NAT2 Allele and Genotype Frequencies
ShareCompartir
This website is archived for historical purposes and is no longer being maintained or updated.
Available polymorphism(s)
|
rs number |
Common Designations
Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs1041983 |
Ex2+288C>T |
Tyr94Tyr |
TaqMan |
|
rs1208 |
Ex2-367A>G |
Lys268Arg |
TaqMan |
|
rs1799930 |
Ex2-580G>A |
Arg197Gln |
TaqMan |
|
rs1801279 |
Ex2+197G>A |
Arg64Gln |
TaqMan |
|
rs1801280 |
Ex2+347T>C |
Ile114Thr |
TaqMan |
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs1041983 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 64.6 (62.9, 66.2) | 35.4 (33.8, 37.1) | <0.001 | 41.4 (38.9, 43.9) | 46.3 (43.8, 48.9) | 12.3 (10.8, 13.8) | <0.001 | 0.77 | |
| Non-Hispanic Black | 53.9 (52.4, 55.4) | 46.1 (44.6, 47.6) | 30.8 (28.9, 32.8) | 46.2 (43.8, 48.5) | 23.0 (21.2, 24.9) | 0.03 | |||
| Mexican American | 68.1 (65.6, 70.6) | 31.9 (29.4, 34.4) | 46.7 (43.4, 50.1) | 42.8 (40.1, 45.6) | 10.5 (8.4, 12.9) | 0.66 | |||
| Total* | 63.6 (62.1, 65.0) | 36.4 (35.0, 37.9) | 40.4 (38.4, 42.4) | 46.3 (44.6, 48.1) | 13.3 (12.0, 14.7) | ||||
| rs1208 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 59.0 (57.7, 60.1) | 41.0 (39.9, 42.3) | <0.001 | 34.5 (33.1, 36.0) | 48.9 (47.3, 50.4) | 16.6 (15.2, 18.1) | <0.001 | 0.67 | |
| Non-Hispanic Black | 61.7 (60.3, 63.1) | 38.3 (36.9, 39.7) | 39.3 (37.3, 41.2) | 44.9 (42.7, 47.2) | 15.8 (14.2, 17.5) | 0.06 | |||
| Mexican American | 64.3 (62.1, 66.5) | 35.7 (33.5, 37.9) | 41.2 (38.2, 44.4) | 46.2 (43.5, 48.9) | 12.6 (10.8, 14.6) | 0.68 | |||
| Total* | 60.6 (59.8, 61.5) | 39.4 (38.5, 40.2) | 37.2 (35.9, 38.5) | 46.8 (45.4, 48.2) | 15.9 (15.1, 16.8) | ||||
| rs1799930 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 32.3 (30.5, 34.1) | 67.7 (65.9, 69.5) | <0.001 | 10.1 (8.7, 11.7) | 44.4 (42.0, 46.7) | 45.5 (42.8, 48.2) | <0.001 | 0.83 | |
| Non-Hispanic Black | 28.0 (25.8, 30.3) | 72.0 (69.7, 74.2) | 8.7 (7.1, 10.5) | 38.6 (35.6, 41.8) | 52.7 (49.2, 56.2) | 0.04 | |||
| Mexican American | 18.0 (16.0, 20.1) | 82.0 (79.9, 84.0) | 3.2 (2.2, 4.7) | 29.5 (26.0, 33.2) | 67.3 (63.5, 70.9) | 0.70 | |||
| Total* | 30.2 (28.9, 31.5) | 69.8 (68.5, 71.1) | 8.9 (7.9, 10.1) | 42.6 (40.8, 44.5) | 48.5 (46.5, 50.5) | ||||
| rs1801279 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 0.0 (0.0, 0.1) | 100.0 (99.9, 100.0) | <0.001 | 0.0 (NA) | 0.1 (0.0, 0.3) | 99.9 (99.7, 100.0) | <0.001 | 0.97 | |
| Non-Hispanic Black | 7.8 (6.9, 8.8) | 92.2 (91.2, 93.1) | 0.4 (0.2, 0.9) | 14.9 (13.1, 16.8) | 84.7 (82.8, 86.5) | 0.05 | |||
| Mexican American | 0.5 (0.3, 0.9) | 99.5 (99.1, 99.7) | 0.0 (0.0, 0.1) | 1.0 (0.6, 1.8) | 99.0 (98.2, 99.4) | <0.01 | |||
| Total* | 1.0 (0.8, 1.3) | 99.0 (98.7, 99.2) | 0.0 (0.0, 0.1) | 2.0 (1.5, 2.6) | 98.0 (97.4, 98.4) | ||||
| rs1801280 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 42.1 (40.9, 43.3) | 57.9 (56.7, 59.1) | <0.001 | 17.5 (15.9, 19.2) | 49.3 (47.4, 51.3) | 33.2 (31.8, 34.7) | <0.001 | 0.85 | |
| Non-Hispanic Black | 29.3 (27.7, 30.9) | 70.7 (69.1, 72.3) | 9.1 (7.8, 10.7) | 40.3 (37.5, 43.1) | 50.6 (48.0, 53.3) | 0.65 | |||
| Mexican American | 32.4 (29.5, 35.3) | 67.6 (64.7, 70.5) | 10.1 (7.9, 12.9) | 44.4 (41.5, 47.4) | 45.4 (41.6, 49.3) | 0.60 | |||
| Total* | 38.9 (37.8, 40.0) | 61.1 (60.0, 62.2) | 15.7 (14.5, 16.8) | 46.5 (44.7, 48.2) | 37.9 (36.2, 39.6) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1041983 | C | T | CC | CT | TT | |||
| 12-19 | 62.6 (58.6, 66.5) | 37.4 (33.5, 41.4) | 0.841 | 38.6 (33.5, 43.8) | 48.2 (42.1, 54.4) | 13.3 (9.1, 18.9) | 0.909 | |
| 20-39 | 63.3 (61.0, 65.5) | 36.7 (34.5, 39.0) | 40.3 (37.4, 43.3) | 45.9 (43.3, 48.6) | 13.7 (11.7, 16.1) | |||
| 40-59 | 63.9 (61.1, 66.6) | 36.1 (33.4, 38.9) | 40.2 (35.9, 44.7) | 47.4 (42.4, 52.4) | 12.4 (9.8, 15.6) | |||
| >=60 | 64.3 (61.8, 66.7) | 35.7 (33.3, 38.2) | 42.2 (38.0, 46.5) | 44.2 (39.6, 48.8) | 13.6 (11.7, 15.8) | |||
| Total | 63.6 (62.1, 65.0) | 36.4 (35.0, 37.9) | 40.4 (38.4, 42.4) | 46.3 (44.6, 48.1) | 13.3 (12.0, 14.7) | |||
| rs1208 | A | G | AA | AG | GG | |||
| 12-19 | 61.2 (57.6, 64.8) | 38.8 (35.2, 42.4) | 0.876 | 38.2 (33.1, 43.6) | 46.1 (41.8, 50.5) | 15.7 (13.0, 18.8) | 0.989 | |
| 20-39 | 60.6 (58.5, 62.7) | 39.4 (37.3, 41.5) | 37.3 (33.6, 41.1) | 46.7 (42.4, 51.0) | 16.1 (14.3, 18.0) | |||
| 40-59 | 60.9 (59.1, 62.7) | 39.1 (37.3, 40.9) | 37.1 (34.1, 40.3) | 47.5 (42.9, 52.2) | 15.3 (12.7, 18.3) | |||
| >=60 | 59.9 (57.8, 62.0) | 40.1 (38.0, 42.2) | 36.6 (34.5, 38.7) | 46.6 (44.2, 49.1) | 16.8 (14.2, 19.7) | |||
| Total | 60.6 (59.8, 61.5) | 39.4 (38.5, 40.2) | 37.2 (35.9, 38.5) | 46.8 (45.4, 48.2) | 15.9 (15.1, 16.8) | |||
| rs1799930 | A | G | AA | AG | GG | |||
| 12-19 | 30.2 (26.7, 34.1) | 69.8 (65.9, 73.3) | 0.823 | 8.7 (6.1, 12.4) | 43.0 (38.0, 48.2) | 48.2 (42.7, 53.8) | 0.574 | |
| 20-39 | 29.6 (27.5, 31.9) | 70.4 (68.1, 72.5) | 8.9 (7.1, 11.1) | 41.5 (38.7, 44.3) | 49.6 (46.5, 52.8) | |||
| 40-59 | 30.5 (28.3, 32.8) | 69.5 (67.2, 71.7) | 8.1 (6.0, 11.0) | 44.7 (40.1, 49.4) | 47.1 (43.3, 50.9) | |||
| >=60 | 30.9 (29.2, 32.7) | 69.1 (67.3, 70.8) | 10.2 (8.6, 12.1) | 41.5 (37.4, 45.7) | 48.3 (45.0, 51.7) | |||
| Total | 30.2 (28.9, 31.5) | 69.8 (68.5, 71.1) | 8.9 (7.9, 10.1) | 42.6 (40.8, 44.5) | 48.5 (46.5, 50.5) | |||
| rs1801279 | A | G | AA | AG | GG | |||
| 12-19 | 1.3 (0.9, 1.9) | 98.7 (98.1, 99.1) | 0.147 | 0.1 (0.0, 0.7) | 2.4 (1.7, 3.3) | 97.5 (96.4, 98.3) | 0.197 | |
| 20-39 | 1.1 (0.8, 1.6) | 98.9 (98.4, 99.2) | 0.1 (0.0, 0.2) | 2.1 (1.4, 3.0) | 97.9 (97.0, 98.5) | |||
| 40-59 | 1.1 (0.8, 1.5) | 98.9 (98.5, 99.2) | 0.0 (0.0, 0.2) | 2.1 (1.5, 3.0) | 97.9 (97.0, 98.5) | |||
| >=60 | 0.7 (0.4, 1.1) | 99.3 (98.9, 99.6) | 0.0 (0.0, 0.1) | 1.3 (0.8, 2.1) | 98.7 (97.9, 99.1) | |||
| Total | 1.0 (0.8, 1.3) | 99.0 (98.7, 99.2) | 0.0 (0.0, 0.1) | 2.0 (1.5, 2.6) | 98.0 (97.4, 98.4) | |||
| rs1801280 | C | T | CC | CT | TT | |||
| 12-19 | 37.6 (34.3, 41.0) | 62.4 (59.0, 65.7) | 0.540 | 13.4 (10.5, 16.9) | 48.5 (43.4, 53.6) | 38.2 (33.3, 43.3) | 0.591 | |
| 20-39 | 38.7 (36.2, 41.2) | 61.3 (58.8, 63.8) | 15.7 (13.8, 17.7) | 46.0 (42.3, 49.8) | 38.3 (34.5, 42.3) | |||
| 40-59 | 38.7 (37.0, 40.5) | 61.3 (59.5, 63.0) | 15.3 (12.6, 18.5) | 46.8 (42.5, 51.1) | 37.9 (35.4, 40.5) | |||
| >=60 | 40.5 (37.9, 43.1) | 59.5 (56.9, 62.1) | 17.8 (14.8, 21.2) | 45.4 (42.2, 48.6) | 36.8 (34.0, 39.8) | |||
| Total | 38.9 (37.8, 40.0) | 61.1 (60.0, 62.2) | 15.7 (14.5, 16.8) | 46.5 (44.7, 48.2) | 37.9 (36.2, 39.6) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1041983 | C | T | CC | CT | TT | |||
| Male | 64.1 (62.1, 66.0) | 35.9 (34.0, 37.9) | 0.239 | 41.2 (38.8, 43.6) | 45.8 (43.9, 47.7) | 13.0 (11.2, 15.1) | 0.419 | |
| Female | 63.1 (61.6, 64.6) | 36.9 (35.4, 38.4) | 39.7 (37.5, 41.9) | 46.8 (44.6, 48.9) | 13.5 (12.2, 15.0) | |||
| Total | 63.6 (62.1, 65.0) | 36.4 (35.0, 37.9) | 40.4 (38.4, 42.4) | 46.3 (44.6, 48.1) | 13.3 (12.0, 14.7) | |||
| rs1208 | A | G | AA | AG | GG | |||
| Male | 59.8 (58.2, 61.3) | 40.2 (38.7, 41.8) | 0.108 | 35.8 (33.6, 38.1) | 47.8 (45.2, 50.5) | 16.3 (14.6, 18.2) | 0.245 | |
| Female | 61.5 (60.2, 62.7) | 38.5 (37.3, 39.8) | 38.5 (36.6, 40.5) | 45.9 (43.5, 48.4) | 15.6 (14.1, 17.1) | |||
| Total | 60.6 (59.8, 61.5) | 39.4 (38.5, 40.2) | 37.2 (35.9, 38.5) | 46.8 (45.4, 48.2) | 15.9 (15.1, 16.8) | |||
| rs1799930 | A | G | AA | AG | GG | |||
| Male | 29.7 (28.0, 31.4) | 70.3 (68.6, 72.0) | 0.154 | 8.2 (7.0, 9.6) | 42.9 (40.5, 45.3) | 48.9 (46.3, 51.5) | 0.128 | |
| Female | 30.7 (29.4, 32.0) | 69.3 (68.0, 70.6) | 9.5 (8.4, 10.9) | 42.3 (40.0, 44.7) | 48.1 (46.0, 50.3) | |||
| Total | 30.2 (28.9, 31.5) | 69.8 (68.5, 71.1) | 8.9 (7.9, 10.1) | 42.6 (40.8, 44.5) | 48.5 (46.5, 50.5) | |||
| rs1801279 | A | G | AA | AG | GG | |||
| Male | 0.9 (0.7, 1.1) | 99.1 (98.9, 99.3) | 0.053 | 0.0 (0.0, 0.2) | 1.7 (1.3, 2.2) | 98.3 (97.8, 98.7) | 0.191 | |
| Female | 1.2 (0.9, 1.6) | 98.8 (98.4, 99.1) | 0.1 (0.0, 0.2) | 2.3 (1.6, 3.2) | 97.7 (96.8, 98.3) | |||
| Total | 1.0 (0.8, 1.3) | 99.0 (98.7, 99.2) | 0.0 (0.0, 0.1) | 2.0 (1.5, 2.6) | 98.0 (97.4, 98.4) | |||
| rs1801280 | C | T | CC | CT | TT | |||
| Male | 39.8 (38.1, 41.6) | 60.2 (58.4, 61.9) | 0.092 | 16.2 (14.5, 18.0) | 47.2 (44.7, 49.8) | 36.6 (34.1, 39.2) | 0.281 | |
| Female | 38.0 (36.7, 39.4) | 62.0 (60.6, 63.3) | 15.2 (13.8, 16.7) | 45.7 (43.1, 48.4) | 39.1 (36.9, 41.4) | |||
| Total | 38.9 (37.8, 40.0) | 61.1 (60.0, 62.2) | 15.7 (14.5, 16.8) | 46.5 (44.7, 48.2) | 37.9 (36.2, 39.6) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1041983 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 62.6 (58.1, 66.9) | 37.4 (33.1, 41.9) | 37.4 (29.6, 46.0) | 50.3 (39.5, 61.2) | 12.2 (7.7, 18.9) | |
| 20-39 | 64.5 (61.9, 67.1) | 35.5 (32.9, 38.1) | 41.7 (38.3, 45.2) | 45.7 (42.4, 49.0) | 12.6 (10.1, 15.6) | ||
| 40-59 | 65.1 (61.7, 68.3) | 34.9 (31.7, 38.3) | 41.5 (36.7, 46.5) | 47.1 (41.6, 52.6) | 11.4 (8.2, 15.7) | ||
| >=60 | 65.1 (62.3, 67.7) | 34.9 (32.3, 37.7) | 42.9 (38.2, 47.8) | 44.2 (39.1, 49.5) | 12.8 (10.8, 15.2) | ||
| Non-Hispanic Black | 12-19 | 53.8 (48.4, 59.1) | 46.2 (40.9, 51.6) | 30.6 (24.8, 37.2) | 46.3 (41.6, 51.1) | 23.1 (18.0, 29.0) | |
| 20-39 | 53.6 (51.7, 55.6) | 46.4 (44.4, 48.3) | 30.5 (28.1, 32.9) | 46.3 (43.1, 49.7) | 23.2 (20.6, 26.0) | ||
| 40-59 | 54.2 (49.5, 58.8) | 45.8 (41.2, 50.5) | 31.1 (25.8, 36.8) | 46.2 (41.8, 50.7) | 22.7 (18.3, 27.9) | ||
| >=60 | 54.5 (47.9, 60.9) | 45.5 (39.1, 52.1) | 31.8 (24.8, 39.8) | 45.3 (38.6, 52.2) | 22.9 (16.4, 30.9) | ||
| Mexican American | 12-19 | 69.8 (64.0, 75.0) | 30.2 (25.0, 36.0) | 50.6 (42.2, 58.9) | 38.4 (30.3, 47.2) | 11.0 (6.9, 17.1) | |
| 20-39 | 68.1 (64.9, 71.1) | 31.9 (28.9, 35.1) | 46.8 (42.5, 51.2) | 42.6 (38.8, 46.4) | 10.6 (8.1, 13.7) | ||
| 40-59 | 67.8 (63.9, 71.4) | 32.2 (28.6, 36.1) | 44.9 (39.2, 50.7) | 45.7 (40.2, 51.3) | 9.4 (6.7, 13.0) | ||
| >=60 | 65.1 (61.7, 68.4) | 34.9 (31.6, 38.3) | 41.6 (35.6, 47.8) | 47.2 (40.6, 53.8) | 11.3 (8.9, 14.2) | ||
| rs1208 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 60.4 (56.5, 64.2) | 39.6 (35.8, 43.5) | 36.4 (30.3, 43.0) | 48.1 (41.3, 54.8) | 15.5 (12.3, 19.4) | |
| 20-39 | 58.5 (55.4, 61.6) | 41.5 (38.4, 44.6) | 33.5 (28.6, 38.9) | 49.9 (44.9, 55.0) | 16.5 (14.3, 19.0) | ||
| 40-59 | 58.7 (55.9, 61.5) | 41.3 (38.5, 44.1) | 34.3 (30.2, 38.7) | 48.8 (42.8, 54.9) | 16.9 (13.2, 21.2) | ||
| >=60 | 59.2 (56.8, 61.5) | 40.8 (38.5, 43.2) | 35.4 (33.5, 37.4) | 47.5 (44.6, 50.4) | 17.1 (14.0, 20.7) | ||
| Non-Hispanic Black | 12-19 | 61.8 (56.4, 67.0) | 38.2 (33.0, 43.6) | 40.0 (33.7, 46.6) | 43.7 (39.3, 48.2) | 16.3 (12.0, 21.8) | |
| 20-39 | 61.7 (59.6, 63.7) | 38.3 (36.3, 40.4) | 40.0 (36.7, 43.3) | 43.4 (39.6, 47.3) | 16.6 (14.4, 19.0) | ||
| 40-59 | 62.2 (58.8, 65.4) | 37.8 (34.6, 41.2) | 39.3 (34.5, 44.2) | 45.8 (40.7, 51.0) | 14.9 (11.8, 18.7) | ||
| >=60 | 60.9 (56.3, 65.4) | 39.1 (34.6, 43.7) | 36.1 (29.2, 43.6) | 49.7 (41.8, 57.6) | 14.2 (10.3, 19.4) | ||
| Mexican American | 12-19 | 64.8 (60.6, 68.7) | 35.2 (31.3, 39.4) | 40.9 (36.5, 45.6) | 47.6 (41.0, 54.3) | 11.4 (6.8, 18.7) | |
| 20-39 | 63.2 (59.9, 66.5) | 36.8 (33.5, 40.1) | 39.7 (34.7, 45.0) | 47.0 (42.5, 51.6) | 13.3 (11.0, 15.9) | ||
| 40-59 | 67.3 (65.0, 69.5) | 32.7 (30.5, 35.0) | 44.8 (40.1, 49.5) | 45.1 (38.9, 51.4) | 10.2 (7.7, 13.3) | ||
| >=60 | 62.3 (56.6, 67.7) | 37.7 (32.3, 43.4) | 42.1 (36.8, 47.5) | 40.5 (35.0, 46.3) | 17.4 (11.5, 25.6) | ||
| rs1799930 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 33.7 (28.9, 38.9) | 66.3 (61.1, 71.1) | 10.7 (7.1, 15.8) | 46.0 (37.2, 55.1) | 43.3 (35.0, 52.0) | |
| 20-39 | 32.4 (29.7, 35.3) | 67.6 (64.7, 70.3) | 10.4 (8.0, 13.5) | 44.0 (40.6, 47.4) | 45.6 (41.9, 49.4) | ||
| 40-59 | 31.8 (29.1, 34.6) | 68.2 (65.4, 70.9) | 9.0 (6.3, 12.7) | 45.5 (39.9, 51.3) | 45.4 (40.8, 50.1) | ||
| >=60 | 32.0 (30.0, 34.1) | 68.0 (65.9, 70.0) | 10.7 (8.9, 12.9) | 42.6 (38.1, 47.2) | 46.7 (42.9, 50.5) | ||
| Non-Hispanic Black | 12-19 | 28.1 (23.3, 33.5) | 71.9 (66.5, 76.7) | 9.8 (6.6, 14.5) | 36.6 (30.8, 42.9) | 53.6 (46.1, 60.9) | |
| 20-39 | 27.9 (25.3, 30.7) | 72.1 (69.3, 74.7) | 8.9 (6.7, 11.6) | 38.1 (35.5, 40.9) | 53.0 (49.5, 56.5) | ||
| 40-59 | 26.9 (23.1, 31.1) | 73.1 (68.9, 76.9) | 6.2 (4.4, 8.6) | 41.4 (34.2, 49.0) | 52.4 (44.9, 59.7) | ||
| >=60 | 29.8 (25.4, 34.6) | 70.2 (65.4, 74.6) | 10.9 (6.9, 16.8) | 37.8 (30.7, 45.5) | 51.3 (44.6, 58.0) | ||
| Mexican American | 12-19 | 16.8 (13.1, 21.3) | 83.2 (78.7, 86.9) | 3.2 (1.7, 5.8) | 27.3 (20.5, 35.2) | 69.6 (61.5, 76.6) | |
| 20-39 | 17.8 (15.6, 20.2) | 82.2 (79.8, 84.4) | 2.9 (1.6, 5.3) | 29.8 (25.7, 34.2) | 67.3 (63.1, 71.2) | ||
| 40-59 | 18.2 (14.9, 22.0) | 81.8 (78.0, 85.1) | 3.4 (1.5, 7.5) | 29.6 (24.2, 35.6) | 67.0 (60.9, 72.7) | ||
| >=60 | 21.0 (17.1, 25.6) | 79.0 (74.4, 82.9) | 4.7 (2.8, 7.6) | 32.6 (25.0, 41.3) | 62.7 (54.3, 70.3) | ||
| rs1801279 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 0.0 (NA) | 100.0 (NA) | 0.0 (NA) | 0.0 (NA) | 100.0 (NA) | |
| 20-39 | 0.0 (NA) | 100.0 (NA) | 0.0 (NA) | 0.0 (NA) | 100.0 (NA) | ||
| 40-59 | 0.1 (0.0, 0.5) | 99.9 (99.5, 100.0) | 0.0 (NA) | 0.1 (0.0, 1.0) | 99.9 (99.0, 100.0) | ||
| >=60 | 0.1 (0.0, 0.3) | 99.9 (99.7, 100.0) | 0.0 (NA) | 0.2 (0.1, 0.7) | 99.8 (99.3, 99.9) | ||
| Non-Hispanic Black | 12-19 | 7.7 (5.3, 11.2) | 92.3 (88.8, 94.7) | 0.6 (0.1, 3.9) | 14.3 (10.6, 19.0) | 85.1 (79.5, 89.4) | |
| 20-39 | 7.8 (6.6, 9.3) | 92.2 (90.7, 93.4) | 0.4 (0.1, 1.5) | 14.8 (12.4, 17.5) | 84.8 (82.1, 87.2) | ||
| 40-59 | 8.6 (6.9, 10.6) | 91.4 (89.4, 93.1) | 0.2 (0.0, 1.5) | 16.7 (13.1, 21.0) | 83.1 (78.9, 86.6) | ||
| >=60 | 6.6 (5.4, 8.2) | 93.4 (91.8, 94.6) | 0.2 (0.0, 2.1) | 12.8 (10.1, 16.1) | 87.0 (83.8, 89.6) | ||
| Mexican American | 12-19 | 0.6 (0.2, 1.7) | 99.4 (98.3, 99.8) | 0.0 (NA) | 1.2 (0.5, 3.3) | 98.8 (96.7, 99.5) | |
| 20-39 | 0.4 (0.2, 0.9) | 99.6 (99.1, 99.8) | 0.0 (NA) | 0.7 (0.3, 1.8) | 99.3 (98.2, 99.7) | ||
| 40-59 | 0.7 (0.3, 1.9) | 99.3 (98.1, 99.7) | 0.0 (NA) | 1.5 (0.5, 3.8) | 98.5 (96.2, 99.5) | ||
| >=60 | 0.5 (0.2, 1.2) | 99.5 (98.8, 99.8) | 0.1 (0.0, 0.7) | 0.8 (0.2, 3.6) | 99.1 (97.2, 99.7) | ||
| rs1801280 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 40.4 (36.7, 44.2) | 59.6 (55.8, 63.3) | 14.1 (10.1, 19.2) | 52.7 (45.2, 60.0) | 33.3 (27.5, 39.5) | |
| 20-39 | 42.5 (39.3, 45.7) | 57.5 (54.3, 60.7) | 17.3 (14.8, 20.1) | 50.3 (46.3, 54.3) | 32.4 (28.0, 37.2) | ||
| 40-59 | 42.2 (39.4, 45.0) | 57.8 (55.0, 60.6) | 17.8 (14.1, 22.1) | 48.8 (43.6, 54.1) | 33.4 (29.8, 37.2) | ||
| >=60 | 42.4 (39.6, 45.3) | 57.6 (54.7, 60.4) | 19.2 (15.6, 23.4) | 46.5 (42.8, 50.3) | 34.3 (31.5, 37.2) | ||
| Non-Hispanic Black | 12-19 | 28.8 (24.4, 33.5) | 71.2 (66.5, 75.6) | 9.0 (6.1, 12.9) | 39.6 (34.7, 44.7) | 51.5 (44.9, 58.0) | |
| 20-39 | 30.2 (28.3, 32.2) | 69.8 (67.8, 71.7) | 10.5 (8.3, 13.2) | 39.4 (35.9, 43.0) | 50.1 (47.2, 53.0) | ||
| 40-59 | 28.3 (25.7, 31.1) | 71.7 (68.9, 74.3) | 8.6 (6.3, 11.5) | 39.5 (33.9, 45.5) | 51.9 (46.9, 56.9) | ||
| >=60 | 28.7 (25.8, 31.8) | 71.3 (68.2, 74.2) | 6.1 (3.0, 12.1) | 45.2 (36.4, 54.4) | 48.7 (42.3, 55.0) | ||
| Mexican American | 12-19 | 32.1 (27.3, 37.4) | 67.9 (62.6, 72.7) | 9.1 (4.5, 17.5) | 46.1 (40.8, 51.5) | 44.8 (39.7, 50.0) | |
| 20-39 | 33.2 (30.1, 36.6) | 66.8 (63.4, 69.9) | 10.7 (8.2, 13.8) | 45.1 (40.8, 49.6) | 44.2 (39.5, 49.1) | ||
| 40-59 | 30.1 (26.0, 34.6) | 69.9 (65.4, 74.0) | 8.5 (5.8, 12.3) | 43.2 (37.4, 49.1) | 48.3 (41.7, 55.0) | ||
| >=60 | 33.5 (28.8, 38.5) | 66.5 (61.5, 71.2) | 13.8 (9.3, 19.8) | 39.3 (34.2, 44.7) | 46.9 (41.1, 52.7) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1041983 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 65.2 (63.3, 67.1) | 34.8 (32.9, 36.7) | 42.0 (39.4, 44.7) | 46.4 (43.7, 49.1) | 11.6 (9.7, 13.7) | |
| Female | 63.9 (61.9, 65.9) | 36.1 (34.1, 38.1) | 40.8 (37.6, 44.1) | 46.2 (43.1, 49.4) | 12.9 (11.4, 14.7) | ||
| Non-Hispanic Black | Male | 53.6 (50.2, 56.9) | 46.4 (43.1, 49.8) | 31.1 (27.0, 35.5) | 45.0 (41.3, 48.9) | 23.9 (20.6, 27.5) | |
| Female | 54.2 (52.6, 55.7) | 45.8 (44.3, 47.4) | 30.6 (28.7, 32.6) | 47.1 (44.4, 49.8) | 22.3 (20.2, 24.5) | ||
| Mexican American | Male | 67.7 (64.7, 70.6) | 32.3 (29.4, 35.3) | 45.6 (41.6, 49.8) | 44.2 (41.1, 47.3) | 10.2 (8.0, 12.8) | |
| Female | 68.5 (65.8, 71.2) | 31.5 (28.8, 34.2) | 47.9 (44.1, 51.6) | 41.3 (37.7, 45.1) | 10.8 (8.4, 13.8) | ||
| rs1208 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 58.4 (56.5, 60.2) | 41.6 (39.8, 43.5) | 33.4 (30.5, 36.4) | 50.0 (46.7, 53.2) | 16.6 (14.8, 18.7) | |
| Female | 59.5 (57.7, 61.3) | 40.5 (38.7, 42.3) | 35.6 (33.7, 37.6) | 47.8 (44.9, 50.7) | 16.6 (14.2, 19.4) | ||
| Non-Hispanic Black | Male | 61.9 (59.5, 64.4) | 38.1 (35.6, 40.5) | 39.9 (36.3, 43.7) | 44.1 (39.9, 48.3) | 16.0 (13.5, 18.9) | |
| Female | 61.5 (59.9, 63.2) | 38.5 (36.8, 40.1) | 38.7 (36.4, 41.1) | 45.7 (43.3, 48.0) | 15.6 (14.0, 17.4) | ||
| Mexican American | Male | 64.7 (61.4, 67.9) | 35.3 (32.1, 38.6) | 41.4 (37.2, 45.6) | 46.7 (43.1, 50.4) | 11.9 (9.1, 15.5) | |
| Female | 63.9 (61.6, 66.1) | 36.1 (33.9, 38.4) | 41.1 (37.8, 44.5) | 45.6 (42.7, 48.6) | 13.3 (11.6, 15.2) | ||
| rs1799930 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 31.7 (29.9, 33.6) | 68.3 (66.4, 70.1) | 9.2 (7.6, 11.0) | 45.1 (42.4, 47.8) | 45.7 (43.0, 48.5) | |
| Female | 32.9 (30.7, 35.1) | 67.1 (64.9, 69.3) | 11.0 (9.4, 12.9) | 43.7 (40.7, 46.7) | 45.3 (42.0, 48.6) | ||
| Non-Hispanic Black | Male | 28.7 (25.4, 32.3) | 71.3 (67.7, 74.6) | 9.6 (7.5, 12.2) | 38.2 (33.5, 43.2) | 52.2 (46.6, 57.7) | |
| Female | 27.4 (25.8, 29.0) | 72.6 (71.0, 74.2) | 7.9 (6.5, 9.6) | 38.9 (35.8, 42.1) | 53.2 (50.4, 55.9) | ||
| Mexican American | Male | 18.1 (16.2, 20.3) | 81.9 (79.7, 83.8) | 3.1 (1.8, 5.2) | 30.1 (26.7, 33.9) | 66.8 (63.2, 70.2) | |
| Female | 17.8 (14.9, 21.1) | 82.2 (78.9, 85.1) | 3.4 (2.0, 5.7) | 28.8 (24.8, 33.1) | 67.8 (62.7, 72.6) | ||
| rs1801279 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 0.0 (0.0, 0.3) | 100.0 (99.7, 100.0) | 0.0 (NA) | 0.1 (0.0, 0.6) | 99.9 (99.4, 100.0) | |
| Female | 0.0 (0.0, 0.1) | 100.0 (99.9, 100.0) | 0.0 (NA) | 0.1 (0.0, 0.3) | 99.9 (99.7, 100.0) | ||
| Non-Hispanic Black | Male | 7.5 (6.6, 8.5) | 92.5 (91.5, 93.4) | 0.3 (0.1, 1.6) | 14.4 (12.6, 16.4) | 85.3 (83.4, 87.1) | |
| Female | 8.1 (6.9, 9.5) | 91.9 (90.5, 93.1) | 0.4 (0.1, 1.2) | 15.3 (12.8, 18.3) | 84.3 (81.4, 86.7) | ||
| Mexican American | Male | 0.5 (0.2, 1.2) | 99.5 (98.8, 99.8) | 0.0 (0.0, 0.1) | 1.1 (0.5, 2.4) | 98.9 (97.6, 99.5) | |
| Female | 0.5 (0.2, 1.0) | 99.5 (99.0, 99.8) | 0.0 (NA) | 0.9 (0.4, 2.0) | 99.1 (98.0, 99.6) | ||
| rs1801280 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 42.5 (40.5, 44.5) | 57.5 (55.5, 59.5) | 17.5 (15.6, 19.6) | 50.0 (46.8, 53.3) | 32.5 (29.5, 35.6) | |
| Female | 41.8 (40.0, 43.5) | 58.2 (56.5, 60.0) | 17.4 (15.0, 20.1) | 48.7 (45.6, 51.8) | 33.9 (31.9, 36.0) | ||
| Non-Hispanic Black | Male | 30.2 (28.1, 32.5) | 69.8 (67.5, 71.9) | 10.2 (8.7, 11.9) | 40.0 (36.2, 44.0) | 49.8 (46.0, 53.5) | |
| Female | 28.5 (26.5, 30.5) | 71.5 (69.5, 73.5) | 8.2 (6.5, 10.4) | 40.4 (37.6, 43.3) | 51.3 (48.4, 54.2) | ||
| Mexican American | Male | 31.6 (28.2, 35.2) | 68.4 (64.8, 71.8) | 9.7 (7.0, 13.2) | 43.8 (41.1, 46.5) | 46.5 (42.2, 50.9) | |
| Female | 33.2 (30.3, 36.2) | 66.8 (63.8, 69.7) | 10.6 (8.6, 13.1) | 45.1 (40.9, 49.4) | 44.3 (39.7, 48.9) | ||
- Page last reviewed: March 16, 2009 (archived document)
- Content source: