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NIOSH

n-BUTYL ISOCYANATE

ICSC: 1642

1-Isocyanatobutane
C5H9NO / CH3(CH2)3NCO
Molecular mass: 99.1
ICSC # 1642 		CAS # 111-36-4
RTECS # NQ8250000
UN # 2485
April 19, 2007 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Highly flammable. Heating will cause rise in pressure with risk of bursting.
NO open flames, NO sparks, and NO smoking.
Dry powder. Foam. Carbon dioxide. NO water .
EXPLOSION Vapour/air mixtures are explosive.
Closed system, ventilation, explosion-proof electrical equipment and lighting.
In case of fire: cool drums, etc., by spraying with water but avoid contact of the substance with water. Combat fire from a sheltered position.
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Cough. Sore throat. Laboured breathing. Burning sensation.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
•SKIN Redness. Pain. Skin burns.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
•EYES Redness. Pain. Burns .
Safety goggles or eye protection in combination with breathing protection.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
•INGESTION Abdominal pain. Burning sensation. Shock or collapse.
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Evacuate danger area! Ventilation. Remove all ignition sources. Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. Do NOT let this chemical enter the environment.
Fireproof. Separated from strong oxidants, food and feedstuffs. Cool. See Chemical Dangers. Store in an area without drain or sewer access.
Do not transport with food and feedstuffs.
UN Hazard Class: 6.1
UN Subsidiary Risks: 3
UN Packing Group: I
Signal: Danger
Flame-Corr-Skull-Health haz
Highly flammable liquid and vapour
Fatal if inhaled (vapour)
Harmful if swallowed
Catches fire spontaneously if exposed to air
May cause allergic skin reaction
Causes damage to lungs if inhaled
ICSC: 1642 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

n-BUTYL ISOCYANATE

ICSC: 1642

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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID

PHYSICAL DANGERS:
The vapour mixes well with air, explosive mixtures are formed easily.

CHEMICAL DANGERS:
The substance may polymerize due to heating . The substance decomposes on burning producing toxic gases including nitrogen oxides , hydrogen cyanide . Reacts violently with strong oxidants and water .

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
MAK not established.


ROUTES OF EXPOSURE:
Serious local effects by all routes of exposure.

INHALATION RISK:
A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the eyes, the skin and the respiratory tract. Inhalation may cause lung oedema (see Notes).

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. See Notes.

PHYSICAL
PROPERTIES

Boiling point: 115°C
Melting point: <-70°C
Density: 0.9
g/cm3
Solubility in water, g/100 ml: (reaction)
Vapour pressure, kPa at 20°C: 2.1
Relative vapour density (air = 1): 3.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05
Flash point: 11°C c.c
Auto-ignition temperature: 425°C
Explosive limits, vol% in air: 1.3-10

ENVIRONMENTAL
DATA

This substance may be hazardous in the environment; special attention should be given to aquatic organisms.

N O T E S

Some isocyanates are well known to cause respiratory sensitization. However, there are no reports of n-butyl isocyanate or other monoisocyanates causing respiratory sensitization. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation is therefore essential.
Transport Emergency Card: TEC (R)- 61S2485 or 61GTF1-I

NFPA Code: H3; F3; R2; W

ADDITIONAL INFORMATION



ICSC: 1642 n-BUTYL ISOCYANATE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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