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NIOSH

NICOTINE

ICSC: 0519

(S)-3-(1-Methylpyrrolidin-2-yl)pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
beta-Pyridyl-alpha-N-methylpyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
C10H14N2
Molecular mass: 162.2
ICSC # 0519 		CAS # 54-11-5
RTECS # QS5250000
UN # 1654
EC # 614-001-00-4
September 04, 1997 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 95°C explosive vapour/air mixtures may be formed.
Above 95°C use a closed system, ventilation.

EXPOSURE
PREVENT GENERATION OF MISTS! AVOID EXPOSURE OF (PREGNANT) WOMEN!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Burning sensation. Nausea. Vomiting. Convulsions. Abdominal pain. Diarrhoea. Headache. Sweating. Weakness. Dizziness. Confusion.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
•SKIN MAY BE ABSORBED! Redness. Burning sensation. (See Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES Pain. Redness.
Safety goggles , face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION (See Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Give a slurry of activated charcoal in water to drink. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. (Extra personal protection: complete protective clothing including self-contained breathing apparatus).
Provision to contain effluent from fire extinguishing. Separated from strong oxidants, food and feedstuffs. Dry. Ventilation along the floor.
Do not transport with food and feedstuffs.
T+ symbol
N symbol
R: 25-27-51/53
S: 1/2-36/37-45-61
UN Hazard Class: 6.1
UN Packing Group: II
ICSC: 0519 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

NICOTINE

ICSC: 0519

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PHYSICAL STATE; APPEARANCE:
OILY, COLOURLESS HYGROSCOPIC LIQUID , WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes including nitrogen oxides and carbon monoxide. Reacts violently with strong oxidants.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.5 mg/m3 (as TWA), (skin) (ACGIH 1996).
EU OEL: 0.5 mg/m3 as TWA, (skin) (EU 2006).
OSHA PEL: TWA 0.5 mg/m3 skin
NIOSH REL: TWA 0.5 mg/m3 skin
NIOSH IDLH: 5 mg/m3 See: 54115


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin, and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes and the skin. The substance may cause effects on the cardiovascular system and central nervous system , resulting in convulsions and respiratory failure. Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Animal tests show that this substance possibly causes toxic effects upon human reproduction.

PHYSICAL
PROPERTIES

Boiling point (decomposes): 247°C
Melting point: -80°C
Relative density (water = 1): 1.01
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 0.006
Relative vapour density (air = 1): 5.6
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 95°C c.c.
Auto-ignition temperature: 240°C
Explosive limits, vol% in air: 0.7-4
Octanol/water partition coefficient as log Pow: 1.2

ENVIRONMENTAL
DATA

The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use.

N O T E S

Destruxol, XL All Insecticide are trade names.
Transport Emergency Card: TEC (R)-61G68

NFPA Code: H4; F1; R0;
Card has been partially updated in August 2007: see Ingestion First Aid, Occupational Exposure Limits

ADDITIONAL INFORMATION



ICSC: 0519 NICOTINE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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