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NIOSH

2-HEXANONE

ICSC: 0489

Methyl n-butyl ketone
n-Butyl methyl ketone
MBK
C6H12O / C4H9COCH3
Molecular mass: 100.2
ICSC # 0489 		CAS # 591-78-6
RTECS # MP1400000
UN # 1224
EC # 606-030-00-6
November 24, 1998 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Flammable.
NO open flames, NO sparks, and NO smoking.
Alcohol-resistant foam, powder, carbon dioxide.
EXPLOSION Above 23°C explosive vapour/air mixtures may be formed.
Above 23°C use a closed system, ventilation, and explosion-proof electrical equipment.
In case of fire: keep cylinder cool by spraying with water.
EXPOSURE


•INHALATION Cough. Drowsiness. Headache. Nausea. Sore throat.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
•SKIN MAY BE ABSORBED! Dry skin.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES Redness. Pain. Blurred vision.
Face shield, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal pain. Diarrhoea. Sore throat. (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: self-contained breathing apparatus).
Fireproof. Separated from strong oxidants.

Note: 6
T symbol
R: 10-48/23-62-67
S: 1/2-36/37-45
UN Hazard Class: 3
UN Packing Group: III
ICSC: 0489 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

2-HEXANONE

ICSC: 0489

I

M

P

O

R

T

A

N

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D

A

T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
Reacts violently with oxidants causing fire and explosion hazard. Attacks plastics.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 5 ppm as TWA; 10 ppm as STEL; (skin); BEI issued (ACGIH 2006).
MAK: 5 ppm, 21 mg/m3;
Peak limitation category: II(8);
skin absorption (H); (DFG 2006).
OSHA PEL†: TWA 100 ppm (410 mg/m3)
NIOSH REL: TWA 1 ppm (4 mg/m3)
NIOSH IDLH: 1600 ppm See: 591786


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, and through the skin.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying or dispersing much faster.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes and the respiratory tract. The substance may cause effects on the nervous system. Exposure far above the OEL may result in unconsciousness.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the nervous system.

PHYSICAL
PROPERTIES

Boiling point: 126-128°C
Melting point: -57°C
Relative density (water = 1): 0.8
Solubility in water, g/100 ml at 20°C: 1.4
Vapour pressure, kPa at 20°C: 0.36
Relative vapour density (air = 1): 3.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 23°C (c.c.)
Auto-ignition temperature: 423°C
Explosive limits, vol% in air: 1.2-8.0
Octanol/water partition coefficient as log Pow: 1.38

ENVIRONMENTAL
DATA


N O T E S

Use of alcoholic beverages enhances the harmful effect. MBK potentiates the toxicity of some other chemical substances like chloroform, carbon tetrachloride, ethanol. Depending on the degree of exposure, periodic medical examination is indicated.
Transport Emergency Card: TEC (R)-30G35

NFPA Code: H 2; F 3; R 0.
Card has been partially updated in July 2007: see Occupational Exposure Limits, EU Classification, Fire fighting.

ADDITIONAL INFORMATION



ICSC: 0489 2-HEXANONE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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