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Template:Adult NAC dosing
From WikEM
PO
- 140mg/kg PO load
- 70mg/kg PO q4hr x17 doses additional; dilute to 5% soln
IV
- Loading dose: 150mg/kg in 100 mL D5W over 60min
- Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr
- Third dose: 100mg/kg in 500 mL D5W over 16hr
Comments
- Almost 100% effective if given <8 hr post-ingestion; less effective if 16-24 hr post-ingestion
- May still be useful >24 hr post-ingestion, even with fulminant hepatic failure. Give NAC until LFTs improve (not until APAP level is 0) [1] [2]
- Be aware NAC treatment may affect PT. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. [3]
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