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NIOSH

METHYL ISOBUTYL KETONE

ICSC: 0511

4-Methyl-2-pentanone
Isopropylacetone
Hexone
C6H12O / CH3COCH2CH(CH3)2
Molecular mass: 100.2
ICSC # 0511 		CAS # 108-10-1
RTECS # SA9275000
UN # 1245
EC # 606-004-00-4
July 10, 1997 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Highly flammable.
NO open flames, NO sparks, and NO smoking.
Powder, AFFF, foam, carbon dioxide.
EXPLOSION Vapour/air mixtures are explosive.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT GENERATION OF MISTS!

•INHALATION Cough. Diarrhoea. Dizziness. Headache. Nausea. Sore throat. Unconsciousness. Vomiting. Weakness. Loss of appetite.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
•SKIN Dry skin. Redness. Pain.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
•EYES Redness. Pain.
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal pain. (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: filter respirator for organic gases and vapours.
Fireproof. Separated from strong oxidants. Well closed.
Airtight.
Note: 6
F symbol
Xn symbol
R: 11-20-36/37-66
S: 2-9-16-29
UN Hazard Class: 3
UN Packing Group: II
ICSC: 0511 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

METHYL ISOBUTYL KETONE

ICSC: 0511

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A

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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The vapour mixes well with air, explosive mixtures are easily formed.

CHEMICAL DANGERS:
The substance can form explosive peroxides upon exposure to air. Reacts violently with strong oxidants and strong reducing agents .

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 50 ppm as TWA; 75 ppm as STEL; BEI issued; (ACGIH 2004).
MAK: 20 ppm, 83 mg/m3; H;
Peak limitation category: I(2); Pregnancy risk group: C;
(DFG 2004).
OSHA PEL†: TWA 100 ppm (410 mg/m3)
NIOSH REL: TWA 50 ppm (205 mg/m3) ST 75 ppm (300 mg/m3)
NIOSH IDLH: 500 ppm See: 108101


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance and the vapour is irritating to the eyes , the skin and the respiratory tract . Swallowing the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis. The substance may cause effects on the central nervous system at high concentrations , resulting in narcosis.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis.

PHYSICAL
PROPERTIES

Boiling point: 117-118°C
Melting point: -84.7°C
Relative density (water = 1): 0.80
Solubility in water, g/100 ml at 20°C: 1.91
Vapour pressure, kPa at 20°C: 2.1
Relative vapour density (air = 1): 3.45
Flash point: 14°C c.c.
Auto-ignition temperature: 460°C
Explosive limits, vol% in air: 1.4-7.5
Octanol/water partition coefficient as log Pow: 1.38

ENVIRONMENTAL
DATA


N O T E S

MIBK is commonly used name. Check for peroxides prior to distillation; eliminate if found. Card has been partly updated in October 2004. See sections Occupational Exposure Limits, EU classification, Emergency Response.
Transport Emergency Card: TEC (R)-30S1245

NFPA Code: H2; F3; R0;

ADDITIONAL INFORMATION



ICSC: 0511 METHYL ISOBUTYL KETONE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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