FCGR2A Allele and Genotype Frequencies
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Available polymorphism(s)
|
rs number |
Common Designations Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs1801274 |
Ex4-120A>G |
His166Arg |
TaqMan |
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs1801274 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 49.4 (47.6, 51.1) | 50.6 (48.9, 52.4) | 0.096 | 24.9 (23.0, 26.9) | 48.9 (46.8, 51.1) | 26.2 (24.1, 28.4) | 0.127 | 0.06 | |
| Non-Hispanic Black | 47.4 (45.8, 49.0) | 52.6 (51.0, 54.2) | 21.8 (20.2, 23.5) | 51.3 (49.5, 53.1) | 26.9 (25.0, 29.0) | 0.32 | |||
| Mexican American | 48.6 (47.1, 50.1) | 51.4 (49.9, 52.9) | 23.7 (22.1, 25.4) | 49.8 (47.1, 52.5) | 26.5 (24.3, 28.8) | 0.50 | |||
| Total* | 50.0 (48.5, 51.6) | 50.0 (48.4, 51.5) | 25.6 (23.9, 27.3) | 48.9 (47.4, 50.5) | 25.5 (23.8, 27.2) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1801274 | A | G | AA | AG | GG | |||
| 12-19 | 52.3 (48.3, 56.4) | 47.7 (43.6, 51.7) | 0.161 | 26.6 (22.2, 31.6) | 51.4 (47.4, 55.3) | 22.0 (18.0, 26.6) | 0.014 | |
| 20-39 | 48.6 (46.6, 50.6) | 51.4 (49.4, 53.4) | 24.0 (22.0, 26.2) | 49.2 (45.7, 52.6) | 26.8 (23.9, 30.0) | |||
| 40-59 | 51.5 (48.5, 54.5) | 48.5 (45.5, 51.5) | 26.5 (23.0, 30.3) | 50.0 (45.8, 54.2) | 23.5 (20.1, 27.4) | |||
| >=60 | 49.2 (46.8, 51.7) | 50.8 (48.3, 53.2) | 26.7 (24.4, 29.1) | 45.1 (42.5, 47.8) | 28.2 (25.1, 31.5) | |||
| Total | 50.0 (48.5, 51.6) | 50.0 (48.4, 51.5) | 25.6 (23.9, 27.3) | 48.9 (47.4, 50.5) | 25.5 (23.8, 27.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1801274 | A | G | AA | AG | GG | |||
| Male | 49.0 (46.4, 51.6) | 51.0 (48.4, 53.6) | 0.248 | 25.1 (22.4, 28.0) | 47.9 (45.0, 50.9) | 27.0 (24.0, 30.3) | 0.395 | |
| Female | 51.0 (48.9, 53.0) | 49.0 (47.0, 51.1) | 26.1 (23.7, 28.5) | 49.8 (47.7, 52.0) | 24.1 (22.0, 26.4) | |||
| Total | 50.0 (48.5, 51.6) | 50.0 (48.4, 51.5) | 25.6 (23.9, 27.3) | 48.9 (47.4, 50.5) | 25.5 (23.8, 27.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1801274 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 52.4 (46.9, 57.9) | 47.6 (42.1, 53.1) | 26.4 (20.4, 33.4) | 52.1 (46.4, 57.8) | 21.5 (16.2, 27.9) | |
| 20-39 | 47.6 (45.0, 50.1) | 52.4 (49.9, 55.0) | 23.3 (20.8, 26.1) | 48.4 (43.6, 53.3) | 28.2 (24.2, 32.6) | ||
| 40-59 | 51.4 (48.0, 54.8) | 48.6 (45.2, 52.0) | 25.8 (22.0, 29.8) | 51.3 (46.9, 55.7) | 22.9 (18.9, 27.5) | ||
| >=60 | 48.1 (44.9, 51.2) | 51.9 (48.8, 55.1) | 25.7 (22.8, 28.8) | 44.8 (41.8, 47.8) | 29.6 (25.8, 33.6) | ||
| Non-Hispanic Black | 12-19 | 50.2 (46.0, 54.5) | 49.8 (45.5, 54.0) | 25.1 (20.0, 30.9) | 50.3 (45.5, 55.2) | 24.6 (20.5, 29.2) | |
| 20-39 | 46.9 (44.1, 49.6) | 53.1 (50.4, 55.9) | 20.1 (17.5, 23.0) | 53.5 (49.0, 57.9) | 26.4 (22.4, 30.8) | ||
| 40-59 | 45.8 (42.5, 49.0) | 54.2 (51.0, 57.5) | 21.5 (18.5, 25.0) | 48.4 (42.8, 54.1) | 30.0 (25.1, 35.4) | ||
| >=60 | 48.4 (43.5, 53.4) | 51.6 (46.6, 56.5) | 22.9 (18.0, 28.7) | 51.0 (46.2, 55.7) | 26.1 (20.8, 32.1) | ||
| Mexican American | 12-19 | 53.3 (51.0, 55.7) | 46.7 (44.3, 49.0) | 29.8 (27.0, 32.7) | 47.1 (42.8, 51.5) | 23.1 (19.7, 26.9) | |
| 20-39 | 47.6 (45.9, 49.4) | 52.4 (50.6, 54.1) | 23.1 (20.3, 26.1) | 49.1 (44.6, 53.5) | 27.9 (25.2, 30.7) | ||
| 40-59 | 47.5 (43.5, 51.6) | 52.5 (48.4, 56.5) | 21.9 (17.1, 27.5) | 51.3 (45.8, 56.9) | 26.8 (22.5, 31.6) | ||
| >=60 | 45.8 (39.8, 51.9) | 54.2 (48.1, 60.2) | 17.6 (13.2, 23.0) | 56.5 (50.0, 62.8) | 26.0 (18.5, 35.2) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1801274 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 48.1 (44.9, 51.3) | 51.9 (48.7, 55.1) | 24.1 (20.7, 27.8) | 47.9 (44.4, 51.5) | 28.0 (24.3, 32.0) | |
| Female | 50.6 (48.5, 52.8) | 49.4 (47.2, 51.5) | 25.7 (23.3, 28.3) | 49.8 (47.1, 52.6) | 24.5 (21.9, 27.2) | ||
| Non-Hispanic Black | Male | 46.8 (44.4, 49.2) | 53.2 (50.8, 55.6) | 21.6 (19.3, 24.1) | 50.3 (47.1, 53.6) | 28.0 (24.8, 31.5) | |
| Female | 48.0 (45.9, 50.0) | 52.0 (50.0, 54.1) | 21.9 (19.2, 24.8) | 52.1 (49.2, 55.0) | 26.0 (23.8, 28.3) | ||
| Mexican American | Male | 48.9 (46.7, 51.1) | 51.1 (48.9, 53.3) | 24.0 (21.5, 26.7) | 49.8 (45.8, 53.7) | 26.2 (23.1, 29.6) | |
| Female | 48.3 (45.6, 51.0) | 51.7 (49.0, 54.4) | 23.4 (21.0, 25.9) | 49.8 (46.5, 53.1) | 26.8 (23.2, 30.7) | ||
- Page last reviewed: March 16, 2009 (archived document)
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