sec-Hexyl acetate

CAS number: 108–84–9

NIOSH REL: 50 ppm (300 mg/m³) TWA

Current OSHA PEL: 50 ppm (300 mg/m³) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 50 ppm (295 mg/m³) TWA

Description of Substance: Colorless liquid with a mild, pleasant, fruity odor.

LEL:. . Unknown

Original (SCP) IDLH: 4,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that 2 of 6 rats died from a 4-hour exposure to 4,000 ppm [Smyth et al. 1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rat Rat	Smyth et al. 1954 UCC 1966	LC33: 4,000 -----	----- 2,000	4 hr 4 hr	8,000 ppm (2.0) 4,000 ppm (2.0)	800 ppm 400 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rat	UCC 1966	oral	6,160	-----	7,187 ppm	719 ppm

Human data: Volunteers noted an unpleasant odor and irritation of the eyes and upper respiratory tract at 100 ppm [Silverman et al. 1946].

Revised IDLH: 500 ppm Basis for revised IDLH: The revised IDLH for sec-hexyl acetate is 500 ppm based on acute inhalation toxicity data in humans [Silverman et al. 1946] and animals [Smyth et al. 1954; UCC 1966].

REFERENCES:

1. ACGIH [1971]. sec-Hexyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 127.

2. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

4. UCC [1966]. Toxicology studies: methyl amyl acetate. New York, NY: Union Carbide Corporation, Industrial Medicine and Toxicology Department (7/28/66).