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Oxazepam
From WikEM
Contents
Administration
- Type: Benzodiazepine
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names: Serax
Adult Dosing
- ETOH withdrawal: 15-30mg PO 3-4 times per day
- Insomnia: 15mg PO at bedtime
Pediatric Dosing
Safety/efficacy not established in children <12yo
- >12yo, ETOH withdrawal: 15-30mg PO 3-4 times per day
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: clearance may be reduced in severe liver disease
Contraindications
- Allergy to class/drug
- Psychosis
Adverse Reactions
Serious
- Withdrawal syndrome
Common
- Dizziness, vertigo
- Somnolence
- Headache
Pharmacology
- Half-life: 5.7-10.9h
- Metabolism:
- Excretion: Renal
Mechanism of Action
- Long-acting benzodiazepine, GABA-receptor agonist
