraindications
- Allergy to class/drug
- Anuria, severe renal dysfunction
- Hyperkalemia
- Concomitant use of antikaliuretic agents, potassium supplementation/salt substitutes, or other potassium-sparing agents
- Severe liver disease
Adverse Reactions
Serious
- Hyperkalemia
- Azotemia, nephrotoxicity
- Jaundice
- Megaloblastic anemia
- Thrombocytopenia, purpura
- Anaphylaxis
Common
- Hyperuricemia, electrolyte abnormalities
Pharmacology
- Half-life: 1.5-6.5h
- Metabolism: Hepatic
- Excretion: <50% renal
Mechanism of Action
- Potassium-sparing diuretic: inhibits epithelial sodium channel in distal renal tubule
