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Glucarpidase
From WikEM
Contents
Administration
- Dosage Forms: 1000 units/vial
- Routes of Administration: IV
- Common Trade Names: Voraxaze
Adult Dosing
- Methotrexate toxicity
- 50 units/kg IV x1
- For patients with mod-severe renal impairment
- 50 units/kg IV x1
Pediatric Dosing
- Methotrexate toxicity
- 50 units/kg IV x1
- For patients with mod-severe renal impairment
- 50 units/kg IV x1
Special Populations
- Pregnancy Rating: C; Benefits outweigh risks during pregnancy
- Lactation risk: L3; Safety unknown
Renal Dosing
- Adult: No adjustment
- Pediatric: Not defined
Hepatic Dosing
- Adult: No adjustment
- Pediatric: Not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 5.6 hr, 8.2 hr (Crcl < 30)
- Metabolism: Unknown
- Excretion: Unknown
Mechanism of Action
- Hydrolyzes carboxyl-terminal glutamate, converting methotrexate to inactive metabolisms.
