Diisobutyl ketone

CAS number: 108–83–8

NIOSH REL: 25 ppm (150 mg/m³) TWA

Current OSHA PEL: 50 ppm (290 mg/m³) TWA

1989 OSHA PEL: 25 ppm (150 mg/m³) TWA

1993-1994 ACGIH TLV: 25 ppm (145 mg/m³) TWA

Description of Substance: Colorless liquid with a mild, sweet odor.

LEL(@200 F): 0.8% (10% LEL(@200 F), 800 ppm)

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that "breathing saturated vapors in air killed 1 of 6 animals in 8 hours; breathing 2,000 ppm for 8 hours killed 5 of 6 animals. Breathing 1,000 ppm for 8 hours produced illness but no deaths." This is the only useful data available on which to base the IDLH for this substance.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rat Rat	Smyth et al. 1949 Smyth et al. 1949	----- 2,000	2,000 -----	4 hr 8 hr	4,000 ppm (2.0) 5,000 ppm (2.5)	400 ppm 500 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rat Mouse Rat	NPIRI 1974 Shell 1961 Smyth et al. 1949	oral oral oral	5,750 1,416 5,800	----- ----- -----	6,799 ppm 1,674 ppm 6,858 ppm	680 ppm 167 ppm 686 ppm

Human data: It has been reported that a 3-hour exposure at 50 or 100 ppm caused slight irritation to the eyes, nose, and throat [Smyth et al. 1949].

Revised IDLH: 500 ppm Basis for revised IDLH: The revised IDLH for diisobutyl ketone is 500 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].

REFERENCES:

1. Carpenter CP, Pozzani UC, Weil CS [1953]. Toxicity and hazard of diisobutyl ketone vapors. AMA Arch Ind Hyg Occup Med 8:377-381.

2. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 23.

3. Shell [1961]. Unpublished report. Shell Chemical Company, p. 4.

4. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range-finding toxicity data: list III. J Ind Hyg Toxicol 31:60-62.

5. UCC [1971]. Toxicology studies: diisobutyl ketone. New York, NY: Union Carbide Corporation.