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NIOSH

2-CHLOROACETOPHENONE

ICSC: 0128

2-Chloro-1-phenylethanone
alpha-Chloroacetophenone
Phenacyl chloride
C8H7ClO / C6H5COCH2Cl
Molecular mass: 154.6
ICSC # 0128 		CAS # 532-27-4
RTECS # AM6300000
UN # 1697
August 10, 2002 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION

In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
STRICT HYGIENE!

•INHALATION Burning sensation. Cough. Sore throat. Nausea. Shortness of breath.
Local exhaust or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
•SKIN Redness. Pain.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES Redness. Pain. Blurred vision. Permanent partial loss of vision.
Safety spectacles, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Burning sensation.
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give plenty of water to drink. Give a slurry of activated charcoal in water to drink. Refer for medical attention. Rest.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Sweep spilled substance into sealable, plastic containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: self-contained breathing apparatus.)
Separated from food and feedstuffs . Keep in a well-ventilated room.
Do not transport with food and feedstuffs.
UN Hazard Class: 6.1
UN Packing Group: II
ICSC: 0128 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

2-CHLOROACETOPHENONE

ICSC: 0128

I

M

P

O

R

T

A

N

T


D

A

T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS TO GREY CRYSTALS.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on burning producing toxic and corrosive fumes including hydrogen chloride .

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.05 ppm; A4; (ACGIH 2002).
OSHA PEL: TWA 0.3 mg/m3 (0.05 ppm)
NIOSH REL: TWA 0.3 mg/m3 (0.05 ppm)
NIOSH IDLH: 15 mg/m3 See: 532274


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and by ingestion.

INHALATION RISK:
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
Causes watering of the eyes. The substance is severely irritating to the eyes . The substance is irritating to the skin and the respiratory tract . Inhalation of vapour or aerosol may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.

PHYSICAL
PROPERTIES

Boiling point: 244-245°C
Melting point: 54-59°C
Density: 1.3
g/cm3
Solubility in water, g/100 ml at 25°C: 1.64
Vapour pressure, Pa at 20°C: 0.7
Relative vapour density (air = 1): 5.3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 118°C c.c.
Octanol/water partition coefficient as log Pow: 2.08

ENVIRONMENTAL
DATA


N O T E S

The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. The odour warning when the exposure limit value is exceeded is insufficient. Chemical Mace, CAP, CN are trade names. Do NOT take working clothes home.
Transport Emergency Card: TEC (R)-61GT2-II

NFPA Code: H 2; F 1; R 0;

ADDITIONAL INFORMATION



ICSC: 0128 2-CHLOROACETOPHENONE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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