Dinitro-o-cresol

CAS number; 534-52-1

NIOSH REL: 0.2 mg/m³ TWA [skin]

Current OSHA PEL: 0.2 mg/m³ TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.2 mg/m³ TWA [skin]

Description of Substance: Yellow, odorless solid.

LEL:. . Unknown

Original (SCP) IDLH: 5 mg/m³

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Hunter [1969] that 4.7 mg/m³ per day caused the following symptoms in a factory worker: fever, weight loss, a 400% rise in the basal rate of metabolism, rapid pulse, rapid respiration, profuse sweating, shortness of breath, and cough [McDonald 1943]. It is obvious that the chosen IDLH has been set conservatively, but no other quantitative data are available on which to base an IDLH.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50	LCLo	Time	Adjusted 0.5-hr LC (CF)	Derived value
Cat	Burkatskaya 1965	LC33: 40 mg/m3	-----	4 hr	80 mg/m3 (2.0)	8.0 mg/m3

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rat Cat Mouse Rabbit G. pig Rat	Colliot 1972 DeCeaurriz et al. 1981 MacEwen and Vernot 1972 Popov and Vrochinsky 1976 Popov and Vrochinsky 1976 Spencer et al. 1948	oral oral oral oral oral oral	7 50 21 24.6 24.6 31	----- ----- ----- ----- ----- -----	49 mg/m3 350 mg/m3 147 mg/m3 172 mg/m3 172 mg/m3 217 mg/m3	4.9 mg/m3 35 mg/m3 15 mg/m3 17 mg/m3 17 mg/m3 22 mg/m3

Human data: An exposure of 4.7 mg/m³ per day resulted in fever, a basal metabolic rate of 400, rapid pulse and respiration, profuse sweating, shortness of breath, and cough [Fairhall 1957]. A single oral dose 75 mg produced no toxic effects in five volunteers [Harvey et al. 1951]. [Note: An oral dose of 75 mg is equivalent to a worker being exposed to 50 mg/m³ for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Revised IDLH: 5 mg/m3 [Unchanged] Basis for revised IDLH: Based on acute toxicity data in humans [Fairhall 1957; Harvey et al. 1951] and animals [Colliot 1972], the original IDLH for dinitro-o-cresol (5 mg/m3) is not being revised at this time.

REFERENCES:

1. Burkatskaya EN [1965]. Maximum permissible concentration of dinitro-o-cresol in air. Gig Tr Prof Zabol 30:34-37 (in Russian).

2. Colliot F [1972]. Intérêt présenté par l'acétate de dinoterbe pour le traitement d'hiver des arbres fruitiers et de la vigne. Defensi des Vegetaux 26:69-84 (in French).

3. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett 9(4):137-143.

4. Fairhall LT [1957]. Industrial toxicology. 2nd ed. Baltimore, MD: Williams & Wilkins Company, p. 230.

5. Harvey DG, Bidstrup PL, Bonnell JAL [1951]. Poisoning by dinitro-ortho-cresol. Some observations on the effects of dinitro-ortho-cresol administered by mouth to human volunteers. Br J Med 2:13-15.

6. Hunter D [1969]. Dinitro-ortho-cresol. In: The diseases of occupations. 4th ed. Boston, MA: Little, Brown and Company, pp. 559-567.

7. MacEwen JD, Vernot EH [1972]. Toxic Hazards Research Unit annual report: 1972. Wright-Patterson Air Force Base, OH: Air Force Systems Command, Aerospace Medical Division, Aerospace Medical Research Laboratory Report, AMRL-TR-72-62.

8. McDonald JM [1943]. Industrial hygiene in wartime Baltimore. Baltimore Health News 20(9):169-170.

9. Popov TA, Vrochinsky KK [1976]. Materials on substantiation of the threshold of DNOC in water bodies. Gig Sanit 41(6):12-15 (in Russian).

10. Spencer HC, Rowe VK, Adams EM, Irish DD [1948]. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol 30:10-28.