Rifaximin

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Administration

  • Type: Antibiotic
  • Dosage Forms: 200, 550
  • Routes of Administration: Oral
  • Common Trade Names: Xifaxan

Adult Dosing

  • Traveler's diarrhea, E. coli-induced: 200mg PO tid x3 days
  • Hepatic encephalopathy: 550mg PO bid
  • IBS, diarrhea-predominant: 550mg PO tid x14 days
    • May repeat dose up to 2x if recurrent disease

Pediatric Dosing

For > 12 yrs old

  • Traveler's diarrhea, E. coli-induced: 200mg PO tid x3 days

Special Populations

Renal Dosing

  • No adjustment

Hepatic Dosing

  • No adjustment

Contraindications

  • Allergy to class/drug
  • caution if hepatic impairment (Child-Pugh Class C)
  • caution if recent antibiotic-associated colitis

Adverse Reactions

Serious

  • superinfection
  • C. difficile-assoc. diarrhea
  • hypersensitivity reaction
  • angioedema
  • anaphylaxis
  • exfoliative dermatitis

Common

  • peripheral edema
  • nausea
  • dizziness
  • fatigue

Comments

See Also

References

<Epocrates, UpToDate>