n-Butyl glycidyl ether

CAS number: 2426–08–6

NIOSH REL: 5.6 ppm (30 mg/m³) 15-minute CEILING

Current OSHA PEL: 50 ppm (270 mg/m³) TWA

1989 OSHA PEL: 25 ppm (135 mg/m³) TWA

1993-1994 ACGIH TLV: 25 ppm (133 mg/m³) TWA

Description of Substance: Colorless liquid with an irritating odor.

LEL: . . Unknown

Original (SCP) IDLH: 3,500 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that the mouse 4-hour LC₅₀ was greater than 3,500 ppm [Hine et al. 1956].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Mouse Rat	Hine et al. 1956 Hine et al. 1956	>3,500 1,030	----- -----	4 hr 8 hr	>7,000 ppm (2.0) 2,575 ppm (2.5)	>700 ppm 258 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Mouse Rat	Hine et al. 1956 Smyth et al. 1962	oral oral	1,530 2,050	----- -----	1,980 ppm 2,652 ppm	198 ppm 265 ppm

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 250 ppm Basis for revised IDLH: The revised IDLH for n-butyl glycidyl ether is 250 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCES:

1. ACGIH [1971]. n-Butyl glycidyl ether (BGE). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 33.

2. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.