SERPINE1 Allele and Genotype Frequencies

Available polymorphism(s)

rs number	Common Designations Nucleotide change Amino acid		Genotyping method
rs1799762 rs1799768 rs1799889	4G/5G insertion/deletion in promoter		MGB Eclipse

By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs1799762§		4G	5G		4G/4G	4G/5G	5G/5G
	Non-Hispanic White	52.5 (50.8, 54.3)	47.5 (45.7, 49.2)	<0.001	27.7 (25.8, 29.6)	49.7 (47.8, 51.7)	22.6 (20.6, 24.7)	<0.001	0.92
	Non-Hispanic Black	26.7 (25.0, 28.4)	73.3 (71.6, 75.0)		6.6 (5.3, 8.3)	40.1 (37.8, 42.5)	53.3 (50.8, 55.7)		0.17
	Mexican American	34.0 (31.5, 36.6)	66.0 (63.4, 68.5)		11.9 (9.5, 14.9)	44.2 (41.9, 46.5)	43.9 (41.0, 46.9)		0.46
	Total*	47.9 (46.0, 49.8)	52.1 (50.2, 54.0)		24.0 (22.4, 25.6)	47.8 (46.1, 49.6)	28.2 (25.8, 30.7)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
§ Variant also known as rs1799768 and rs1799889.

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By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1799762†		4G	5G		4G/4G	4G/5G	5G/5G
	12-19	45.4 (41.3, 49.5)	54.6 (50.5, 58.7)	0.024	21.2 (17.3, 25.7)	48.4 (44.4, 52.3)	30.4 (25.8, 35.5)	0.013
	20-39	46.6 (44.3, 48.9)	53.4 (51.1, 55.7)		22.4 (20.2, 24.8)	48.4 (44.8, 52.0)	29.2 (25.9, 32.7)
	40-59	49.9 (47.2, 52.6)	50.1 (47.4, 52.8)		26.7 (23.8, 29.7)	46.5 (43.8, 49.3)	26.8 (23.8, 30.0)
	>=60	49.3 (47.6, 51.0)	50.7 (49.0, 52.4)		25.3 (22.4, 28.3)	48.1 (44.1, 52.1)	26.6 (24.4, 29.0)
	Total	47.9 (46.0, 49.8)	52.1 (50.2, 54.0)		24.0 (22.4, 25.6)	47.8 (46.1, 49.6)	28.2 (25.8, 30.7)

* Includes all participants, regardless of race/ethnicity.
† Variant also known as rs1799768 and rs1799889.
 

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By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1799762†		4G	5G		4G/4G	4G/5G	5G/5G
	Male	48.0 (45.3, 50.8)	52.0 (49.2, 54.7)	0.833	25.3 (22.6, 28.2)	45.4 (42.2, 48.7)	29.2 (25.8, 32.9)	0.050
	Female	47.7 (45.8, 49.7)	52.3 (50.3, 54.2)		22.7 (20.8, 24.8)	50.1 (48.4, 51.7)	27.2 (25.1, 29.5)
	Total	47.9 (46.0, 49.8)	52.1 (50.2, 54.0)		24.0 (22.4, 25.6)	47.8 (46.1, 49.6)	28.2 (25.8, 30.7)

* Includes all participants, regardless of race/ethnicity.
† Variant also known as rs1799768 and rs1799889.

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By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs1799762*			4G	5G	4G/4G	4G/5G	5G/5G
	Non-Hispanic White	12-19	50.0 (45.7, 54.2)	50.0 (45.8, 54.3)	24.8 (19.9, 30.5)	50.4 (44.1, 56.6)	24.8 (20.0, 30.4)
		20-39	52.7 (49.8, 55.6)	47.3 (44.4, 50.2)	27.0 (23.7, 30.5)	51.5 (47.4, 55.6)	21.5 (18.0, 25.5)
		40-59	53.7 (50.7, 56.6)	46.3 (43.4, 49.3)	29.7 (26.6, 33.0)	48.0 (44.9, 51.0)	22.3 (19.1, 25.9)
		>=60	52.1 (49.9, 54.3)	47.9 (45.7, 50.1)	27.7 (24.7, 30.9)	48.7 (45.1, 52.4)	23.5 (21.1, 26.2)
	Non-Hispanic Black	12-19	25.8 (23.1, 28.8)	74.2 (71.2, 76.9)	5.6 (3.5, 9.1)	40.3 (37.7, 43.0)	54.0 (50.5, 57.5)
		20-39	26.8 (23.5, 30.3)	73.2 (69.7, 76.5)	7.2 (4.7, 10.8)	39.1 (36.1, 42.2)	53.7 (49.3, 58.0)
		40-59	27.6 (24.5, 31.0)	72.4 (69.0, 75.5)	7.1 (4.8, 10.4)	41.1 (35.1, 47.3)	51.8 (46.1, 57.6)
		>=60	25.7 (22.5, 29.3)	74.3 (70.7, 77.5)	5.1 (2.5, 10.2)	41.2 (34.3, 48.5)	53.7 (47.7, 59.6)
	Mexican American	12-19	36.7 (30.3, 43.6)	63.3 (56.4, 69.7)	14.0 (9.3, 20.6)	45.3 (40.2, 50.6)	40.6 (32.5, 49.3)
		20-39	31.6 (29.1, 34.2)	68.4 (65.8, 70.9)	10.0 (7.8, 12.8)	43.1 (38.3, 48.2)	46.8 (42.4, 51.3)
		40-59	36.0 (30.4, 41.9)	64.0 (58.1, 69.6)	13.3 (7.5, 22.4)	45.4 (38.4, 52.6)	41.3 (35.4, 47.6)
		>=60	36.9 (33.2, 40.7)	63.1 (59.3, 66.8)	14.4 (11.0, 18.7)	44.9 (41.0, 48.8)	40.7 (36.1, 45.4)

* Variant also known as rs1799768 and rs1799889.

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By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs1799762*			4G	5G	4G/4G	4G/5G	5G/5G
	Non-Hispanic White	Male	52.5 (49.5, 55.5)	47.5 (44.5, 50.5)	28.8 (25.3, 32.6)	47.5 (43.7, 51.2)	23.7 (20.5, 27.3)
		Female	52.5 (50.8, 54.3)	47.5 (45.7, 49.2)	26.6 (24.2, 29.1)	51.9 (49.3, 54.5)	21.5 (19.7, 23.4)
	Non-Hispanic Black	Male	27.2 (25.3, 29.1)	72.8 (70.9, 74.7)	6.1 (4.4, 8.5)	42.0 (38.3, 45.9)	51.8 (48.6, 55.1)
		Female	26.3 (24.2, 28.5)	73.7 (71.5, 75.8)	7.0 (5.7, 8.6)	38.5 (35.6, 41.6)	54.5 (51.0, 57.9)
	Mexican American	Male	33.2 (30.5, 36.1)	66.8 (63.9, 69.5)	12.0 (9.2, 15.4)	42.5 (38.8, 46.2)	45.5 (42.0, 49.1)
		Female	34.8 (31.8, 38.0)	65.2 (62.0, 68.2)	11.8 (9.4, 14.7)	46.0 (43.3, 48.8)	42.2 (38.2, 46.3)

* Variant also known as rs1799768 and rs1799889

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