Acute lymphocytic leukemia

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Background

  • Characterized by proliferation of immature lymphoblast( >20% in periphery)
  • Less than 20% of acute leukemias in adults,
  • Most common form in children (see also Leukemia (Peds))
  • Highest incidence in 7th decade of life

Clinical Features

  • Lymphocytosis, neutropenia, anemia, thrombocytopenia,
  • Lymphadenopathy, hepatosplenomegaly
  • CNS and testes involvement common

Differential Diagnosis

Acute Leukemia/Lymphoma

Evaluation

  • CXR
  • CBC with peripheral smear
  • Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
  • LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
  • ESR, CRP
  • Reticulocyte count in anemia
  • Get extra purple top for flow cytometry, especially before transfusion

Treatment

See Also

References