MBL2 Allele and Genotype Frequencies
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Available polymorphism(s)
|
rs number |
Common Designations Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs11003125 |
-618G>C |
TaqMan |
|
|
rs1800450 |
Ex1-27G>A |
Gly54Asp |
TaqMan |
|
rs1800451 |
Ex1-18G>A |
Gly57Glu |
TaqMan |
|
rs5030737 |
Ex1-34C>T |
Arg52Cys |
TaqMan |
|
rs7096206 |
-289G<C |
TaqMan |
|
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs11003125 | C | G | CC | CG | GG | ||||
| Non-Hispanic White | 63.6 (61.9, 65.3) | 36.4 (34.7, 38.1) | <0.001 | 40.9 (38.6, 43.2) | 45.6 (42.5, 48.6) | 13.6 (11.4, 16.1) | <0.001 | 0.76 | |
| Non-Hispanic Black | 87.2 (86.0, 88.3) | 12.8 (11.7, 14.0) | 76.2 (73.9, 78.3) | 21.9 (19.8, 24.3) | 1.9 (1.3, 2.7) | 0.71 | |||
| Mexican American | 49.0 (46.9, 51.1) | 51.0 (48.9, 53.1) | 25.0 (22.3, 27.8) | 48.1 (46.3, 50.0) | 26.9 (25.2, 28.7) | 0.44 | |||
| Total* | 65.1 (63.3, 66.8) | 34.9 (33.2, 36.7) | 43.2 (41.0, 45.4) | 43.8 (41.3, 46.2) | 13.1 (11.2, 15.2) | ||||
| rs1800450 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 14.6 (13.1, 16.2) | 85.4 (83.8, 86.9) | <0.001 | 2.8 (2.1, 3.7) | 23.5 (21.1, 26.1) | 73.7 (70.8, 76.3) | <0.001 | 0.01 | |
| Non-Hispanic Black | 4.0 (3.3, 4.9) | 96.0 (95.1, 96.7) | 0.4 (0.2, 0.8) | 7.4 (6.0, 9.0) | 92.3 (90.6, 93.6) | 0.02 | |||
| Mexican American | 14.6 (12.9, 16.6) | 85.4 (83.4, 87.1) | 2.0 (1.3, 3.2) | 25.1 (22.8, 27.6) | 72.8 (69.7, 75.7) | 0.66 | |||
| Total* | 13.5 (12.3, 14.7) | 86.5 (85.3, 87.7) | 2.4 (1.9, 3.1) | 22.1 (20.3, 24.0) | 75.5 (73.4, 77.5) | ||||
| rs1800451 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 2.0 (1.6, 2.4) | 98.0 (97.6, 98.4) | <0.001 | 0.1 (0.0, 0.3) | 3.8 (3.1, 4.7) | 96.1 (95.2, 96.9) | <0.001 | 0.16 | |
| Non-Hispanic Black | 23.3 (21.7, 25.0) | 76.7 (75.0, 78.3) | 6.1 (4.6, 7.9) | 34.4 (32.3, 36.7) | 59.5 (57.2, 61.8) | 0.12 | |||
| Mexican American | 2.5 (1.9, 3.3) | 97.5 (96.7, 98.1) | 0.0 (NA) | 5.1 (3.9, 6.6) | 94.9 (93.4, 96.1) | 0.23 | |||
| Total* | 4.6 (3.9, 5.5) | 95.4 (94.5, 96.1) | 0.8 (0.6, 1.2) | 7.6 (6.3, 9.2) | 91.6 (90.0, 93.0) | ||||
| rs5030737 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 92.6 (91.5, 93.6) | 7.4 (6.4, 8.5) | <0.001 | 85.9 (83.7, 87.9) | 13.3 (11.3, 15.6) | 0.8 (0.4, 1.3) | <0.001 | 0.27 | |
| Non-Hispanic Black | 98.9 (98.5, 99.2) | 1.1 (0.8, 1.5) | 97.7 (97.0, 98.3) | 2.3 (1.7, 3.0) | 0.0 (NA) | 0.63 | |||
| Mexican American | 97.1 (96.5, 97.6) | 2.9 (2.4, 3.5) | 94.4 (93.2, 95.3) | 5.5 (4.6, 6.5) | 0.2 (0.1, 0.4) | <0.01 | |||
| Total* | 93.9 (92.9, 94.7) | 6.1 (5.3, 7.1) | 88.3 (86.5, 89.9) | 11.1 (9.6, 12.9) | 0.6 (0.3, 1.0) | ||||
| rs7096206 | C | G | CC | CG | GG | ||||
| Non-Hispanic White | 22.4 (20.4, 24.5) | 77.6 (75.5, 79.6) | <0.001 | 5.2 (4.1, 6.5) | 34.4 (31.2, 37.6) | 60.4 (56.9, 63.8) | <0.001 | 0.41 | |
| Non-Hispanic Black | 15.1 (13.7, 16.7) | 84.9 (83.3, 86.3) | 2.2 (1.6, 3.0) | 25.8 (23.3, 28.5) | 71.9 (69.1, 74.6) | 0.97 | |||
| Mexican American | 11.4 (9.5, 13.5) | 88.6 (86.5, 90.5) | 2.2 (1.5, 3.4) | 18.3 (15.8, 21.1) | 79.5 (76.0, 82.5) | <0.01 | |||
| Total* | 20.4 (18.9, 22.0) | 79.6 (78.0, 81.1) | 4.4 (3.6, 5.3) | 32.0 (29.7, 34.4) | 63.6 (61.0, 66.2) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs11003125 | C | G | CC | CG | GG | |||
| 12-19 | 65.6 (61.6, 69.4) | 34.4 (30.6, 38.4) | 0.838 | 44.9 (39.9, 50.1) | 41.3 (36.5, 46.3) | 13.7 (10.2, 18.2) | 0.130 | |
| 20-39 | 64.8 (61.6, 67.8) | 35.2 (32.2, 38.4) | 43.8 (40.5, 47.2) | 41.9 (38.8, 45.2) | 14.2 (10.9, 18.3) | |||
| 40-59 | 65.7 (63.6, 67.7) | 34.3 (32.3, 36.4) | 42.0 (38.6, 45.4) | 47.4 (42.9, 52.0) | 10.6 (8.2, 13.5) | |||
| >=60 | 64.3 (61.5, 67.1) | 35.7 (32.9, 38.5) | 42.4 (38.4, 46.5) | 43.9 (40.8, 47.0) | 13.7 (12.0, 15.7) | |||
| Total | 65.1 (63.3, 66.8) | 34.9 (33.2, 36.7) | 43.2 (41.0, 45.4) | 43.8 (41.3, 46.2) | 13.1 (11.2, 15.2) | |||
| rs1800450 | A | G | AA | AG | GG | |||
| 12-19 | 13.8 (11.1, 17.0) | 86.2 (83.0, 88.9) | 0.604 | 3.1 (1.7, 5.6) | 21.4 (16.7, 26.9) | 75.5 (69.9, 80.3) | 0.286 | |
| 20-39 | 12.7 (11.3, 14.3) | 87.3 (85.7, 88.7) | 2.3 (1.7, 3.1) | 20.8 (18.2, 23.6) | 76.9 (73.9, 79.6) | |||
| 40-59 | 14.0 (11.8, 16.5) | 86.0 (83.5, 88.2) | 1.6 (1.0, 2.6) | 24.7 (20.8, 29.1) | 73.7 (69.1, 77.8) | |||
| >=60 | 13.9 (12.5, 15.4) | 86.1 (84.6, 87.5) | 3.2 (1.9, 5.1) | 21.5 (18.9, 24.4) | 75.3 (72.9, 77.6) | |||
| Total | 13.5 (12.3, 14.7) | 86.5 (85.3, 87.7) | 2.4 (1.9, 3.1) | 22.1 (20.3, 24.0) | 75.5 (73.4, 77.5) | |||
| rs1800451 | A | G | AA | AG | GG | |||
| 12-19 | 5.6 (3.7, 8.5) | 94.4 (91.5, 96.3) | 0.085 | 1.3 (0.6, 2.9) | 8.6 (5.6, 13.0) | 90.1 (85.2, 93.5) | 0.125 | |
| 20-39 | 5.1 (4.1, 6.2) | 94.9 (93.8, 95.9) | 0.8 (0.6, 1.2) | 8.5 (6.8, 10.6) | 90.7 (88.5, 92.5) | |||
| 40-59 | 3.7 (3.0, 4.7) | 96.3 (95.3, 97.0) | 0.7 (0.5, 1.1) | 6.1 (4.5, 8.0) | 93.2 (91.3, 94.8) | |||
| >=60 | 4.3 (3.4, 5.3) | 95.7 (94.7, 96.6) | 0.6 (0.3, 1.2) | 7.3 (6.1, 8.8) | 92.1 (90.4, 93.5) | |||
| Total | 4.6 (3.9, 5.5) | 95.4 (94.5, 96.1) | 0.8 (0.6, 1.2) | 7.6 (6.3, 9.2) | 91.6 (90.0, 93.0) | |||
| rs5030737 | C | T | CC | CT | TT | |||
| 12-19 | 92.8 (89.5, 95.1) | 7.2 (4.9, 10.5) | 0.487 | 86.4 (80.8, 90.6) | 12.7 (9.0, 17.7) | 0.8 (0.2, 3.3) | 0.269 | |
| 20-39 | 93.5 (91.7, 94.9) | 6.5 (5.1, 8.3) | 87.7 (84.3, 90.5) | 11.5 (8.8, 15.0) | 0.8 (0.3, 1.7) | |||
| 40-59 | 94.5 (92.8, 95.8) | 5.5 (4.2, 7.2) | 89.2 (86.1, 91.7) | 10.6 (8.2, 13.6) | 0.2 (0.1, 0.9) | |||
| >=60 | 94.4 (93.1, 95.5) | 5.6 (4.5, 6.9) | 89.4 (86.7, 91.6) | 10.0 (7.8, 12.8) | 0.5 (0.3, 1.1) | |||
| Total | 93.9 (92.9, 94.7) | 6.1 (5.3, 7.1) | 88.3 (86.5, 89.9) | 11.1 (9.6, 12.9) | 0.6 (0.3, 1.0) | |||
| rs7096206 | C | G | CC | CG | GG | |||
| 12-19 | 19.5 (17.1, 22.1) | 80.5 (77.9, 82.9) | 0.304 | 3.7 (2.0, 6.7) | 31.7 (27.1, 36.7) | 64.6 (60.2, 68.9) | 0.493 | |
| 20-39 | 19.3 (17.0, 21.8) | 80.7 (78.2, 83.0) | 4.4 (3.4, 5.8) | 29.7 (25.8, 33.9) | 65.8 (61.4, 70.0) | |||
| 40-59 | 21.8 (18.7, 25.3) | 78.2 (74.7, 81.3) | 4.3 (2.7, 6.7) | 35.1 (30.6, 39.8) | 60.6 (55.2, 65.9) | |||
| >=60 | 21.1 (19.2, 23.2) | 78.9 (76.8, 80.8) | 4.9 (3.3, 7.3) | 32.4 (29.2, 35.8) | 62.6 (59.5, 65.7) | |||
| Total | 20.4 (18.9, 22.0) | 79.6 (78.0, 81.1) | 4.4 (3.6, 5.3) | 32.0 (29.7, 34.4) | 63.6 (61.0, 66.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs11003125 | C | G | CC | CG | GG | |||
| Male | 65.0 (62.8, 67.1) | 35.0 (32.9, 37.2) | 0.890 | 42.1 (39.5, 44.7) | 45.8 (43.5, 48.0) | 12.2 (10.1, 14.6) | 0.066 | |
| Female | 65.2 (62.8, 67.4) | 34.8 (32.6, 37.2) | 44.2 (41.2, 47.3) | 41.9 (38.6, 45.2) | 13.9 (11.5, 16.7) | |||
| Total | 65.1 (63.3, 66.8) | 34.9 (33.2, 36.7) | 43.2 (41.0, 45.4) | 43.8 (41.3, 46.2) | 13.1 (11.2, 15.2) | |||
| rs1800450 | A | G | AA | AG | GG | |||
| Male | 13.4 (11.8, 15.2) | 86.6 (84.8, 88.2) | 0.882 | 2.2 (1.6, 3.1) | 22.3 (19.3, 25.5) | 75.5 (72.1, 78.5) | 0.811 | |
| Female | 13.5 (12.4, 14.7) | 86.5 (85.3, 87.6) | 2.5 (1.8, 3.5) | 21.9 (20.3, 23.6) | 75.5 (73.6, 77.4) | |||
| Total | 13.5 (12.3, 14.7) | 86.5 (85.3, 87.7) | 2.4 (1.9, 3.1) | 22.1 (20.3, 24.0) | 75.5 (73.4, 77.5) | |||
| rs1800451 | A | G | AA | AG | GG | |||
| Male | 4.1 (3.3, 4.9) | 95.9 (95.1, 96.7) | 0.021 | 0.9 (0.5, 1.5) | 6.3 (5.1, 7.8) | 92.8 (91.3, 94.1) | 0.008 | |
| Female | 5.1 (4.2, 6.3) | 94.9 (93.7, 95.8) | 0.8 (0.5, 1.1) | 8.8 (7.0, 11.0) | 90.5 (88.2, 92.3) | |||
| Total | 4.6 (3.9, 5.5) | 95.4 (94.5, 96.1) | 0.8 (0.6, 1.2) | 7.6 (6.3, 9.2) | 91.6 (90.0, 93.0) | |||
| rs5030737 | C | T | CC | CT | TT | |||
| Male | 94.1 (92.7, 95.2) | 5.9 (4.8, 7.3) | 0.410 | 88.4 (85.7, 90.7) | 11.4 (9.2, 14.1) | 0.2 (0.1, 0.8) | 0.140 | |
| Female | 93.6 (92.9, 94.3) | 6.4 (5.7, 7.1) | 88.2 (86.6, 89.6) | 10.9 (9.3, 12.8) | 0.9 (0.5, 1.7) | |||
| Total | 93.9 (92.9, 94.7) | 6.1 (5.3, 7.1) | 88.3 (86.5, 89.9) | 11.1 (9.6, 12.9) | 0.6 (0.3, 1.0) | |||
| rs7096206 | C | G | CC | CG | GG | |||
| Male | 20.0 (18.2, 21.9) | 80.0 (78.1, 81.8) | 0.434 | 3.7 (2.4, 5.6) | 32.6 (28.4, 37.2) | 63.7 (59.9, 67.4) | 0.459 | |
| Female | 20.8 (19.0, 22.7) | 79.2 (77.3, 81.0) | 5.1 (3.9, 6.6) | 31.4 (28.6, 34.4) | 63.5 (60.4, 66.5) | |||
| Total | 20.4 (18.9, 22.0) | 79.6 (78.0, 81.1) | 4.4 (3.6, 5.3) | 32.0 (29.7, 34.4) | 63.6 (61.0, 66.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs11003125 | C | G | CC | CG | GG | ||
| Non-Hispanic White | 12-19 | 63.1 (58.5, 67.5) | 36.9 (32.5, 41.5) | 41.3 (36.1, 46.7) | 43.6 (37.7, 49.7) | 15.1 (10.4, 21.5) | |
| 20-39 | 63.5 (59.7, 67.2) | 36.5 (32.8, 40.3) | 42.3 (38.4, 46.2) | 42.5 (38.3, 46.9) | 15.2 (11.1, 20.5) | ||
| 40-59 | 64.7 (62.1, 67.3) | 35.3 (32.7, 37.9) | 39.9 (35.6, 44.4) | 49.6 (44.0, 55.1) | 10.5 (7.8, 14.0) | ||
| >=60 | 62.7 (59.7, 65.5) | 37.3 (34.5, 40.3) | 39.5 (35.4, 43.7) | 46.4 (43.2, 49.6) | 14.1 (12.1, 16.5) | ||
| Non-Hispanic Black | 12-19 | 87.8 (84.5, 90.5) | 12.2 (9.5, 15.5) | 77.3 (71.7, 82.0) | 21.1 (16.9, 26.1) | 1.6 (0.7, 3.5) | |
| 20-39 | 87.9 (86.1, 89.5) | 12.1 (10.5, 13.9) | 76.7 (72.9, 80.1) | 22.4 (18.7, 26.6) | 0.9 (0.3, 2.3) | ||
| 40-59 | 83.8 (80.3, 86.8) | 16.2 (13.2, 19.7) | 71.2 (65.8, 76.0) | 25.4 (21.2, 30.0) | 3.5 (1.9, 6.3) | ||
| >=60 | 89.9 (88.3, 91.3) | 10.1 (8.7, 11.7) | 82.1 (79.1, 84.8) | 15.5 (12.1, 19.6) | 2.4 (1.1, 5.1) | ||
| Mexican American | 12-19 | 50.0 (45.3, 54.8) | 50.0 (45.2, 54.7) | 26.4 (21.1, 32.4) | 47.3 (41.8, 52.8) | 26.3 (21.3, 32.0) | |
| 20-39 | 47.7 (44.6, 50.8) | 52.3 (49.2, 55.4) | 23.0 (19.8, 26.5) | 49.3 (46.9, 51.8) | 27.7 (24.5, 31.1) | ||
| 40-59 | 50.0 (45.5, 54.5) | 50.0 (45.5, 54.5) | 27.1 (20.7, 34.7) | 45.8 (39.0, 52.7) | 27.1 (23.5, 31.1) | ||
| >=60 | 52.5 (47.5, 57.4) | 47.5 (42.6, 52.5) | 27.9 (23.2, 33.2) | 49.1 (43.8, 54.4) | 23.0 (17.4, 29.7) | ||
| rs1800450 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 15.6 (12.1, 19.9) | 84.4 (80.1, 87.9) | 3.9 (1.9, 7.6) | 23.5 (17.1, 31.4) | 72.6 (65.1, 79.0) | |
| 20-39 | 13.7 (11.6, 16.0) | 86.3 (84.0, 88.4) | 2.8 (2.1, 3.9) | 21.7 (18.1, 25.7) | 75.5 (71.3, 79.3) | ||
| 40-59 | 15.1 (12.6, 18.1) | 84.9 (81.9, 87.4) | 1.8 (1.1, 3.1) | 26.6 (22.2, 31.5) | 71.6 (66.3, 76.3) | ||
| >=60 | 14.7 (13.2, 16.4) | 85.3 (83.6, 86.8) | 3.5 (2.2, 5.8) | 22.4 (19.4, 25.8) | 74.0 (71.3, 76.6) | ||
| Non-Hispanic Black | 12-19 | 6.2 (4.4, 8.6) | 93.8 (91.4, 95.6) | 0.7 (0.2, 2.5) | 11.0 (7.7, 15.4) | 88.4 (83.9, 91.7) | |
| 20-39 | 3.4 (2.5, 4.5) | 96.6 (95.5, 97.5) | 0.3 (0.1, 0.9) | 6.2 (4.6, 8.2) | 93.5 (91.5, 95.1) | ||
| 40-59 | 3.8 (2.4, 5.8) | 96.2 (94.2, 97.6) | 0.4 (0.1, 1.9) | 6.6 (4.4, 9.9) | 92.9 (89.4, 95.3) | ||
| >=60 | 3.8 (2.5, 5.7) | 96.2 (94.3, 97.5) | 0.0 (NA) | 7.5 (4.9, 11.4) | 92.5 (88.6, 95.1) | ||
| Mexican American | 12-19 | 13.3 (9.8, 17.9) | 86.7 (82.1, 90.2) | 1.5 (0.7, 3.3) | 23.7 (17.9, 30.6) | 74.9 (67.1, 81.3) | |
| 20-39 | 14.2 (11.9, 16.9) | 85.8 (83.1, 88.1) | 1.9 (0.9, 4.1) | 24.6 (20.7, 28.9) | 73.5 (68.9, 77.6) | ||
| 40-59 | 15.9 (14.0, 18.0) | 84.1 (82.0, 86.0) | 2.7 (1.3, 5.4) | 26.5 (21.8, 31.6) | 70.9 (66.7, 74.7) | ||
| >=60 | 16.8 (14.2, 19.8) | 83.2 (80.2, 85.8) | 2.5 (1.5, 4.0) | 28.7 (23.6, 34.4) | 68.9 (63.2, 74.0) | ||
| rs1800451 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 1.4 (0.8, 2.3) | 98.6 (97.7, 99.2) | 0.0 (NA) | 2.7 (1.6, 4.7) | 97.3 (95.3, 98.4) | |
| 20-39 | 2.4 (1.7, 3.3) | 97.6 (96.7, 98.3) | 0.1 (0.0, 0.6) | 4.5 (3.3, 6.2) | 95.4 (93.6, 96.7) | ||
| 40-59 | 1.2 (0.8, 2.0) | 98.8 (98.0, 99.2) | 0.0 (NA) | 2.5 (1.5, 4.1) | 97.5 (95.9, 98.5) | ||
| >=60 | 2.6 (2.1, 3.2) | 97.4 (96.8, 97.9) | 0.2 (0.0, 1.1) | 4.8 (3.9, 6.0) | 94.9 (93.8, 95.9) | ||
| Non-Hispanic Black | 12-19 | 23.0 (19.4, 27.0) | 77.0 (73.0, 80.6) | 5.6 (3.6, 8.6) | 34.8 (29.0, 41.2) | 59.6 (53.0, 65.9) | |
| 20-39 | 23.2 (21.5, 25.0) | 76.8 (75.0, 78.5) | 6.2 (4.2, 8.9) | 34.1 (29.5, 39.0) | 59.7 (56.3, 63.1) | ||
| 40-59 | 23.4 (20.9, 26.3) | 76.6 (73.7, 79.1) | 6.8 (4.4, 10.2) | 33.4 (29.5, 37.5) | 59.9 (56.0, 63.6) | ||
| >=60 | 23.6 (19.6, 28.2) | 76.4 (71.8, 80.4) | 5.2 (3.0, 9.0) | 36.8 (30.2, 43.9) | 58.0 (50.6, 65.0) | ||
| Mexican American | 12-19 | 2.1 (1.4, 3.1) | 97.9 (96.9, 98.6) | 0.0 (NA) | 4.3 (2.9, 6.2) | 95.7 (93.8, 97.1) | |
| 20-39 | 2.3 (1.5, 3.6) | 97.7 (96.4, 98.5) | 0.0 (NA) | 4.7 (3.0, 7.2) | 95.3 (92.8, 97.0) | ||
| 40-59 | 3.2 (2.2, 4.6) | 96.8 (95.4, 97.8) | 0.0 (NA) | 6.4 (4.4, 9.2) | 93.6 (90.8, 95.6) | ||
| >=60 | 3.0 (2.0, 4.5) | 97.0 (95.5, 98.0) | 0.0 (NA) | 6.0 (4.0, 8.9) | 94.0 (91.1, 96.0) | ||
| rs5030737 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 90.9 (85.9, 94.3) | 9.1 (5.7, 14.1) | 83.1 (74.5, 89.2) | 15.7 (10.1, 23.6) | 1.2 (0.3, 4.9) | |
| 20-39 | 91.6 (89.5, 93.4) | 8.4 (6.6, 10.5) | 84.4 (80.3, 87.7) | 14.6 (11.2, 18.8) | 1.1 (0.5, 2.3) | ||
| 40-59 | 93.6 (91.5, 95.2) | 6.4 (4.8, 8.5) | 87.5 (83.5, 90.7) | 12.2 (9.2, 16.1) | 0.3 (0.1, 1.1) | ||
| >=60 | 93.7 (92.1, 95.0) | 6.3 (5.0, 7.9) | 88.0 (84.8, 90.6) | 11.4 (8.8, 14.7) | 0.6 (0.3, 1.2) | ||
| Non-Hispanic Black | 12-19 | 98.6 (97.6, 99.2) | 1.4 (0.8, 2.4) | 97.2 (95.3, 98.3) | 2.8 (1.7, 4.7) | 0.0 (NA) | |
| 20-39 | 98.8 (98.0, 99.3) | 1.2 (0.7, 2.0) | 97.7 (95.9, 98.7) | 2.3 (1.3, 4.1) | 0.0 (NA) | ||
| 40-59 | 98.8 (98.1, 99.3) | 1.2 (0.7, 1.9) | 97.7 (96.2, 98.6) | 2.3 (1.4, 3.8) | 0.0 (NA) | ||
| >=60 | 99.3 (97.8, 99.8) | 0.7 (0.2, 2.2) | 98.7 (95.6, 99.6) | 1.3 (0.4, 4.4) | 0.0 (NA) | ||
| Mexican American | 12-19 | 95.8 (94.3, 96.9) | 4.2 (3.1, 5.7) | 91.9 (89.6, 93.8) | 7.7 (6.1, 9.7) | 0.4 (0.1, 1.9) | |
| 20-39 | 97.5 (96.3, 98.3) | 2.5 (1.7, 3.7) | 95.1 (92.9, 96.6) | 4.8 (3.3, 6.9) | 0.1 (0.0, 0.6) | ||
| 40-59 | 97.2 (95.8, 98.2) | 2.8 (1.8, 4.2) | 94.4 (91.6, 96.4) | 5.6 (3.6, 8.4) | 0.0 (NA) | ||
| >=60 | 97.7 (95.8, 98.8) | 2.3 (1.2, 4.2) | 95.8 (92.4, 97.7) | 3.8 (2.0, 7.1) | 0.4 (0.1, 2.4) | ||
| rs7096206 | C | G | CC | CG | GG | ||
| Non-Hispanic White | 12-19 | 22.0 (18.2, 26.3) | 78.0 (73.7, 81.8) | 4.7 (2.1, 10.0) | 34.7 (28.3, 41.7) | 60.7 (54.0, 67.0) | |
| 20-39 | 21.6 (18.7, 24.8) | 78.4 (75.2, 81.3) | 5.7 (4.3, 7.6) | 31.7 (26.4, 37.5) | 62.6 (56.8, 68.0) | ||
| 40-59 | 23.7 (19.8, 28.1) | 76.3 (71.9, 80.2) | 4.8 (2.8, 8.1) | 37.8 (32.4, 43.4) | 57.4 (50.8, 63.8) | ||
| >=60 | 22.3 (20.2, 24.4) | 77.7 (75.6, 79.8) | 5.2 (3.4, 7.8) | 34.1 (30.6, 37.9) | 60.7 (57.3, 63.9) | ||
| Non-Hispanic Black | 12-19 | 15.1 (13.0, 17.4) | 84.9 (82.6, 87.0) | 2.0 (1.2, 3.3) | 26.1 (21.6, 31.2) | 71.9 (67.2, 76.2) | |
| 20-39 | 15.1 (12.8, 17.6) | 84.9 (82.4, 87.2) | 1.9 (1.1, 3.2) | 26.3 (22.9, 30.1) | 71.8 (67.5, 75.7) | ||
| 40-59 | 15.4 (13.6, 17.3) | 84.6 (82.7, 86.4) | 3.0 (1.7, 5.3) | 24.7 (21.7, 27.9) | 72.3 (69.2, 75.2) | ||
| >=60 | 15.2 (12.1, 18.9) | 84.8 (81.1, 87.9) | 2.2 (0.9, 5.1) | 26.0 (20.3, 32.7) | 71.8 (65.2, 77.6) | ||
| Mexican American | 12-19 | 12.7 (9.1, 17.6) | 87.3 (82.4, 90.9) | 3.7 (1.7, 8.2) | 18.0 (13.6, 23.3) | 78.3 (71.4, 83.9) | |
| 20-39 | 11.1 (9.0, 13.7) | 88.9 (86.3, 91.0) | 1.9 (1.1, 3.5) | 18.4 (14.8, 22.6) | 79.7 (75.2, 83.5) | ||
| 40-59 | 9.8 (7.3, 12.9) | 90.2 (87.1, 92.7) | 1.6 (0.6, 4.2) | 16.2 (12.2, 21.3) | 82.1 (76.8, 86.5) | ||
| >=60 | 13.8 (11.5, 16.4) | 86.2 (83.6, 88.5) | 2.0 (0.9, 4.7) | 23.5 (19.6, 27.8) | 74.5 (70.1, 78.5) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs11003125 | C | G | CC | CG | GG | ||
| Non-Hispanic White | Male | 64.2 (62.2, 66.2) | 35.8 (33.8, 37.8) | 40.4 (37.9, 42.9) | 47.7 (45.2, 50.3) | 11.9 (9.8, 14.3) | |
| Female | 63.1 (60.7, 65.4) | 36.9 (34.6, 39.3) | 41.3 (38.1, 44.7) | 43.5 (39.1, 48.0) | 15.2 (12.3, 18.6) | ||
| Non-Hispanic Black | Male | 86.3 (84.3, 88.0) | 13.7 (12.0, 15.7) | 74.6 (70.9, 77.9) | 23.4 (19.9, 27.2) | 2.1 (1.2, 3.4) | |
| Female | 87.9 (86.3, 89.3) | 12.1 (10.7, 13.7) | 77.5 (74.3, 80.4) | 20.8 (17.7, 24.3) | 1.7 (1.1, 2.7) | ||
| Mexican American | Male | 48.3 (45.1, 51.5) | 51.7 (48.5, 54.9) | 24.1 (20.2, 28.4) | 48.6 (46.0, 51.1) | 27.4 (24.8, 30.1) | |
| Female | 49.8 (47.7, 51.8) | 50.2 (48.2, 52.3) | 25.9 (22.9, 29.2) | 47.7 (44.1, 51.3) | 26.4 (24.2, 28.7) | ||
| rs1800450 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 14.3 (12.4, 16.6) | 85.7 (83.4, 87.6) | 2.7 (1.9, 3.7) | 23.4 (19.8, 27.5) | 74.0 (69.9, 77.7) | |
| Female | 14.8 (13.2, 16.5) | 85.2 (83.5, 86.8) | 3.0 (2.1, 4.3) | 23.6 (21.4, 25.9) | 73.4 (70.8, 75.9) | ||
| Non-Hispanic Black | Male | 4.5 (3.6, 5.7) | 95.5 (94.3, 96.4) | 0.3 (0.1, 1.1) | 8.4 (6.7, 10.5) | 91.3 (89.1, 93.0) | |
| Female | 3.6 (2.6, 5.0) | 96.4 (95.0, 97.4) | 0.4 (0.1, 1.0) | 6.5 (4.8, 8.8) | 93.1 (90.7, 95.0) | ||
| Mexican American | Male | 14.8 (13.0, 16.8) | 85.2 (83.2, 87.0) | 2.4 (1.4, 4.1) | 24.9 (22.4, 27.6) | 72.7 (69.7, 75.6) | |
| Female | 14.4 (12.0, 17.1) | 85.6 (82.9, 88.0) | 1.7 (0.9, 3.0) | 25.4 (21.6, 29.7) | 72.9 (68.2, 77.2) | ||
| rs1800451 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 1.7 (1.2, 2.4) | 98.3 (97.6, 98.8) | 0.1 (0.0, 0.6) | 3.2 (2.2, 4.7) | 96.7 (95.3, 97.7) | |
| Female | 2.2 (1.6, 3.1) | 97.8 (96.9, 98.4) | 0.1 (0.0, 0.4) | 4.3 (3.1, 5.9) | 95.6 (94.0, 96.8) | ||
| Non-Hispanic Black | Male | 22.5 (19.8, 25.3) | 77.5 (74.7, 80.2) | 6.4 (4.5, 9.2) | 32.0 (28.6, 35.7) | 61.5 (57.5, 65.4) | |
| Female | 24.0 (21.9, 26.1) | 76.0 (73.9, 78.1) | 5.8 (4.2, 7.8) | 36.4 (33.8, 39.1) | 57.8 (54.8, 60.8) | ||
| Mexican American | Male | 2.4 (1.7, 3.3) | 97.6 (96.7, 98.3) | 0.0 (NA) | 4.8 (3.4, 6.7) | 95.2 (93.3, 96.6) | |
| Female | 2.7 (2.1, 3.5) | 97.3 (96.5, 97.9) | 0.0 (NA) | 5.4 (4.1, 6.9) | 94.6 (93.1, 95.9) | ||
| rs5030737 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 93.0 (91.1, 94.5) | 7.0 (5.5, 8.9) | 86.2 (82.6, 89.1) | 13.6 (10.7, 17.1) | 0.2 (0.0, 1.2) | |
| Female | 92.2 (91.2, 93.1) | 7.8 (6.9, 8.8) | 85.6 (83.8, 87.3) | 13.1 (11.2, 15.3) | 1.3 (0.7, 2.4) | ||
| Non-Hispanic Black | Male | 99.2 (98.6, 99.5) | 0.8 (0.5, 1.4) | 98.3 (97.3, 99.0) | 1.7 (1.0, 2.7) | 0.0 (NA) | |
| Female | 98.6 (98.0, 99.1) | 1.4 (0.9, 2.0) | 97.3 (95.9, 98.2) | 2.7 (1.8, 4.1) | 0.0 (NA) | ||
| Mexican American | Male | 97.3 (96.3, 98.1) | 2.7 (1.9, 3.7) | 94.9 (92.9, 96.3) | 5.0 (3.6, 6.8) | 0.2 (0.1, 0.3) | |
| Female | 96.8 (95.8, 97.6) | 3.2 (2.4, 4.2) | 93.8 (91.9, 95.3) | 6.0 (4.5, 7.9) | 0.2 (0.0, 0.7) | ||
| rs7096206 | C | G | CC | CG | GG | ||
| Non-Hispanic White | Male | 21.8 (19.7, 24.0) | 78.2 (76.0, 80.3) | 4.3 (2.5, 7.0) | 35.1 (30.1, 40.4) | 60.7 (56.3, 64.9) | |
| Female | 22.9 (20.5, 25.6) | 77.1 (74.4, 79.5) | 6.1 (4.7, 8.0) | 33.7 (29.6, 38.0) | 60.2 (55.8, 64.5) | ||
| Non-Hispanic Black | Male | 14.2 (12.3, 16.3) | 85.8 (83.7, 87.7) | 1.9 (1.1, 3.2) | 24.5 (21.2, 28.2) | 73.5 (69.8, 77.0) | |
| Female | 15.9 (14.0, 18.1) | 84.1 (81.9, 86.0) | 2.5 (1.7, 3.7) | 26.9 (23.5, 30.6) | 70.6 (66.7, 74.2) | ||
| Mexican American | Male | 10.4 (8.6, 12.7) | 89.6 (87.3, 91.4) | 2.4 (1.5, 3.9) | 16.1 (13.5, 19.1) | 81.5 (77.9, 84.6) | |
| Female | 12.4 (10.1, 15.1) | 87.6 (84.9, 89.9) | 2.1 (1.2, 3.6) | 20.5 (16.9, 24.8) | 77.4 (72.7, 81.4) | ||
- Page last reviewed: March 16, 2009 (archived document)
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