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NIOSH

GLYCIDOL

ICSC: 0159

2,3-Epoxy-1-propanol
Oxirane methanol
3-Hydroxypropylene oxide
C3H6O2
Molecular mass: 74.1
ICSC # 0159 		CAS # 556-52-5
RTECS # UB4375000
UN # 2810
EC # 603-063-00-8
October 18, 2005 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible.
NO open flames. NO contact with incompatible materials (see Chemical Dangers).
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 72°C explosive vapour/air mixtures may be formed.
Above 72°C use a closed system, ventilation.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
AVOID ALL CONTACT! AVOID EXPOSURE OF (PREGNANT) WOMEN!

•INHALATION Cough. Sore throat. Dizziness. Drowsiness.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
•SKIN MAY BE ABSORBED! Redness.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
•EYES Redness. Pain.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal pain. Diarrhoea. Nausea. Vomiting.
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable glass or mild steel containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place.
Store only if stabilized. Cool. Dry. Well closed. Ventilation along the floor. Separated from strong bases, strong acids, food and feedstuffs .
Do not transport with food and feedstuffs.
T symbol
R: 45-60-21/22-23-36/37/38-68
S: 53-45
UN Hazard Class: 6.1
UN Packing Group: III
ICSC: 0159 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

GLYCIDOL

ICSC: 0159

I

M

P

O

R

T

A

N

T


D

A

T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS SLIGHTLY VISCOUS LIQUID

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance may polymerize. The substance decomposes on contact with strong acids and bases, metal salts or metals , causing fire and explosion hazard. Attacks plastic and rubber.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 2 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2005).
MAK: skin absorption (H);
Carcinogen category: 2;
(DFG 2005).
OSHA PEL†: TWA 50 ppm (150 mg/m3)
NIOSH REL: TWA 25 ppm (75 mg/m3)
NIOSH IDLH: 150 ppm See: 556525


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes , the skin and the respiratory tract . The substance may cause effects on the central nervous system . Exposure far above the OEL could cause lowering of consciousness.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
This substance is probably carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

PHYSICAL
PROPERTIES

Boiling point (decomposes): 166°C
Melting point: -45°C
Relative density (water = 1): 1.1
Solubility in water:
miscible
Vapour pressure, Pa at 25°C: 120
Relative vapour density (air = 1): 2.15
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 72°C c.c.
Auto-ignition temperature: 415°C
Octanol/water partition coefficient as log Pow: -0.95

ENVIRONMENTAL
DATA


N O T E S

Depending on the degree of exposure, periodic medical examination is suggested. Environmental effects from the substance have not been investigated adequately. Other CAS numbers for the optical active forms are: d-Glycidol CAS 57044-25-4, l-Glycidol CAS 60456-23-7, dl-Glycidol CAS 61915-27-3.
Transport Emergency Card: TEC (R)-61GT1-III.

ADDITIONAL INFORMATION



ICSC: 0159 GLYCIDOL
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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