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Captopril
From WikEM
Contents
Administration
- Type: ACE inhibitor
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 6.25-150mg PO three times per day
Pediatric Dosing
Safety/efficacy not established in pediatric patients
Special Populations
- Pregnancy Rating: D
- Lactation risk: Infant risk minimal
- Renal dosing: Initial dose should be reduced, titrate in smaller increments
Contraindications
- Allergy to class/drug
- History of ACE-inhibitor induced angioedema
Adverse Reactions
Serious
- Angioedema
- Stevens-Johnson syndrome
- Agranulocytosis, neutropenia
Common
- Hypotension
- Hyperkalemia
- Cough
- Rash
Pharmacology
- Half-life: < 3 hours
- Metabolism:
- Excretion: Renal, dialzable
Mechanism of Action
- Inhibits angiotensin I-converting enzyme, blocks conversion of angiotensin I→ angiotensin II
