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NIOSH

ETHYLBIS(2-CHLOROETHYL)AMINE

ICSC: 1655

Bis(2-chloroethyl)ethylamine
2-Chloro-N-(2-chloroethyl)-N-ethylethanamine
2-Chloro-N-(2-chloroethyl)-N-ethyl-ethanamine
2,2'-Dichloro-triethylamine
HN1
Nitrogen Mustard
C6H13Cl2N / (ClCH2CH2)2NC2H5
Molecular mass: 170.1
ICSC # 1655 		CAS # 538-07-8
RTECS # YE1225000
UN # 2810
April 10, 2008 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Heating will cause rise in pressure with risk of bursting. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray , alcohol-resistant foam , carbon dioxide , powder .
EXPLOSION

In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Sore throat. Burning sensation. Cough. Tremor. Loss of movement co-ordination. Convulsions. Laboured breathing. Shortness of breath. Wheezing. Symptoms may be delayed (see Notes).
Closed system.
Half-upright position. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention.
•SKIN MAY BE ABSORBED! Redness. Pain. Blisters. These may be delayed. (Further see Inhalation).
Protective gloves. Protective clothing.
Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.
•EYES VAPOUR WILL BE ABSORBED! Causes watering of the eyes. Redness. Pain. Spasms, photophobia and dilated pupils . Blurred vision. Severe deep burns. Loss of vision.
Safety goggles . Face shield or eye protection in combination with breathing protection.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
•INGESTION Sore throat. Abdominal pain. Burning sensation in the throat and chest. Nausea. Vomiting. Diarrhoea. (Further see Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention. See Notes.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Evacuate danger area immediately! Consult an expert! Gas-tight chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in sealable air tight containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. NEVER direct water jet on liquid. Do NOT let this chemical enter the environment.
Keep in the dark. Separated from food and feedstuffs and metals . Keep in a well-ventilated room. Store in an area without drain or sewer access.
Do not transport with food and feedstuffs.
UN Hazard Class: 6.1
UN Packing Group: I
Signal: Danger
Skull-Corr-Health haz
Fatal if inhaled
Fatal in contact with skin
Causes skin irritation
Causes serious eye damage
May cause genetic defects
May cause cancer
Causes damage to nervous system and bone marrow
May cause respiratory irritation
Causes damage to nervous system and bone marrow through prolonged or repeated exposure
ICSC: 1655 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

ETHYLBIS(2-CHLOROETHYL)AMINE

ICSC: 1655

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PHYSICAL STATE; APPEARANCE:
COLOURLESS , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance will polymerize under the influence of heat and light . Attacks many metals forming flammable/explosive gas (hydrogen - see ICSC 0001).

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
MAK not established.


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol, through the skin, and by ingestion . Serious local effects and systemic effects by all routes of exposure .

INHALATION RISK:
A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

EFFECTS OF SHORT-TERM EXPOSURE:
Blistering agent. Lachrymation. The substance is severely irritating to the eyes, the skin and the respiratory tract . The substance may cause effects on the central nervous system and bone marrow . Inhalation of the substance may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the bone marrow and central nervous system . This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. See Notes.

PHYSICAL
PROPERTIES

Decomposes at 194 °C
Melting point: -34°C
Relative density (water = 1): 1.09
g/cm3
Solubility in water, g/100 ml: (very poor)
at 25°C
Vapour pressure, kPa at 25°C: 0.03
Relative vapour density (air = 1): 5.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00

ENVIRONMENTAL
DATA

No data available.

N O T E S

Do NOT take working clothes home. Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation is therefore essential. Because many of the effects resemble those of ionizing radiation, the term radiomimetic is frequently used.
Transport Emergency Card: TEC (R)-61GT1-I

NFPA Code: H4; F2; R0;

ADDITIONAL INFORMATION



ICSC: 1655 ETHYLBIS(2-CHLOROETHYL)AMINE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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