Pralidoxime

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General

  • Type:
  • Dosage Forms:
  • Common Trade Names:

Adult Dosing

Organophosphate toxicity

  • 1-2gm IV over 5-10min
  • Continuous infusion of 500mg/hr if no initial response

Pediatric Dosing

Organophosphate toxicity

  • 20-40mg/kg (up to 1gm) IV over 5-10min
  • 5-10mg/kg/hr if no initial response

Special Populations

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Tachycardia
  • Hypertension
  • Laryngospasm
  • Hepatitis

Common

Pharmacology

  • Half-life: Apparent: 74 to 77 minutes, IM/IV exposure: 3 to 4 hours
  • Metabolism: Hepatic
  • Excretion:
  • Mechanism of Action: Displaces an organophosphate from acetylcholinesterase (if given early before irreversible enzyme binding occurs, aka "aging")

Comments

See Also

Organophosphate Toxicity

References