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Antimicrobial Resistance Susceptibility Testing Gonorrhea Laboratory Information Gonorrhea Sexually Transmitted Diseases

2013 Interpretive Criteria for Neisseria gonorrhoeae Susceptibility Testing

The following are zone diameter interpretive standards and equivalent minimal inhibitory concentration (MIC) breakpoints* for Neisseria gonorrhoeae according to the Clinical and Laboratory Standards Institute (Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Third Informational Supplement, January 2013, M100-S23 Vol 33 No 1::

*At this time, no interpretive criteria exists for Azithromycin and Levofloxacin

Antimicrobial AgentZone Diameter
(nearest whole mm)		Equivalent MIC Breakpoints
(µg/mL)
RISRS

Penicillins

Penicillin<=2627-46>=47>=2<=0.06

Cephems (Parenteral)

Cefotaxime-->=31-<=0.5
Ceftizoxime-->=38-<=0.5
Ceftriaxone-->=35-<=0.25

Cefmetazole

<=2728-32>=33>=8<=2
Cefotetan<=1920-25>=26>=8<=2
Cefoxitin<=2324-27>=28>=8<=2
Cefuroxime sodium (parenteral)<=2526-30>=31>=4<=1

Cefepime

-->=31-<=0.5

Ceftazidime

-->=31-<=0.5

Cephems (Oral)

Cefixime-->=31-<=0.25

Cefpodoxime

-->=29-<=0.5

Cefetamet

-->=29-<=0.5

Tetracyclines

Tetracycline

<=3031-37>=38>=2<=0.25

Fluoroquinolones

Ciprofloxacin

<=2728-40>=41>=1<=0.06
Gatifloxacin<=3334-37>=38>=0.5<=0.12
Ofloxacin<=2425-30>=31>=2<=0.25

Enoxacin

<=3132-35>=36>=2<=0.5

Grepafloxacin

<=2728-36>=37>=1<=0.06

Lomefloxacin

<=2627-37>=38>=2<=0.12

Trovafloxacin

-->=34-<=0.25

Fleroxacin

<=2829-34>=35>=1<=0.25

Aminocyclitols

Spectinomycin

<=1415-17>=18>=128<=32

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