Ammonium sulfamate

CAS number: 7773-06-0

NIOSH REL: 10 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA

Current OSHA PEL:15 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA

1989 OSHA PEL: 10 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA

1993-1994 ACGIH TLV 10 mg/m3 TWA

Description of substance: Colorless to white crystalline, odorless solid.

LEL: Noncombustible Solid

Original (SCP) IDLH: 5,000 mg/m3

Basis for original (SCP) IDLH: The chosen IDLH is based on the rat intraperitoneal LDLO of 800 mg/kg cited by NIOSH [1976] from Ambrose [1943]. This compound has a low toxicity.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal dose data:

Species	Reference	Route	LD50(mg/kg)	LDLo(mg/kg)	Adjusted LD	Derived Value
Rat	Ball 1956	oral	2,000	-----	14,000 mg/m3	1,400 mg/m3
Mouse	Gig Tr Prof Zabol 1963	oral	3,100	-----	21,700 mg/m3	2,170 mg/m3
Rat	Lehman 1951	oral	3,900	-----	27,300 mg/m3	2,730 mg/m3
Mouse	Lehman 1951	oral	5,760	-----	40,320 mg/m3	4,032 mg/m3

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 1,500 mg/m3 Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for ammonium sulfamate. Therefore, the revised IDLH for ammonium sulfamate is 1,500 mg/m3 based on the acute oral toxicity data in animals [Ball 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCES:

1. Ambrose AM [1943]. Studies of the physiological effects of sulfamic acid and ammonium sulfamate. J Ind Hyg Toxicol 25:26.
2. Ball WL [1956]. Threshold limits for pesticides. AMA Arch Ind Health 14:178-185.
3. Gig Tr Prof Zabol [1963]; 7(5):56-57 (in Russian).
4. Lehman AJ [1951]. Chemicals in foods: a report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Q Bulletin Assoc Food Drug Off U.S. 15(4):122-125.
5. NIOSH [1976]. WO61250. Sulfamic acid, monoammonium salt. In: Registry of Toxic Effects of Chemical Substances (RTECS) 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 1111.