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Amiloride
From WikEM
Contents
Administration
- Type: Potassium-sparing diuretic
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names: Midamor
Adult Dosing
- 5-20 mg PO daily
Pediatric Dosing
Not indicated in pediatric patients
Special Populations
- Pregnancy Rating: B
- Lactation risk:
- Renal dosing:
- Avoid if CrCl <50
- CrCl 10-50: reduce dose by 50%
- Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
- Anuria, acute or chronic renal insufficiency, diabetic nephropathy
- Hyperkalemia
- Concomitant use of antikaliuretic agents, potassium supplementation/salt substitutes, or other potassium-sparing agents
Adverse Reactions
Serious
- Hyperkalemia
- Cardiac dysrhythmia, palpitations
- Aplastic anemia, neutropenia
- Encephalopathy
- Raised intraocular pressure
Common
- Nausea/vomiting, diarrhea, loss of appetite
- Rash
- Asthenia, muscle cramps
- Cough, dyspnea
- Dizziness
- Headache
Pharmacology
- Half-life: 6-9h
- Metabolism: NOT hepatic
- Excretion: Renal, fecal
Mechanism of Action
- Potassium-sparing diuretic: inhibits epithelial sodium channel in distal renal tubule
