CYP2C9 Allele and Genotype Frequencies

Available polymorphism(s)

	Common Designations
rs number	Nucleotide change	Amino acid change	Genotyping method
rs1057910	Ex7-75A>C	Ile359Leu	TaqMan

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By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs1057910		A	C		AA	AC	CC
	Non-Hispanic White	93.2 (92.4, 94.0)	6.8 (6.0, 7.6)	<0.001	87.1 (85.4, 88.5)	12.3 (10.9, 14.0)	0.6 (0.4, 0.9)	<0.001	0.28
	Non-Hispanic Black	98.9 (98.2, 99.4)	1.1 (0.6, 1.8)		97.9 (96.5, 98.7)	2.0 (1.2, 3.4)	0.0 (0.0, 0.3)		0.08
	Mexican American	96.1 (95.1, 96.9)	3.9 (3.1, 4.9)		92.4 (90.4, 93.9)	7.5 (6.0, 9.4)	0.1 (0.0, 0.4)		0.58
	Total*	94.2 (93.6, 94.8)	5.8 (5.2, 6.4)		89.0 (87.9, 90.1)	10.4 (9.4, 11.5)	0.6 (0.4, 0.9)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1057910		A	C		AA	AC	CC
	12-19	94.7 (92.3, 96.4)	5.3 (3.6, 7.7)	0.282	90.1 (86.1, 93.1)	9.1 (6.5, 12.7)	0.7 (0.2, 3.0)	0.326
	20-39	94.9 (93.7, 95.9)	5.1 (4.1, 6.3)		90.6 (88.1, 92.6)	8.6 (6.4, 11.4)	0.8 (0.5, 1.4)
	40-59	93.7 (92.0, 95.1)	6.3 (4.9, 8.0)		87.7 (84.3, 90.5)	12.0 (9.2, 15.5)	0.3 (0.1, 1.0)
	>=60	93.2 (92.1, 94.2)	6.8 (5.8, 7.9)		86.9 (85.0, 88.7)	12.6 (11.0, 14.4)	0.5 (0.1, 1.5)
	Total	94.2 (93.6, 94.8)	5.8 (5.2, 6.4)		89.0 (87.9, 90.1)	10.4 (9.4, 11.5)	0.6 (0.4, 0.9)

* Includes all participants, regardless of race/ethnicity.

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By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1057910		A	C		AA	AC	CC
	Male	94.5 (93.3, 95.5)	5.5 (4.5, 6.7)	0.390	89.5 (87.3, 91.4)	10.0 (8.3, 12.1)	0.5 (0.2, 0.9)	0.404
	Female	93.9 (93.1, 94.6)	6.1 (5.4, 6.9)		88.6 (87.0, 90.0)	10.7 (9.3, 12.3)	0.7 (0.4, 1.2)
	Total	94.2 (93.6, 94.8)	5.8 (5.2, 6.4)		89.0 (87.9, 90.1)	10.4 (9.4, 11.5)	0.6 (0.4, 0.9)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs1057910			A	C	AA	AC	CC
	Non-Hispanic White	12-19	93.6 (90.7, 95.7)	6.4 (4.3, 9.3)	87.7 (81.9, 91.7)	12.0 (7.9, 17.7)	0.4 (0.1, 1.6)
		20-39	93.8 (92.0, 95.2)	6.2 (4.8, 8.0)	88.5 (84.8, 91.5)	10.5 (7.6, 14.5)	0.9 (0.6, 1.3)
		40-59	92.8 (90.5, 94.6)	7.2 (5.4, 9.5)	86.0 (81.5, 89.6)	13.6 (10.0, 18.2)	0.4 (0.1, 1.3)
		>=60	92.6 (91.2, 93.7)	7.4 (6.3, 8.8)	85.6 (83.4, 87.6)	13.9 (12.1, 15.8)	0.5 (0.1, 1.9)
	Non-Hispanic Black	12-19	98.6 (97.1, 99.4)	1.4 (0.6, 2.9)	97.2 (94.2, 98.7)	2.8 (1.3, 5.8)	0.0 (NA)
		20-39	98.8 (97.7, 99.4)	1.2 (0.6, 2.3)	97.6 (95.4, 98.8)	2.4 (1.2, 4.6)	0.0 (NA)
		40-59	99.1 (97.8, 99.7)	0.9 (0.3, 2.2)	98.5 (95.9, 99.4)	1.4 (0.5, 4.1)	0.2 (0.0, 1.2)
		>=60	99.3 (98.0, 99.8)	0.7 (0.2, 2.0)	98.6 (96.0, 99.5)	1.4 (0.5, 4.0)	0.0 (NA)
	Mexican American	12-19	96.4 (93.8, 98.0)	3.6 (2.0, 6.2)	93.3 (88.4, 96.2)	6.2 (3.3, 11.3)	0.5 (0.1, 3.7)
		20-39	96.1 (94.9, 97.1)	3.9 (2.9, 5.1)	92.2 (89.8, 94.2)	7.8 (5.8, 10.2)	0.0 (NA)
		40-59	95.4 (93.4, 96.8)	4.6 (3.2, 6.6)	90.9 (86.8, 93.8)	9.0 (6.0, 13.3)	0.1 (0.0, 0.9)
		>=60	97.2 (95.1, 98.4)	2.8 (1.6, 4.9)	94.4 (90.3, 96.9)	5.6 (3.1, 9.7)	0.0 (NA)

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By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs1057910			A	C	AA	AC	CC
	Non-Hispanic White	Male	93.8 (92.2, 95.0)	6.2 (5.0, 7.8)	88.0 (85.2, 90.3)	11.6 (9.4, 14.2)	0.4 (0.2, 1.1)
		Female	92.7 (91.8, 93.5)	7.3 (6.5, 8.2)	86.2 (84.3, 87.8)	13.0 (11.2, 15.1)	0.8 (0.5, 1.2)
	Non-Hispanic Black	Male	98.7 (97.7, 99.2)	1.3 (0.8, 2.3)	97.3 (95.4, 98.5)	2.7 (1.5, 4.6)	0.0 (NA)
		Female	99.2 (98.6, 99.5)	0.8 (0.5, 1.4)	98.4 (97.3, 99.1)	1.5 (0.9, 2.6)	0.1 (0.0, 0.6)
	Mexican American	Male	95.7 (94.1, 96.9)	4.3 (3.1, 5.9)	91.7 (88.8, 93.9)	8.1 (6.1, 10.8)	0.2 (0.1, 0.7)
		Female	96.5 (95.4, 97.4)	3.5 (2.6, 4.6)	93.1 (90.8, 94.8)	6.9 (5.2, 9.2)	0.0 (NA)

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