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Primaquine
From WikEM
Contents
Administration
- Type: Anti-malarial, anti-PCP
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names:
Adult Dosing
- PCP pneumonia, HIV+ : 15-30mg PO daily with clindamycin
- Malaria treatment: 26.3-52.6mg PO daily in combination with an additional anti-malarial agent
- Malaria prophylaxis: 52.6mg PO daily starting 1-2 days prior to arrival in endemic area until 7-14 days after departure
Pediatric Dosing
- Malaria treatment: 0.8 mg/kg PO daily (max 52.6mg daily) in combination with an additional anti-malarial agent
- Malaria prophylaxis: 0.8 mg/kg PO daily (max 52.6mg daily) starting 1-2 days prior to arrival in endemic area until 7-14 days after departure
Special Populations
- Pregnancy Rating: D
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing:
- Hepatic dosing:
Contraindications
- Allergy to class/drug
- Concomitant use with other potentially hemolytic or myeloid suppressing drugs
- Acutely ill patients with diseases prone to granulocytopenia (e.g. SLE or rheumatoid arthritis)
Adverse Reactions
Serious
- Hemolytic anemia, leukopenia
- Methemoglobinemia
Common
- Nausea, abdominal pain
Pharmacology
- Half-life: 4-7 hours
- Metabolism:
- Excretion:
Mechanism of Action
- Eliminates tissue infection, thus preventing erythrocytic forms of parasite
