MTRR Allele and Genotype Frequencies
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Available polymorphism(s)
|
rs number |
Common Designations
Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs1801394 |
Ex2-64A>G |
Ile22Met |
TaqMan |
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs1801394 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 47.2 (45.9, 48.5) | 52.8 (51.5, 54.1) | <0.001 | 22.6 (20.9, 24.4) | 49.1 (47.1, 51.1) | 28.3 (26.7, 29.9) | <0.001 | 0.74 | |
| Non-Hispanic Black | 71.3 (69.1, 73.3) | 28.7 (26.7, 30.9) | 50.7 (47.8, 53.6) | 41.1 (39.2, 43.1) | 8.2 (6.8, 9.8) | 0.82 | |||
| Mexican American | 73.9 (72.0, 75.8) | 26.1 (24.2, 28.0) | 55.0 (51.8, 58.1) | 37.9 (34.7, 41.3) | 7.1 (5.7, 8.9) | 0.04 | |||
| Total* | 53.1 (51.5, 54.7) | 46.9 (45.3, 48.5) | 29.8 (27.7, 31.9) | 46.7 (45.0, 48.5) | 23.5 (22.0, 25.0) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1801394 | A | G | AA | AG | GG | |||
| 12-19 | 57.3 (51.0, 63.3) | 42.7 (36.7, 49.0) | 0.015 | 34.2 (27.9, 41.2) | 46.1 (41.6, 50.6) | 19.7 (14.0, 27.0) | 0.060 | |
| 20-39 | 53.8 (51.4, 56.2) | 46.2 (43.8, 48.6) | 29.5 (26.0, 33.2) | 48.6 (45.0, 52.2) | 21.9 (19.7, 24.3) | |||
| 40-59 | 53.9 (50.7, 57.2) | 46.1 (42.8, 49.3) | 32.1 (27.5, 37.1) | 43.7 (38.2, 49.3) | 24.2 (20.7, 28.1) | |||
| >=60 | 47.8 (45.2, 50.3) | 52.2 (49.7, 54.8) | 23.9 (20.8, 27.4) | 47.7 (44.4, 50.9) | 28.4 (25.7, 31.2) | |||
| Total | 53.1 (51.5, 54.7) | 46.9 (45.3, 48.5) | 29.8 (27.7, 31.9) | 46.7 (45.0, 48.5) | 23.5 (22.0, 25.0) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1801394 | A | G | AA | AG | GG | |||
| Male | 53.5 (50.7, 56.3) | 46.5 (43.7, 49.3) | 0.604 | 29.3 (26.3, 32.6) | 48.4 (45.5, 51.2) | 22.3 (19.3, 25.5) | 0.335 | |
| Female | 52.8 (51.4, 54.2) | 47.2 (45.8, 48.6) | 30.2 (28.2, 32.4) | 45.2 (42.3, 48.0) | 24.6 (22.8, 26.6) | |||
| Total | 53.1 (51.5, 54.7) | 46.9 (45.3, 48.5) | 29.8 (27.7, 31.9) | 46.7 (45.0, 48.5) | 23.5 (22.0, 25.0) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1801394 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 49.7 (42.6, 56.8) | 50.3 (43.2, 57.4) | 25.4 (18.5, 33.8) | 48.6 (42.1, 55.1) | 26.0 (18.8, 34.8) | |
| 20-39 | 46.5 (43.6, 49.5) | 53.5 (50.5, 56.4) | 20.1 (15.9, 25.0) | 52.9 (47.8, 57.9) | 27.0 (24.0, 30.3) | ||
| 40-59 | 49.8 (45.9, 53.7) | 50.2 (46.3, 54.1) | 27.2 (21.7, 33.6) | 45.1 (38.7, 51.7) | 27.6 (23.8, 31.9) | ||
| >=60 | 43.5 (40.9, 46.0) | 56.5 (54.0, 59.1) | 19.4 (16.4, 22.7) | 48.2 (44.6, 51.9) | 32.4 (29.4, 35.6) | ||
| Non-Hispanic Black | 12-19 | 70.1 (66.5, 73.5) | 29.9 (26.5, 33.5) | 50.9 (46.2, 55.5) | 38.5 (34.7, 42.4) | 10.6 (7.8, 14.4) | |
| 20-39 | 69.6 (66.5, 72.5) | 30.4 (27.5, 33.5) | 47.2 (42.8, 51.8) | 44.7 (40.8, 48.6) | 8.1 (6.1, 10.7) | ||
| 40-59 | 74.0 (69.5, 78.0) | 26.0 (22.0, 30.5) | 56.1 (49.7, 62.3) | 35.8 (30.9, 41.0) | 8.2 (5.5, 11.9) | ||
| >=60 | 73.1 (70.1, 76.0) | 26.9 (24.0, 29.9) | 51.5 (47.6, 55.3) | 43.3 (39.5, 47.3) | 5.2 (2.8, 9.4) | ||
| Mexican American | 12-19 | 73.8 (68.5, 78.5) | 26.2 (21.5, 31.5) | 54.2 (46.5, 61.7) | 39.2 (32.5, 46.4) | 6.6 (3.5, 12.1) | |
| 20-39 | 74.6 (72.1, 76.9) | 25.4 (23.1, 27.9) | 55.8 (50.9, 60.6) | 37.6 (32.2, 43.3) | 6.6 (5.0, 8.8) | ||
| 40-59 | 72.8 (69.8, 75.6) | 27.2 (24.4, 30.2) | 54.6 (50.9, 58.4) | 36.4 (32.8, 40.1) | 9.0 (6.3, 12.6) | ||
| >=60 | 73.1 (69.7, 76.3) | 26.9 (23.7, 30.3) | 52.8 (48.1, 57.4) | 40.7 (36.1, 45.6) | 6.5 (3.8, 10.9) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1801394 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 48.0 (45.7, 50.3) | 52.0 (49.7, 54.3) | 22.3 (19.9, 24.9) | 51.4 (47.9, 54.9) | 26.3 (23.3, 29.6) | |
| Female | 46.4 (44.6, 48.3) | 53.6 (51.7, 55.4) | 23.0 (21.0, 25.1) | 46.9 (43.4, 50.5) | 30.1 (27.2, 33.1) | ||
| Non-Hispanic Black | Male | 71.0 (68.0, 73.9) | 29.0 (26.1, 32.0) | 50.3 (45.8, 54.9) | 41.4 (37.8, 45.1) | 8.3 (6.5, 10.4) | |
| Female | 71.5 (69.2, 73.6) | 28.5 (26.4, 30.8) | 51.0 (48.0, 54.0) | 40.9 (38.5, 43.4) | 8.1 (6.4, 10.1) | ||
| Mexican American | Male | 74.3 (71.0, 77.4) | 25.7 (22.6, 29.0) | 55.5 (49.6, 61.3) | 37.6 (32.0, 43.5) | 6.9 (5.4, 8.8) | |
| Female | 73.5 (71.4, 75.5) | 26.5 (24.5, 28.6) | 54.4 (51.7, 57.1) | 38.2 (36.0, 40.5) | 7.4 (5.7, 9.5) | ||
- Page last reviewed: March 16, 2009 (archived document)
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