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NIOSH

ETHYLENE OXIDE

ICSC: 0155

1,2-Epoxyethane
Oxirane
Dimethylene oxide
C2H4O
Molecular mass: 44.1
(cylinder)
ICSC # 0155 		CAS # 75-21-8
RTECS # KX2450000
UN # 1040
EC # 603-023-00-X
October 18, 2001 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Extremely flammable.
NO open flames, NO sparks, and NO smoking.
Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out; in other cases extinguish with powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Gas/air mixtures are explosive. Risk of fire and explosion as a result of violent decomposition when heated.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Use non-sparking handtools.
In case of fire: keep cylinder cool by spraying with water. Combat fire from a sheltered position.
EXPOSURE
STRICT HYGIENE! AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Cough. Drowsiness. Headache. Nausea. Sore throat. Vomiting. Weakness.
Closed system and ventilation.
Fresh air, rest. Refer for medical attention.
•SKIN ON CONTACT WITH LIQUID: FROSTBITE. Dry skin. Redness. Pain.
Protective gloves. Cold-insulating gloves. Protective clothing.
Remove contaminated clothes. ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
•EYES Redness. Pain. Blurred vision.
Eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION
Do not eat, drink, or smoke during work. Wash hands before eating.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Evacuate danger area! Consult an expert! Ventilation. NEVER direct water jet on liquid. Remove gas with fine water spray. Do NOT wash away into sewer. Gas-tight chemical protection suit including self-contained breathing apparatus.
Fireproof. Cool.

Note: E
F+ symbol
T symbol
R: 45-46-12-23-36/37/38
S: 53-45
UN Hazard Class: 2.3
UN Subsidiary Risks: 2.1
ICSC: 0155 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

ETHYLENE OXIDE

ICSC: 0155

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PHYSICAL STATE; APPEARANCE:
COLOURLESS COMPRESSED LIQUEFIED GAS , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The gas is heavier than air and may travel along the ground; distant ignition possible.

CHEMICAL DANGERS:
The substance may polymerize due to heating, under the influence of acid(s), base(s), metal chlorides and metal oxides with fire or explosion hazard. The substance decomposes in the absence of air on heating above 560°C , causing fire and explosion hazard. Reacts violently with many compounds.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 1 ppm as TWA; A2 (suspected human carcinogen); (ACGIH 2004).
MAK: skin absorption (H);
Carcinogen category: 2; Germ cell mutagen group: 2;
(DFG 2004).
OSHA PEL: 1910.1047 TWA 1 ppm 5 ppm 15-minute Excursion
NIOSH REL: Ca TWA <0.1 ppm (0.18 mg/m3) C 5 ppm (9 mg/m3) 10-min/day See Appendix A
NIOSH IDLH: Ca 800 ppm See: 75218


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin in water solution.

INHALATION RISK:
A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

EFFECTS OF SHORT-TERM EXPOSURE:
The vapour is irritating to the eyes , the skin and the respiratory tract . Water solution may cause skin blisters. Rapid evaporation of the liquid may cause frostbite.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma. The substance may have effects on the nervous system. This substance is carcinogenic to humans. May cause heritable genetic damage to human germ cells.

PHYSICAL
PROPERTIES

Boiling point: 11°C
Melting point: -111°C
Relative density (water = 1): 0.9
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 146
Relative vapour density (air = 1): 1.5
Flash point: Flammable Gas
Auto-ignition temperature: 429°C
Explosive limits, vol% in air: 3-100
Octanol/water partition coefficient as log Pow: -0.3

ENVIRONMENTAL
DATA

The substance is harmful to aquatic organisms.

N O T E S

Turn leaking cylinder with the leak up to prevent escape of gas in liquid state. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. The odour warning when the exposure limit value is exceeded is insufficient. Card has been partly updated in April 2005. See sections Occupational Exposure Limits, Emergency Response.
Transport Emergency Card: TEC (R)-20S1040 or 20GTF

NFPA Code: H2; F4; R3

ADDITIONAL INFORMATION



ICSC: 0155 ETHYLENE OXIDE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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