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NIOSH

CHLORPYRIFOS

ICSC: 0851

O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothioate
O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioic acid ester
Chlorpyrifos-ethyl
C9H11Cl3NO3PS
Molecular mass: 350.6
ICSC # 0851 		CAS # 2921-88-2
RTECS # TF6300000
UN # 2783
EC # 015-084-00-4
October 19, 2005 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray, foam, powder, carbon dioxide.
EXPLOSION


EXPOSURE
STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Pupillary constriction, muscle cramp, excessive salivation. Sweating. Dizziness. Nausea. Vomiting. Diarrhoea. Muscle twitching. Convulsions. Unconsciousness.
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
•SKIN MAY BE ABSORBED! (See Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES Blurred vision.
Face shield or eye protection in combination with breathing protection if powder.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION (See Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give a slurry of activated charcoal in water to drink. Refer for medical attention immediately.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place.
Store in an area without drain or sewer access. Keep in a well-ventilated room. Separated from strong bases, strong acids, food and feedstuffs .
Do not transport with food and feedstuffs.
Severe
marine pollutant.
T symbol
N symbol
R: 25-50/53
S: 1/2-45-60-61
UN Hazard Class: 6.1
UN Packing Group: III
ICSC: 0851 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

CHLORPYRIFOS

ICSC: 0851

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D

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A

PHYSICAL STATE; APPEARANCE:
COLOURLESS TO WHITE CRYSTALS , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating at approximately 160°C producing toxic and corrosive fumes including hydrogen chloride , phosgene , phosphorus oxides , nitrogen oxides , sulfur oxides . Reacts with strong bases , acids .

OCCUPATIONAL EXPOSURE LIMITS:
TLV: (Inhalable vapour and aerosol) 0.1 mg/m3 as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2005).
MAK not established.
OSHA PEL†: none
NIOSH REL: TWA 0.2 mg/m3 ST 0.6 mg/m3 skin
NIOSH IDLH: N.D. See: IDLH INDEX


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin, and by ingestion.

INHALATION RISK:
A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the nervous system , resulting in convulsions and respiratory depression . Cholinesterase inhibition. Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.

PHYSICAL
PROPERTIES

Decomposes below boiling point at 160°C
Melting point: 41-42°C
Density: 1.4
g/cm3
Solubility in water: 1.4 mg/l
(very poor)
Vapour pressure, Pa at 25°C: 0.0024
Octanol/water partition coefficient as log Pow: 4.7-5.27

ENVIRONMENTAL
DATA

The substance is very toxic to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to birds and honey bees. Bioaccumulation of this chemical may occur along the food chain, for example in fish and algae. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.

N O T E S

If the pesticide is present in a formulation containing hydrocarbon solvents, vomiting should not be induced. Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. If the substance is formulated with solvents also consult the ICSCs of these materials. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home.
Transport Emergency Card: TEC (R)-61GT7-III

ADDITIONAL INFORMATION



ICSC: 0851 CHLORPYRIFOS
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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