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Supplemental Analyses of Recent Trends in Infant Mortality

by Kenneth D. Kochanek, M.A., and Joyce A. Martin, M.P.H.

Overview

Preliminary data for 2002 indicate an increase in the infant mortality rate (IMR) to 7.0 deaths per 1,000 live births from 6.8 in 2001 (1) (Table 1). To better understand the increase in the IMR for 2002, the Centers for Disease Control and Prevention?s National Center for Health Statistics (NCHS) reviewed additional partially edited mortality records processed after the close of the preliminary data file as well as partially edited fetal death data for 2002 (processed as of January 2004). These data indicate that the increase in the 2002 IMR observed for preliminary data will be confirmed by final data, and that while the IMR increased, the perinatal mortality rate (late fetal deaths plus early neonatal deaths per 1,000 live births plus fetal deaths) remained stable. (Final statistics will be available later this year.)

The rise in the IMR is concentrated in the neonatal period (0-27 days), particularly in the early neonatal period (0-6 days) (Tables 1 and 2). The rate of late fetal mortality (fetal deaths of 28 or more weeks of gestation per 1,000 live births plus fetal deaths) shows a 3 percent decline for 2002 (slightly greater than the average annual decline for 1990-2001). As a result, the perinatal mortality rate, which more fully describes the risk of death at late stages of pregnancy and shortly after birth, appears unchanged for 2002 (Table 2 and Figure 1). The perinatal mortality rate had declined fairly consistently for more than half of a century.

Cause of Death

One way to better understand the increase in the IMR is to examine changes by cause using final 2001 and preliminary 2002 data. When examined by cause of infant death, 3 causes among the 10 leading causes of infant death appear to account for most of the current year increase: Congenital malformations, deformations and chromosomal abnormalities; Disorders related to short gestation and low birth weight, not elsewhere classified; and Newborn affected by maternal complications of pregnancy (Table 3). Historically, the majority of these deaths have been among infants born low birthweight (weight at delivery of less than 2,500 grams or 5 and one-half pounds). Despite steady increases in preterm and low birthweight rates between 1990 and 2002, trends over this time period for these three causes do not indicate a consistent pattern of increase or decrease (2-14). However, the interpretation of the cause of death trends is complicated by the change in the ICD revision in 1999 that created breaks in the comparability of cause of death statistics (5).

Historical Trends in Infant Mortality

The death registration area was completed in 1933 when all States were included in the collection of death statistics (15). Since then, with the exception of 1957-58, when a significant increase in the IMR was observed, the historical trend of the IMR has been one of steady, sometimes rapid decline. Through the 1930s and 1940s, the IMR declined by an average of 4 percent per year. The rate of decline slowed markedly to 1 percent per year for 1950 to 1964. Thereafter, until the early 1980s, infant mortality declined rapidly, by an average of almost 5 percent per year (16). From 1981 to 1989 the rate of decline again slowed to an average of 2 percent per year (3).

Recent Trends in Fetal and Infant Mortality

Over the more recent period, 1990 to 2001, the IMR declined 26 percent (from 9.2 to 6.8 per 1,000) for an average decrease of 3 percent per year (3) (Table 1 and Figure 2). Between 1990 and 2001 the neonatal mortality rate declined from 5.8 to 4.5 per 1,000 (down 22 percent) and the postneonatal mortality rate from 3.4 to 2.3 (down 32 percent) (3). Between 1990 and 2001, the late fetal mortality rate declined fairly steadily, by 23 percent, from 4.3 to 3.3 per 1,000 (17) (Table 2 ). The perinatal mortality rate also declined steadily between 1990 and 2001, from 9.1 to 6.9 for a total of 24 percent (Table 2 and Figure 2). Although the pace of decline has slowed somewhat since the mid-1990s, significant declines in late fetal mortality and infant mortality have been observed through 2001 despite substantial increases in preterm and low birthweight risk, two important predictors of perinatal health.

As discussed above, preliminary data for 2002 indicate a 3 percent rise in the IMR from 2001. The increase was observed for neonatal deaths only; a 4-percent increase in the neonatal mortality rate was reported, whereas the postneonatal rate remained constant. The increase in neonatal mortality was accompanied by a 3-percent decline in the late fetal mortality rate and, as a result, the perinatal mortality rate was unchanged for 2002.

In addition to releasing preliminary and final mortality and natality statistics, NCHS also releases monthly provisional counts of vital events (as differentiated from records of vital events) and corresponding rates along with cumulative provisional information for the past 12 months and for all months to date in the calendar year. The provisional series is subject to reporting inconsistencies with considerable variation in the resulting estimates (18). However, the provisional series can be used to get early information on more recent trends with the understanding that the findings may change when more complete data are available. NCHS currently has provisional counts of infant deaths for the first 9 months of 2003. These counts suggest an improvement in the IMR between 2002 and 2003; however, the provisional data are not stable enough to determine if the magnitude of that improvement is large enough to bring the rate down to or below the historically low level reached in 2001.

Potential Explanatory Factors for the Changes in the Infant Mortality Rate

Changes in the characteristics of births and changes in birthweight and gestation-specific infant mortality rates (i.e., the death rate for infants at a given weight or gestational age) may be related to changes in the IMR. Final birth data for 2002 indicate that the two key predictors of infant health, the percent of births born preterm (less than 37 completed weeks of gestation) and low birthweight (LBW), continued to climb, rising 1 to 2 percent for 2002 (2) (Table 2 and Figure 2). Increases in preterm and LBW rates of 3 and 1 percent respectively, were also noted between 2000 and 2001. Since 1990 preterm and LBW rates have risen fairly steadily, preterm by 14 percent (from 10.6 to 12.1 percent) and LBW by 11 percent (from 7.0 to 7.8 percent).

The bulk of the increase has been among moderately preterm (32-36 weeks of gestation) and moderately low birthweight (1,500-2,499 grams) infants. Between 1990 and 2002, the moderately preterm rate rose from 8.7 to 10.1 percent and the moderately low birthweight (MLBW) rate from 5.7 to 6.4 percent, whereas the very preterm rate (less than 32 weeks of gestation) rose from 1.92 to 1.96 percent and the very low birthweight rate (VLBW) (less than 1,500 grams) from 1.27 to 1.46 percent. Although still at increased risk compared with term or normal birthweight infants, infants born moderately preterm and MLBW, are at substantially lower risk than their very preterm and VLBW counterparts for early death. For 2001, 18 percent of infants born very preterm did not survive the first year of life compared with less than 1 percent of infants born moderately preterm (19).

Multiple births, more than half of which are born preterm and/or low birthweight, have contributed importantly to recent increases in preterm and LBW rates. Between 1990 and 2002 the multiple birth rate climbed 42 percent (a 3-percent rise was reported between 2001 and 2002) (2, 20); in 2002 nearly one-fourth of all LBW infants were born in a multiple delivery (2). Multiple births do not account for all of the preterm/LBW rise; however, the preterm rate for singletons alone increased 7 percent over this period (2). (While the rate of moderately preterm singleton births rose from 8.01 to 8.87 percent between 1990 and 2002, the very preterm rate for singletons declined slightly, from 1.69 to 1.57 percent.)

The increased use of assisted reproductive therapies (ART) such as in-vitro fertilization has been strongly associated with the growth in multiple gestation pregnancies (21) and may also be associated with an increased risk of LBW among singletons (22,23). One percent of all 2001 births were the result of ART procedures (24).

Changes in the management of labor and delivery influenced at least in part by the increased use of medical technologies (e.g., ultrasound) (25), and more aggressive management of premature rupture of the membranes (PROM) (26,27) may also be related to the trends in preterm/LBW births as induction of labor and cesarean delivery occur more often at earlier gestational ages; the use of induction of labor and of cesarean delivery among births delivered preterm has risen substantially in recent years (28-30).

Recent declines in infant mortality have been attributed to improvement in birthweight and gestation-specific infant mortality rates, not to the prevention of preterm or LBW births (31). The decline in birthweight and gestation-specific mortality has been attributed primarily to improvements in obstetric and neonatal care such as pulmonary surfactants for preterm infants. Data from the 2002 linked birth and infant death file, to be available in the summer of 2004, will allow us to assess whether changes in birthweight and gestation-specific mortality rates have contributed to the current year rise in the IMR.

Summary

Preliminary data for 2002 show a significant increase in the IMR to 7.0 infant deaths per 1,000 live births, the first rise in the U.S. IMR since 1958 (1,15). Review of additional partially edited 2002 mortality data indicate that the increase in the IMR will be confirmed by final data. The 2002 increase in infant mortality was concentrated in the neonatal period, particularly in deaths occurring within 7 days of birth. Partially edited fetal death data suggest that the increase in neonatal mortality was accompanied by a decline in the late fetal mortality rate for 2002, and thus it appears that the 2002 perinatal mortality rate will remain level.

Data from the 2002 linked birth and infant death file, which are expected to be available by the summer of 2004, will allow us to assess the contribution of maternal and infant factors such as multiple births and management of labor and delivery. With this file, it will also be possible to investigate whether changes in birthweight and gestation-specific neonatal mortality rates relate to the increase in infant mortality.

References

  1. Kochanek KD, Smith BL. Deaths: Preliminary data for 2002 [PDF – 2.3 MB]. National vital statistics reports; vol 52 no 13. Hyattsville, Maryland: National Center for Health Statistics. 2004.
  2. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, et al. Births: Final data for 2002. National vital statistics reports; vol 52 no 10. Hyattsville, Maryland: National Center for Health Statistics. 2003.
  3. Arias E, Anderson RN, Kung HC, Murphy SL, Kochanek KD. Deaths: Final data for 2001. National vital statistics reports; vol 52 no 3. Hyattsville, Maryland: National Center for Health Statistics. 2003.
  4. Minino AM, Arias E, Kochanek KD, Murphy SL, Smith BL. Deaths: Final data for 2000. National vital statistics reports; vol 50 no 15. Hyattsville, Maryland: National Center for Health Statistics. 2002.
  5. Hoyert DL, Arias E, Smith BL, Murphy SL, Kochanek KD. Deaths: Final data for 1999. National vital statistics reports; vol 49 no 8. Hyattsville, Maryland: National Center for Health Statistics. 2001.
  6. Murphy SL. Deaths: Final data for 1998. National vital statistics reports; vol 48 no 11. Hyattsville, Maryland: National Center for Health Statistics. 2000.
  7. Hoyert DL, Kochanek KD, Murphy SL. Deaths: Final data for 1997. National vital statistics reports; vol 47 no 19. Hyattsville, Maryland: National Center for Health Statistics. 1999.
  8. Peters KD, Kochanek KD, Murphy SL. Deaths: Final data for 1996. National vital statistics reports; vol 47 no 9. Hyattsville , Maryland : National Center for Health Statistics. 1998.
  9. Anderson RN, Kochanek KD, Murphy SL. Report of final mortality statistics, 1995. Monthly vital statistics report; vol 45 no 11, supp 2. Hyattsville , Maryland : National Center for Health Statistics. 1997.
  10. Singh GK, Kochanek KD, MacDorman MF. Advance report of final mortality statistics, 1994. Monthly vital statistics report; vol 45 no 3, supp. Hyattsville , Maryland : Public Health Service. 1996.
  11. Gardner P, Hudson BL. Advance report of final mortality statistics, 1993. Monthly vital statistics report; vol 44 no 7, supp. Hyattsville , Maryland : National Center for Health Statistics. 1996.
  12. Kochanek KD, Hudson BL. Advance report of final mortality statistics, 1992. Monthly vital statistics report; vol 43 no 6, supp. Hyattsville , Maryland : National Center for Health Statistics. 1995.
  13. National Center for Health Statistics. Advance report of final mortality statistics, 1991. Monthly vital statistics report; vol 42 no 2, supp. Hyattsville , Maryland : Public Health Service. 1993.
  14. National Center for Health Statistics. Advance report of final mortality statistics, 1990. Monthly vital statistics report; vol 41 no 7, supp. Hyattsville , Maryland : Public Health Service. 1993.
  15. National Center for Health Statistics. Vital statistics of the United States, 1993, vol II, mortality, part A. Hyattsville, Maryland. 2002.
  16. MacDorman MF, Rosenberg HM. Trends in infant mortality by cause of death and other characteristics, 1960-88. National Center for Health Statistics. Vital Health Stat 20(20). 1993.
  17. Fried VM, Prager K, MacKay AP, Xia H. Chartbook on Trends in the Health of Americans. Health , United States , 2003. Hyattsville , Maryland : National Center for Health Statistics. 2003.
  18. Sutton PD, Munson ML. Births, marriages, divorces, and deaths: Provisional data for September 2003. National vital statistics reports; vol 52 no 16. Hyattsville , Maryland : National Center for Health Statistics. 2004. (Forthcoming)
  19. Mathews TJ, Menacker F, MacDorman MF. Infant mortality statistics from the 2001 period linked birth/infant death data set. National vital statistics reports; vol 52 no 2. Hyattsville , Maryland : National Center for Health Statistics. 2003.
  20. Martin JA, Park MM. Trends in twin and triplet births: 1980-97. National vital statistics reports; vol 47 no 24. Hyattsville , Maryland : National Center for Health Statistics. 1999.
  21. Centers for Disease Control and Prevention. Contribution of assisted reproductive technology and ovulation-inducing drugs to triplet and higher-order multiple births?United States, 1980-1997. MMWR 49(24):535-8. 2000.
  22. Schieve LA, Meikle SF, Ferre C, et al. Low and very low birth weight in infants conceived with use of assisted reproductive technology. NEJM 346(10):731-7. 2002.
  23. Helmerhorst FM, Perquin DAM, Donker D, et al. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 10.1136/bmj.37957.56278.EE. 2004.
  24. Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology, RESOLVE 2001. Assisted reproductive technology success rates: national summary and fertility clinic report, Atlanta: Centers for Disease Contol and Prevention, 2001.
  25. Reuwer PJH, Sijmans EA, Rietman GW. Intrauterine growth retardation: Prediction of perinatal distress by Doppler ultrasound. Lancet, August 22: 415-8. 1987.
  26. Naef RW III, Allbert JR, Ross EL, et al. Premature rupture of membranes at 34 to 37 weeks? gestation: Aggressive versus conservative management. Am J Obstet Gynecol 178(1):126-9. 1998.
  27. Grable IA. Cost-effectiveness of induction after preterm premature rupture of the membranes. Am J Obstet Gynecol 187(5):1153-8. 2002.
  28. MacDorman MF, Mathews TJ, Martin JA, Malloy MH. Trends and characteristics of induced labour in the United States, 1989-98. Paediatr and Perinat Epidemiol 16: 263-73. 2002.
  29. Zhang J, Yancey MK, Henderson CE. U.S. national trends in labor induction, 1989-98. J Reprod Med 47(2): 120-4. 2002.
  30. Redman ME, Gonik B. Cesarean delivery rates at the threshold of viability. Am J Obstet Gynecol 187(4):873-6. 2002.
  31. Allen MC, Alexander GR, Tompkins ME, Hulsey TC. Racial differences in temporal changes in newborn viability and survival by gestational age. Paediatr Perinat Epidemiol 14:152-8. 2000.

Definition of terms

Infant mortality rate – Deaths of infants aged under 1 year per 1,000 or 100,000 live births. The infant mortality rate is the sum of the neonatal and postneonatal mortality rates.

Neonatal mortality rate – Deaths of infants aged 0-27 days per 1,000 live births. The neonatal mortality rate is the sum of the early neonatal and late neonatal mortality rates.

Early neonatal mortality rate – Deaths of infants aged 0-6 days per 1,000 live births.

Late neonatal mortality rate – Deaths of infants aged 7-27 days per 1,000 live births.

Postneonatal mortality rate – Deaths to infants aged 28 days-1 year per 1,000 live births.

Late fetal mortality rate – Fetal deaths of 28 or more weeks of gestation per 1,000 live births plus fetal deaths.

Perinatal mortality rate – Late fetal deaths plus early neonatal deaths per 1,000 live births plus fetal deaths.

Low birthweight rate – Births with weight at delivery of less than 2,500 grams per 100 live births. The low birthweight rate is the sum of the moderately low and very low birthweight rates.

Moderately low birthweight rate – Births with weight at delivery of 1,500-2,499 grams per 100 live births.

Very low birthweight rate – Births with weight at delivery of less than 1,500 grams per 100 live births.

Term – Births at 37-41 weeks of gestation.

Preterm rate – Births at less than 37 completed weeks of gestation per 100 live births. The preterm rate is the sum of the moderately and very preterm rates.

Moderately preterm rate – Births at 32-36 weeks of gestation per 100 live births.

Very preterm rate – Births at less than 32 weeks of gestation per 100 live births.

Acknowledgments

The authors would like to acknowledge the assistance of Jennifer H. Madans, Office of the Director; Charles J. Rothwell, Director of the Division of Vital Statistics; James A. Weed, Acting Chief, Robert N. Anderson, Lead Statistician, and Betty L. Smith of the Mortality Statistics Branch; Stephanie J. Ventura, Chief, T. J. Mathews and Paul D. Sutton of the Reproductive Statistics Branch; Steven J. Steimel and Jaleh Mousavi of the Systems, Programming and Statistical Resources Branch; and David Justice of the Data Acquisition and Evaluation Branch.

Figures

Figure 1. Perinatal, late fetal, and early neonatal mortality rates, 1990-2002
Figure 1 is a line chart plotting perinatal, late fetal, and early neonatal mortality rates from 1990 to 2002. All lines show a steady downward trend

Figure 2. Rates of infant mortality, low birthweight, and preterm birth, 1990-2002
Figure 2 is a line chart plotting percent of perinatal mortality, early neonatal mortality, and late fetal mortality from 1990 to 2002. Preterm and low birthweight show an upward trend over time, whereas infant mortality shows a downward trend

Tables

Table 1. Infant deaths and infant, neonatal, and postneonatal mortality rates: United States, 1933, 1940, 1950, 1960, 1970, and 1975-2001 final, and 2002 (preliminary and latest processed)

[Rates per 1,000 live births]

Infant mortality rate
Neonatal (under 28 days)
Year Infant deaths Total Total Under 7 days 7-27 days Postneonatal (28 days – 11 months)
20021 28,042 7.0 4.7 3.7 0.9 2.3
20022 27,977 7.0 4.7 ? ? 2.3
2001 27,568 6.8 4.5 3.6 0.9 2.3
2000 28,035 6.9 4.6 3.7 1.0 2.3
1999 27,937 7.1 4.7 3.8 1.0 2.3
1998 28,371 7.2 4.8 3.8 1.0 2.4
1997 28,045 7.2 4.8 3.8 0.9 2.5
1996 28,487 7.3 4.8 3.8 0.9 2.5
1995 29,583 7.6 4.9 4.0 0.9 2.7
1994 31,710 8.0 5.1 4.2 0.9 2.9
1993 33,466 8.4 5.3 4.3 0.9 3.1
1992 34,628 8.5 5.4 4.4 1.0 3.1
1991 36,766 8.9 5.6 4.6 1.0 3.4
1990 38,351 9.2 5.8 4.8 1.0 3.4
1989 39,655 9.8 6.2 5.1 1.1 3.6
1988 38,910 10.0 6.3 5.2 1.1 3.6
1987 38,408 10.1 6.5 5.4 1.1 3.6
1986 38,891 10.4 6.7 5.6 1.1 3.6
1985 40,030 10.6 7.0 5.8 1.2 3.7
1984 39,580 10.8 7.0 5.9 1.1 3.8
1983 40,627 11.2 7.3 6.1 1.2 3.9
1982 42,401 11.5 7.7 6.4 1.3 3.8
1981 43,305 11.9 8.0 6.7 1.3 3.9
1980 45,526 12.6 8.5 7.1 1.4 4.1
1979 45,665 13.1 8.9 7.5 1.4 4.2
1978 45,945 13.8 9.5 8.0 1.5 4.3
1977 46,975 14.1 9.9 8.4 1.5 4.2
1976 48,265 15.2 10.9 9.3 1.6 4.3
1975 50,525 16.1 11.6 10.0 1.6 4.5
1970 74,667 20.0 15.1 13.6 1.5 4.9
1960 110,873 26.0 18.7 16.7 2.0 7.3
1950 103,825 29.2 20.5 17.8 2.7 8.7
1940 110,984 47.0 28.8 23.3 5.5 18.3
19333 120,887 58.1 34.0 26.3 7.7 24.1

? Data not available.

1 Partially edited data processed through January 2004.

2 Preliminary data processed though July 10, 2003.

3 First year in which all States were included in the collection of death statistics.

SOURCE: Various CDC/NCHS publications; see text.

Table 2a. Trends in measures of perinatal health: United States, 1990-2002

Preterm1
Percent
Year Number Total Very preterm1 Moderately perterm1
2002 480,812 12.1 2.0 10.1
2001 476,250 11.9 1.9 10.0
2000 467,201 11.6 1.9 9.7
1999 460,853 11.8 2.0 9.8
1998 452,275 11.6 2.0 9.6
1997 436,600 11.4 1.9 9.4
1996 423,107 11.0 1.9 9.1
1995 424,455 11.0 1.9 9.1
1994 431,613 11.0 1.9 9.1
1993 435,625 11.0 1.9 9.1
1992 430,239 10.7 1.9 8.8
1991 440,082 10.8 1.9 8.9
1990 436,590 10.6 1.9 8.7

See footnotes at end of Table 2c.

Table 2b. Trends in measures of perinatal health: United States, 1990-2002

Low birthweight2
Percent
Year Number Total Very low birthweigth2 Moderately low birthweight2
2002 314,077 7.8 1.5 6.4
2001 308,747 7.7 1.4 6.2
2000 307,030 7.6 1.4 6.1
1999 301,183 7.6 1.5 6.2
1998 298,208 7.6 1.4 6.1
1997 291,154 7.5 1.4 6.1
1996 287,230 7.4 1.4 6.0
1995 285,152 7.3 1.3 6.0
1994 287,607 7.3 1.3 6.0
1993 288,482 7.2 1.3 5.9
1992 287,493 7.1 1.3 5.8
1991 292,230 7.1 1.3 5.8
1990 289,418 7.0 1.3 5.7

See footnotes at end of Table 2c.

Table 2c. Trends in measures of perinatal health: United States, 1990-2002

Late fetal mortality3 Early neonatal mortality4 Perinatal mortality5
Year Number Rate Number Rate Number Rate
20026 12,871 3.2(3.19) 15,003 3.7 27,874 6.9
2001 13,251 3.3(3.28) 14,611 3.6 27,862 6.9
2000 13,506 3.3 14,913 3.7 28,419 7.0
1999 13,427 3.4 14,889 3.8 28,316 7.1
1998 13,474 3.4 15,073 3.8 28,547 7.2
1997 13,686 3.5 14,859 3.8 28,545 7.3
1996 14,078 3.6 14,968 3.8 29,046 7.4
1995 14,251 3.6 15,515 4.0 29,766 7.6
1994 14,781 3.7 16,523 4.2 31,304 7.9
1993 15,297 3.8 17,395 4.3 32,692 8.1
1992 16,782 4.1 17,798 4.4 34,580 8.5
1991 17,010 4.1 18,916 4.6 35,926 8.7
1990 17,959 4.3 20,020 4.8 37,979 9.1

1 Less than 37 completed weeks of gestation. Very preterm is less than 32 completed weeks of gestation. Moderately preterm is 32-36 completed weeks of gestation.

2 Less than 2,500 grams. Very low birthweight is less than 1,500 grams. Moderately low birthweight is 1,500-2,499 grams.

3 The late fetal mortality rate = fetal deaths with stated or presumed gestational ages of 28 weeks or more per 1,000 live births plus late fetal deaths.

4 Deaths to infants less than 7 days per 1,000 live births.

5 Late fetal deaths plus infant deaths less than 7 days per 1,000 live births plus late fetal deaths.

6 Partially edited data processed as of January 2004.

SOURCE: Various CDC/NCHS publications; see text.

Table 3a. Infant deaths and infant mortality rates for all causes and infant mortality rates by leading causes: United States, preliminary 2002, and final 1990-2001

[Rates per 100,000 live births]

ICD-101
Cause of death (Based on the International Classification of Diseases, Tenth Revision, 1992) 20024 2001 2000 1999
All causes (deaths) 27,977 27,568 28,035 27,937
All causes (rates) 696.1 684.8 690.7 705.6

See footnotes at end of Table 3d.

Table 3b. Infant deaths and infant mortality rates for all causes and infant mortality rates by leading causes: United States, preliminary 2002, and final 1990-2001

[Rates per 100,000 live births]

ICD-92,3
Cause of death (Based on the International Classification of Diseases, Tenth Revision, 1992) 1998 1997 1996 1995 1994 1993 1992 1991 1990
All causes (deaths) 28,371 28,045 28,487 29,583 31,710 33,466 34,628 36,766 38,351
All causes (rates) 719.8 722.6 732.0 758.6 802.2 836.6 851.9 894.4 922.3

See footnotes at end of Table 3d.

Table 3c. Infant deaths and infant mortality rates for all causes and infant mortality rates by leading causes: United States, preliminary 2002, and final 1990-2001

[Rates per 100,000 live births]

ICD-92,3
Cause of death (Based on the International Classification of Diseases, Tenth Revision, 1992) 1998 1997 1996 1995 1994 1993 1992 1991 1990
Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) 157.6 159.2 164.0 168.1 173.4 178.2 183.2 186.9 198.1
Disorders relating to short gestation and low
birth weight, not elsewhere classified (P07)
104.0 101.1 100.3 100.9 107.6 107.7 99.3 100.7 96.5
Sudden infant death syndrome (R95) 71.6 77.1 78.4 87.1 103.0 116.7 120.3 130.1 130.3
Newborn affected by maternal complications of
pregnancy (P01)
34.1 32.1 32.1 33.6 32.8 33.6 35.9 37.4 39.8
Newborn affected by complications of placenta,
cord and membranes (P02)
24.4 24.7 24.4 24.7 24.0 24.8 24.4 23.4 23.4
Respiratory distress of newborn (P22) 32.9 33.5 35.0 37.3 39.6 45.4 50.8 62.5 68.5
Accidents (unintentional injuries) (V01-X59) 18.3 19.0 20.0 19.5 21.7 21.6 19.2 22.3 21.8
Bacterial sepsis of newborn (P36) 18.7 18.4 17.6 18.4 18.7 17.2 19.8 19.3 19.2
Diseases of the circulatory system (I00-I99) 25.2 24.7 24.3 24.8 24.1 23.6 23.2 22.8 24.5
Intrauterine hypoxia and birth asphyxia (P20-P21) 11.7 11.6 11.0 12.2 13.6 13.7 15.1 14.6 18.3

See footnotes at end of Table 3d.

Table 3d. Infant deaths and infant mortality rates for all causes and infant mortality rates by leading causes: United States, preliminary 2002, and final 1990-2001

[Rates per 100,000 live births]

ICD-101
Cause of death (Based on the International Classification of Diseases, Tenth Revision, 1992) 20024 2001 2000 1999
Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) 140.7 136.9 141.5 138.2
Disorders relating to short gestation and low
birth weight, not elsewhere classified (P07)
114.4 109.5 108.3 110.9
Sudden infant death syndrome (R95) 50.6 55.5 62.2 66.9
Newborn affected by maternal complications of
pregnancy (P01)
42.9 37.2 34.6 35.3
Newborn affected by complications of placenta,
cord and membranes (P02)
25.3 25.3 26.2 25.9
Respiratory distress of newborn (P22) 23.8 25.1 24.6 28.0
Accidents (unintentional injuries) (V01-X59) 22.2 24.2 21.7 21.3
Bacterial sepsis of newborn (P36) 18.3 17.3 18.9 17.5
Diseases of the circulatory system (I00-I99) 16.1 15.4 16.3 16.8
Intrauterine hypoxia and birth asphyxia (P20-P21) 14.4 13.3 15.5 15.5

1 World Health Organization. International Statistical Classification of Diseases and Related Health Problems, Tenth Revision. Geneva: World Health Organization. 1992.

2 World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, based on the recommendations of the Ninth Revision Conference, 1975. Geneva: World Health Organization. 1977.

3 Cause of death titles in ICD-9 differ in some cases from those in ICD-10. Breaks in the comparability of some causes listed have resulted in changes in category titles and from coding rules used to select the underlying cause of death. Comparisons between 1998 and 1999 infant mortality rates by cause of death in this table should not be made. The trends displayed should be interpreted separately as trends from 1990-1998 and 1999-2002. For a complete explanation of differences and measurement of the discontinuities between ICD-9 and ICD-10, see reference number 5 from the text section of this Health E-Stat.

4 Preliminary data for 2002 processed through July 10, 2003.

SOURCE: Various CDC/NCHS publications; see text.

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