Dibutyl phthalate

CAS number: 84–74–2

NIOSH REL: 5 mg/m³ TWA

Current OSHA PEL: 5 mg/m³ TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 5 mg/m³ TWA

Description of Substance: Colorless to faint-yellow, oily liquid with a slight, aromatic odor.

LEL(@456 F): 0.5% (10% LEL(@456 F), 32,700 mg/m³)

Original (SCP) IDLH: 9,300 mg/m³

Basis for original (SCP) IDLH: Because dibutylphthalate has a very low toxicity, the available toxicological data contains no evidence of an IDLH for it. Therefore, the chosen IDLH is based on an analogy with dimethylphthalate, which has an IDLH of 9,300 mg/m³.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50	LCLo	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rat Mouse	Antonyuk and Aldyreva 1973 Izmerov et al. 1982	4,250 mg/m3 25,000 mg/m3	----- -----	? 2 hr	? 40,000 mg/m3 (1.6)	? 4,000 mg/m3

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Mouse Rat G. pig	Antonyuk 1963 Sine 1993 Timofeevskaia et al. 1980	oral oral oral	5,289 8,000 10,000	----- ----- -----	37,023 mg/m3 56,000 mg/m3 70,000 mg/m3	3,702 mg/m3 5,600 mg/m3 7,000 mg/m3

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 4,000 mg/m3 Basis for revised IDLH: The revised IDLH for dibutyl phthalate is 4,000 mg/m3 based on acute inhalation toxicity data in animals [Izmerov et al. 1982]. [Note: Due to its low volatility, this concentration could only be reached at elevated temperatures or if the liquid droplets become airborne as in a mist.]

REFERENCES:

1. Antonyuk OK [1963]. About the toxicity of didodecylphthalate. Gig Tr Prof Zabol 17(11):51-52 (in Russian).

2. Antonyuk OK, Aldyreva MV [1973]. Substantiation of maximum permissible concentration of dibutyl phthalate in the air of industrial premises. Gig Tr Prof Zabol 17(8):26-30 (in Russian).

3. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 44.

4. Sine C, ed. [1993]. Dibutyl phthalate. In: Farm chemicals handbook '93, p. C112.

5. Timofeevskaia LA, Ivanova NI, Baliniva ES [1980]. Toxicology of o-phthalic acid and esters and hygienic regimentation. Gig Tr Prof Zabol 24(3):25-27 (in Russian).