IL4 Allele and Genotype Frequencies
ShareCompartir
This website is archived for historical purposes and is no longer being maintained or updated.
Available polymorphism(s)
|
rs number |
Common Designations
Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs2243248 |
-1098T>G |
TaqMan |
|
|
rs2243250 |
-588C>T |
TaqMan |
|
|
rs2243270 |
IVS2-1297A>G |
TaqMan |
|
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs2243248 | G | T | GG | GT | TT | ||||
| Non-Hispanic White | 7.5 (6.7, 8.4) | 92.5 (91.6, 93.3) | <0.001 | 0.4 (0.2, 0.8) | 14.1 (12.7, 15.7) | 85.4 (83.7, 87.0) | <0.001 | 0.68 | |
| Non-Hispanic Black | 15.7 (14.3, 17.3) | 84.3 (82.7, 85.7) | 2.5 (1.7, 3.5) | 26.6 (24.3, 29.0) | 71.0 (68.3, 73.5) | 0.46 | |||
| Mexican American | 12.0 (10.0, 14.4) | 88.0 (85.6, 90.0) | 1.9 (1.3, 2.8) | 20.3 (17.1, 23.9) | 77.8 (73.7, 81.4) | 0.03 | |||
| Total* | 9.0 (8.1, 9.9) | 91.0 (90.1, 91.9) | 0.8 (0.6, 1.1) | 16.3 (14.8, 18.0) | 82.9 (81.1, 84.5) | ||||
| rs2243250 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 84.0 (82.7, 85.2) | 16.0 (14.8, 17.3) | <0.001 | 70.8 (68.9, 72.6) | 26.4 (24.9, 28.0) | 2.8 (2.0, 4.0) | <0.001 | 0.53 | |
| Non-Hispanic Black | 36.0 (34.2, 37.9) | 64.0 (62.1, 65.8) | 14.1 (12.3, 16.2) | 43.8 (41.0, 46.7) | 42.0 (39.4, 44.7) | 0.03 | |||
| Mexican American | 57.7 (55.6, 59.8) | 42.3 (40.2, 44.4) | 34.3 (30.9, 37.8) | 46.9 (43.3, 50.5) | 18.9 (17.1, 20.7) | 0.07 | |||
| Total* | 74.5 (72.7, 76.2) | 25.5 (23.8, 27.3) | 58.9 (56.6, 61.1) | 31.2 (29.6, 32.9) | 9.9 (8.6, 11.4) | ||||
| rs2243270 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 83.6 (82.4, 84.8) | 16.4 (15.2, 17.6) | <0.001 | 69.9 (68.1, 71.7) | 27.4 (25.8, 29.1) | 2.6 (1.8, 3.8) | <0.001 | 0.71 | |
| Non-Hispanic Black | 36.3 (34.6, 38.1) | 63.7 (61.9, 65.4) | 14.5 (13.4, 15.8) | 43.5 (40.4, 46.7) | 41.9 (38.9, 45.0) | 0.01 | |||
| Mexican American | 58.2 (55.7, 60.7) | 41.8 (39.3, 44.3) | 34.9 (31.5, 38.6) | 46.6 (43.3, 49.9) | 18.5 (16.2, 21.0) | 0.08 | |||
| Total* | 74.3 (72.4, 76.0) | 25.7 (24.0, 27.6) | 58.3 (55.9, 60.7) | 31.8 (30.1, 33.6) | 9.8 (8.4, 11.4) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs2243248 | G | T | GG | GT | TT | |||
| 12-19 | 9.9 (8.1, 11.9) | 90.1 (88.1, 91.9) | 0.114 | 1.1 (0.4, 3.2) | 17.5 (15.1, 20.1) | 81.4 (78.2, 84.2) | 0.045 | |
| 20-39 | 9.5 (7.9, 11.2) | 90.5 (88.8, 92.1) | 0.7 (0.5, 1.0) | 17.4 (14.6, 20.7) | 81.8 (78.5, 84.8) | |||
| 40-59 | 9.2 (7.6, 11.0) | 90.8 (89.0, 92.4) | 0.9 (0.5, 1.8) | 16.4 (13.6, 19.7) | 82.6 (79.3, 85.6) | |||
| >=60 | 7.2 (6.0, 8.5) | 92.8 (91.5, 94.0) | 0.5 (0.2, 1.2) | 13.2 (11.2, 15.6) | 86.2 (83.8, 88.3) | |||
| Total | 9.0 (8.1, 9.9) | 91.0 (90.1, 91.9) | 0.8 (0.6, 1.1) | 16.3 (14.8, 18.0) | 82.9 (81.1, 84.5) | |||
| rs2243250 | C | T | CC | CT | TT | |||
| 12-19 | 71.7 (67.8, 75.4) | 28.3 (24.6, 32.2) | 0.015 | 54.9 (49.9, 59.9) | 33.6 (29.6, 37.8) | 11.5 (8.4, 15.5) | 0.079 | |
| 20-39 | 73.0 (70.0, 75.9) | 27.0 (24.1, 30.0) | 57.3 (53.1, 61.4) | 31.5 (28.5, 34.8) | 11.2 (9.2, 13.6) | |||
| 40-59 | 76.1 (73.4, 78.5) | 23.9 (21.5, 26.6) | 61.2 (57.1, 65.1) | 29.8 (26.1, 33.7) | 9.0 (7.2, 11.4) | |||
| >=60 | 77.1 (75.3, 78.7) | 22.9 (21.3, 24.7) | 61.5 (58.9, 64.1) | 31.1 (28.3, 33.9) | 7.4 (5.9, 9.2) | |||
| Total | 74.5 (72.7, 76.2) | 25.5 (23.8, 27.3) | 58.9 (56.6, 61.1) | 31.2 (29.6, 32.9) | 9.9 (8.6, 11.4) | |||
| rs2243270 | A | G | AA | AG | GG | |||
| 12-19 | 71.4 (67.5, 75.0) | 28.6 (25.0, 32.5) | 0.016 | 54.3 (49.5, 59.0) | 34.3 (30.4, 38.4) | 11.4 (8.2, 15.7) | 0.100 | |
| 20-39 | 72.8 (69.5, 75.8) | 27.2 (24.2, 30.5) | 56.9 (52.4, 61.2) | 31.7 (28.7, 34.9) | 11.4 (9.3, 13.9) | |||
| 40-59 | 76.0 (73.3, 78.5) | 24.0 (21.5, 26.7) | 60.7 (56.2, 65.1) | 30.5 (26.2, 35.3) | 8.8 (6.9, 11.1) | |||
| >=60 | 76.8 (74.9, 78.6) | 23.2 (21.4, 25.1) | 60.7 (57.7, 63.6) | 32.2 (29.3, 35.3) | 7.1 (5.5, 8.9) | |||
| Total | 74.3 (72.4, 76.0) | 25.7 (24.0, 27.6) | 58.3 (55.9, 60.7) | 31.8 (30.1, 33.6) | 9.8 (8.4, 11.4) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs2243248 | G | T | GG | GT | TT | |||
| Male | 9.3 (8.3, 10.6) | 90.7 (89.4, 91.7) | 0.202 | 0.7 (0.4, 1.2) | 17.3 (15.1, 19.7) | 82.0 (79.6, 84.2) | 0.315 | |
| Female | 8.6 (7.6, 9.7) | 91.4 (90.3, 92.4) | 0.9 (0.5, 1.6) | 15.4 (13.8, 17.2) | 83.7 (81.7, 85.4) | |||
| Total | 9.0 (8.1, 9.9) | 91.0 (90.1, 91.9) | 0.8 (0.6, 1.1) | 16.3 (14.8, 18.0) | 82.9 (81.1, 84.5) | |||
| rs2243250 | C | T | CC | CT | TT | |||
| Male | 75.2 (72.9, 77.3) | 24.8 (22.7, 27.1) | 0.112 | 59.7 (56.3, 63.0) | 31.0 (28.5, 33.8) | 9.3 (7.9, 10.9) | 0.095 | |
| Female | 73.8 (72.2, 75.4) | 26.2 (24.6, 27.8) | 58.1 (55.7, 60.5) | 31.4 (29.0, 33.9) | 10.5 (9.0, 12.2) | |||
| Total | 74.5 (72.7, 76.2) | 25.5 (23.8, 27.3) | 58.9 (56.6, 61.1) | 31.2 (29.6, 32.9) | 9.9 (8.6, 11.4) | |||
| rs2243270 | A | G | AA | AG | GG | |||
| Male | 74.9 (72.6, 77.2) | 25.1 (22.8, 27.4) | 0.156 | 59.2 (55.6, 62.6) | 31.6 (28.8, 34.4) | 9.3 (7.9, 10.9) | 0.217 | |
| Female | 73.6 (71.9, 75.3) | 26.4 (24.7, 28.1) | 57.6 (55.2, 60.0) | 32.1 (29.8, 34.5) | 10.3 (8.7, 12.2) | |||
| Total | 74.3 (72.4, 76.0) | 25.7 (24.0, 27.6) | 58.3 (55.9, 60.7) | 31.8 (30.1, 33.6) | 9.8 (8.4, 11.4) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs2243248 | G | T | GG | GT | TT | ||
| Non-Hispanic White | 12-19 | 8.3 (5.9, 11.6) | 91.7 (88.4, 94.1) | 0.8 (0.1, 7.1) | 15.1 (12.1, 18.6) | 84.2 (79.5, 87.9) | |
| 20-39 | 7.5 (5.9, 9.4) | 92.5 (90.6, 94.1) | 0.3 (0.1, 0.7) | 14.4 (11.3, 18.1) | 85.3 (81.6, 88.4) | ||
| 40-59 | 8.6 (6.9, 10.7) | 91.4 (89.3, 93.1) | 0.5 (0.1, 2.1) | 16.2 (13.1, 19.9) | 83.3 (79.5, 86.5) | ||
| >=60 | 5.7 (4.7, 6.8) | 94.3 (93.2, 95.3) | 0.4 (0.1, 1.3) | 10.4 (8.7, 12.5) | 89.1 (87.0, 90.9) | ||
| Non-Hispanic Black | 12-19 | 16.1 (12.2, 21.1) | 83.9 (78.9, 87.8) | 2.7 (1.3, 5.3) | 26.9 (21.4, 33.2) | 70.4 (62.6, 77.2) | |
| 20-39 | 16.7 (15.4, 18.0) | 83.3 (82.0, 84.6) | 2.5 (1.7, 3.7) | 28.3 (26.0, 30.7) | 69.2 (66.9, 71.4) | ||
| 40-59 | 13.7 (11.1, 16.9) | 86.3 (83.1, 88.9) | 2.7 (1.1, 6.1) | 22.2 (18.0, 27.1) | 75.2 (70.2, 79.5) | ||
| >=60 | 16.0 (12.5, 20.1) | 84.0 (79.9, 87.5) | 1.7 (0.5, 5.1) | 28.6 (22.3, 35.9) | 69.7 (62.4, 76.2) | ||
| Mexican American | 12-19 | 10.4 (6.8, 15.5) | 89.6 (84.5, 93.2) | 1.8 (0.8, 3.9) | 17.1 (11.4, 24.8) | 81.1 (72.4, 87.5) | |
| 20-39 | 13.7 (10.8, 17.1) | 86.3 (82.9, 89.2) | 1.7 (0.7, 4.2) | 23.9 (20.0, 28.3) | 74.4 (69.0, 79.1) | ||
| 40-59 | 11.2 (8.5, 14.5) | 88.8 (85.5, 91.5) | 2.5 (1.0, 6.0) | 17.4 (14.2, 21.2) | 80.1 (75.4, 84.1) | ||
| >=60 | 8.4 (6.1, 11.5) | 91.6 (88.5, 93.9) | 1.6 (0.8, 3.3) | 13.7 (10.0, 18.3) | 84.7 (79.5, 88.8) | ||
| rs2243250 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 83.4 (79.5, 86.6) | 16.6 (13.4, 20.5) | 69.4 (62.4, 75.6) | 27.9 (21.7, 35.2) | 2.7 (1.2, 5.9) | |
| 20-39 | 84.3 (82.1, 86.3) | 15.7 (13.7, 17.9) | 72.1 (68.6, 75.4) | 24.4 (21.0, 28.1) | 3.5 (2.1, 5.8) | ||
| 40-59 | 84.2 (81.4, 86.6) | 15.8 (13.4, 18.6) | 70.5 (65.9, 74.7) | 27.4 (23.7, 31.5) | 2.1 (1.2, 3.9) | ||
| >=60 | 83.6 (81.3, 85.6) | 16.4 (14.4, 18.7) | 69.8 (65.8, 73.5) | 27.6 (24.2, 31.4) | 2.6 (1.7, 3.9) | ||
| Non-Hispanic Black | 12-19 | 38.2 (34.6, 42.0) | 61.8 (58.0, 65.4) | 16.7 (13.6, 20.4) | 43.0 (37.2, 49.1) | 40.2 (34.6, 46.1) | |
| 20-39 | 35.5 (32.9, 38.2) | 64.5 (61.8, 67.1) | 13.1 (10.6, 16.0) | 44.9 (40.4, 49.4) | 42.0 (38.0, 46.2) | ||
| 40-59 | 34.9 (31.7, 38.1) | 65.1 (61.9, 68.3) | 13.6 (10.4, 17.7) | 42.5 (37.8, 47.3) | 43.9 (39.7, 48.2) | ||
| >=60 | 36.8 (31.9, 42.0) | 63.2 (58.0, 68.1) | 14.7 (9.9, 21.2) | 44.2 (38.9, 49.7) | 41.1 (35.3, 47.1) | ||
| Mexican American | 12-19 | 60.0 (56.8, 63.2) | 40.0 (36.8, 43.2) | 36.5 (32.9, 40.3) | 47.1 (39.5, 54.8) | 16.4 (11.2, 23.5) | |
| 20-39 | 56.3 (52.5, 60.0) | 43.7 (40.0, 47.5) | 32.5 (26.3, 39.5) | 47.5 (41.3, 53.7) | 20.0 (18.2, 21.9) | ||
| 40-59 | 58.6 (54.1, 63.0) | 41.4 (37.0, 45.9) | 35.5 (28.8, 42.8) | 46.2 (37.3, 55.3) | 18.3 (13.3, 24.6) | ||
| >=60 | 58.5 (53.6, 63.3) | 41.5 (36.7, 46.4) | 36.3 (31.0, 42.0) | 44.5 (37.8, 51.3) | 19.2 (13.7, 26.4) | ||
| rs2243270 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 83.3 (79.6, 86.4) | 16.7 (13.6, 20.4) | 68.9 (61.8, 75.2) | 28.7 (22.0, 36.5) | 2.4 (1.0, 5.6) | |
| 20-39 | 83.9 (81.7, 85.8) | 16.1 (14.2, 18.3) | 71.1 (67.9, 74.1) | 25.5 (22.6, 28.6) | 3.4 (2.0, 5.7) | ||
| 40-59 | 83.9 (81.0, 86.4) | 16.1 (13.6, 19.0) | 69.8 (64.6, 74.5) | 28.1 (23.6, 33.2) | 2.0 (1.2, 3.5) | ||
| >=60 | 83.2 (80.6, 85.5) | 16.8 (14.5, 19.4) | 68.6 (64.3, 72.6) | 29.1 (25.5, 32.9) | 2.3 (1.3, 4.0) | ||
| Non-Hispanic Black | 12-19 | 36.9 (33.4, 40.7) | 63.1 (59.3, 66.6) | 14.8 (11.6, 18.8) | 44.3 (39.4, 49.2) | 40.9 (36.0, 46.1) | |
| 20-39 | 35.8 (32.8, 38.9) | 64.2 (61.1, 67.2) | 14.7 (12.7, 16.8) | 42.2 (38.4, 46.2) | 43.1 (38.5, 47.8) | ||
| 40-59 | 35.7 (32.7, 38.9) | 64.3 (61.1, 67.3) | 13.5 (10.8, 16.6) | 44.5 (37.2, 52.1) | 42.0 (35.9, 48.3) | ||
| >=60 | 38.2 (33.5, 43.1) | 61.8 (56.9, 66.5) | 15.8 (11.2, 21.8) | 44.8 (36.9, 53.0) | 39.4 (32.5, 46.8) | ||
| Mexican American | 12-19 | 60.5 (57.4, 63.5) | 39.5 (36.5, 42.6) | 37.1 (34.1, 40.2) | 46.8 (39.7, 54.0) | 16.1 (11.0, 22.9) | |
| 20-39 | 57.0 (53.1, 60.9) | 43.0 (39.1, 46.9) | 33.4 (27.3, 40.2) | 47.2 (41.6, 52.8) | 19.4 (17.5, 21.4) | ||
| 40-59 | 59.0 (54.3, 63.6) | 41.0 (36.4, 45.7) | 35.9 (29.1, 43.2) | 46.3 (38.1, 54.7) | 17.9 (13.2, 23.8) | ||
| >=60 | 58.1 (52.7, 63.3) | 41.9 (36.7, 47.3) | 36.6 (31.3, 42.3) | 43.1 (34.8, 51.8) | 20.4 (13.5, 29.4) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs2243248 | G | T | GG | GT | TT | ||
| Non-Hispanic White | Male | 8.5 (7.4, 9.7) | 91.5 (90.3, 92.6) | 0.5 (0.2, 1.3) | 16.0 (13.6, 18.7) | 83.5 (81.0, 85.8) | |
| Female | 6.6 (5.8, 7.5) | 93.4 (92.5, 94.2) | 0.4 (0.1, 1.4) | 12.3 (10.9, 14.0) | 87.2 (85.6, 88.7) | ||
| Non-Hispanic Black | Male | 15.8 (14.2, 17.6) | 84.2 (82.4, 85.8) | 2.5 (1.5, 4.1) | 26.7 (23.8, 29.8) | 70.8 (67.8, 73.7) | |
| Female | 15.7 (13.9, 17.7) | 84.3 (82.3, 86.1) | 2.5 (1.6, 3.9) | 26.4 (23.3, 29.7) | 71.1 (67.7, 74.3) | ||
| Mexican American | Male | 12.0 (10.2, 14.2) | 88.0 (85.8, 89.8) | 1.4 (0.9, 2.2) | 21.2 (18.2, 24.6) | 77.3 (73.6, 80.7) | |
| Female | 12.0 (9.4, 15.2) | 88.0 (84.8, 90.6) | 2.4 (1.4, 4.1) | 19.3 (15.6, 23.7) | 78.3 (73.1, 82.7) | ||
| rs2243250 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 84.4 (82.4, 86.1) | 15.6 (13.9, 17.6) | 71.4 (68.3, 74.4) | 25.8 (22.9, 29.0) | 2.7 (1.6, 4.7) | |
| Female | 83.7 (82.0, 85.2) | 16.3 (14.8, 18.0) | 70.2 (67.4, 72.8) | 27.0 (24.5, 29.6) | 2.9 (1.9, 4.2) | ||
| Non-Hispanic Black | Male | 35.2 (31.6, 38.9) | 64.8 (61.1, 68.4) | 13.4 (10.4, 16.9) | 43.6 (39.7, 47.6) | 43.0 (38.3, 47.9) | |
| Female | 36.8 (34.3, 39.3) | 63.2 (60.7, 65.7) | 14.8 (12.5, 17.3) | 44.0 (40.3, 47.8) | 41.2 (37.5, 45.0) | ||
| Mexican American | Male | 57.1 (54.2, 60.0) | 42.9 (40.0, 45.8) | 32.6 (27.4, 38.2) | 49.0 (43.1, 54.9) | 18.4 (16.2, 20.9) | |
| Female | 58.4 (56.7, 60.1) | 41.6 (39.9, 43.3) | 36.1 (33.9, 38.3) | 44.6 (42.1, 47.2) | 19.3 (17.4, 21.4) | ||
| rs2243270 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 84.0 (82.1, 85.9) | 16.0 (14.1, 17.9) | 70.8 (67.5, 73.8) | 26.5 (23.4, 29.9) | 2.7 (1.5, 4.8) | |
| Female | 83.2 (81.7, 84.7) | 16.8 (15.3, 18.3) | 69.1 (66.5, 71.6) | 28.3 (25.9, 30.8) | 2.6 (1.8, 3.8) | ||
| Non-Hispanic Black | Male | 35.0 (32.0, 38.1) | 65.0 (61.9, 68.0) | 13.4 (11.1, 16.0) | 43.3 (39.0, 47.7) | 43.3 (38.7, 48.1) | |
| Female | 37.4 (35.2, 39.6) | 62.6 (60.4, 64.8) | 15.5 (13.6, 17.7) | 43.7 (40.4, 47.1) | 40.8 (37.5, 44.1) | ||
| Mexican American | Male | 57.7 (54.3, 61.1) | 42.3 (38.9, 45.7) | 33.5 (28.5, 38.9) | 48.5 (43.7, 53.3) | 18.0 (15.5, 20.9) | |
| Female | 58.8 (56.7, 60.8) | 41.2 (39.2, 43.3) | 36.5 (34.1, 39.0) | 44.6 (41.9, 47.2) | 18.9 (16.6, 21.5) | ||
- Page last reviewed: March 16, 2009 (archived document)
- Content source: