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Bupropion
From WikEM
Contents
Administration
- Type: Antidepressant
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Wellbutrin, Zyban, Forfivo
Adult Dosing
- Immediate release: 100-150mg PO 2-4 times daily
- Sustained release: 150mg PO 1-2 times daily
Pediatric Dosing
Safety/efficacy not established]]
Special Populations
- Pregnancy Rating: C
- Lactation risk: infant risk cannot be ruled out
- Renal dosing: dose reduction or avoidance recommended
- Hepatic dosing: dose reduction or avoidance recommended
Contraindications
- Allergy to class/drug
- Use of MAOI, linezolid, or methylene blue concomitantly or within past 2 weeks
- Seizure disorder
- Condition which lowers seizure threshold (e.g. abrupt cessation of ETOH, benzos, or AEDs, anorexia/bulimia, electrolyte derangement)
Adverse Reactions
Serious
- Seizure
- Cardiac dysrhythmia
- Angle-closure glaucoma
- Suicidal ideation, worsening depression, mania, psychosis
Common
- Insomnia
- Dizziness, tremor
- Headache
- Nausea, constipation
- Tachyarrhythmia (10.8% )
- Pruritus, rash, urticaria
- Arthralgia, myalgia
- Tinnitus
- Xerostomia, pharyngitis
Pharmacology
- Half-life: 14-33h
- Metabolism: Hepatic, CYP2B6
- Excretion: Mostly renal
Mechanism of Action
- Exact therapeutic mechanism unknown. Weakly inhibits neuronal uptake of dopamine and norepinephrine
