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Ipratropium
From WikEM
Contents
General
- Type: Anticholinergic Agent
- Dosage Forms: Oral inhalation
- Common Trade Names: Atrovent
Adult Dosing
Asthma: 0.5mg Nebulized q20min, up to 3 doses
COPD: 0.5mg Nebulized q20mins, up to 3 doses
Pediatric Dosing
- Children ≤5 years: 0.25mg Neb q20mins, up to 3 doses
- Children ≤12 years: 0.25-0.5mg Neb q20mins, up to 3 doses
- Children >12 years: Refer to adult dosing
Special Populations
- Pregnancy Rating: B
- Lactation risk categories: L3
- Renal Dosing - none
- Hepatic Dosing - none
Contraindications
- Allergy to anticholenergics (Atropine, Ipatropium)
- Not to be used as sole rescue agent in acute exacerbation
Adverse Reactions
Serious
- Death
Common
- Urinary retention
- Increased intraocular pressure
- Bitter taste in mouth
- Dry throat/Cough
- Nasal dryness
Pharmacology
- Half-life: 2-5hrs
- Metabolism: Possible ester hydrolysis
- Excretion: Fecal and Renal
- Mechanism of Action: Cholinergic antagonist of acetylcholine at the cholinergic receptors, causing dilatation of bronchial smooth muscle and decreased serous and seromucous glands secretion.
See Also
References
- Lexicomp
- Epocrates
- Micromedex
Authors
Andy Gausepohl, Ross Donaldson, Daniel Ostermayer, Neil Young
