CYP1B1 Allele and Genotype Frequencies
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Available polymorphism(s)
| Common Designations | |||
|---|---|---|---|
|
rs number |
Nucleotide change | Amino acid change |
Genotyping method |
| rs1056836 | Ex3+251G>C | Val432Leu | TaqMan |
| rs1056837 | Ex3+304T>C | Asp449Asp | TaqMan |
| rs162557 | -2919C>T | TaqMan | |
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs1056836 | C | G | CC | CG | GG | ||||
| Non-Hispanic White | 54.8 (53.2, 56.4) | 45.2 (43.6, 46.8) | <0.001 | 30.7 (29.1, 32.4) | 48.2 (45.2, 51.1) | 21.1 (18.7, 23.8) | <0.001 | 0.42 | |
| Non-Hispanic Black | 25.0 (23.5, 26.5) | 75.0 (73.5, 76.5) | 5.9 (4.8, 7.3) | 38.2 (35.8, 40.7) | 55.9 (53.5, 58.3) | 0.14 | |||
| Mexican American | 73.5 (71.1, 75.7) | 26.5 (24.3, 28.9) | 55.3 (52.0, 58.4) | 36.4 (34.2, 38.7) | 8.3 (6.9, 10.1) | 0.02 | |||
| Total* | 54.0 (52.2, 55.9) | 46.0 (44.1, 47.8) | 31.3 (29.6, 33.0) | 45.5 (43.1, 47.9) | 23.2 (20.7, 26.0) | ||||
| rs1056837 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 55.0 (53.3, 56.7) | 45.0 (43.3, 46.7) | <0.001 | 31.0 (29.2, 32.9) | 47.9 (44.9, 50.9) | 21.0 (18.5, 23.7) | <0.001 | 0.21 | |
| Non-Hispanic Black | 27.3 (25.7, 29.0) | 72.7 (71.0, 74.3) | 7.2 (6.0, 8.8) | 40.1 (37.1, 43.1) | 52.6 (49.8, 55.5) | 0.52 | |||
| Mexican American | 73.7 (71.2, 76.0) | 26.3 (24.0, 28.8) | 55.9 (52.8, 59.0) | 35.5 (33.7, 37.4) | 8.6 (6.7, 10.8) | 0.01 | |||
| Total* | 54.5 (52.7, 56.3) | 45.5 (43.7, 47.3) | 31.7 (30.0, 33.5) | 45.5 (43.1, 48.0) | 22.7 (20.3, 25.4) | ||||
| rs162557 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 76.8 (74.8, 78.7) | 23.2 (21.3, 25.2) | <0.001 | 59.2 (56.5, 61.7) | 35.2 (33.4, 37.0) | 5.6 (4.2, 7.4) | <0.001 | 0.81 | |
| Non-Hispanic Black | 78.4 (76.6, 80.0) | 21.6 (20.0, 23.4) | 61.2 (58.1, 64.2) | 34.2 (31.2, 37.5) | 4.5 (3.5, 5.9) | 0.64 | |||
| Mexican American | 86.9 (85.3, 88.4) | 13.1 (11.6, 14.7) | 75.6 (72.6, 78.4) | 22.6 (20.0, 25.5) | 1.7 (1.2, 2.5) | 0.99 | |||
| Total* | 78.6 (76.9, 80.2) | 21.4 (19.8, 23.1) | 62.1 (59.7, 64.4) | 33.1 (31.3, 34.9) | 4.8 (3.7, 6.3) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1056836 | C | G | CC | CG | GG | |||
| 12-19 | 50.6 (45.6, 55.6) | 49.4 (44.4, 54.4) | 0.224 | 26.9 (22.4, 32.1) | 47.3 (41.8, 52.8) | 25.8 (19.9, 32.7) | 0.312 | |
| 20-39 | 54.9 (52.3, 57.5) | 45.1 (42.5, 47.7) | 32.6 (29.5, 35.8) | 44.7 (41.4, 48.1) | 22.7 (19.9, 25.8) | |||
| 40-59 | 53.1 (49.3, 56.8) | 46.9 (43.2, 50.7) | 30.2 (26.3, 34.3) | 45.8 (42.6, 48.9) | 24.1 (20.1, 28.5) | |||
| >=60 | 56.1 (52.7, 59.3) | 43.9 (40.7, 47.3) | 33.3 (29.5, 37.3) | 45.5 (41.8, 49.2) | 21.2 (17.8, 25.1) | |||
| Total | 54.0 (52.2, 55.9) | 46.0 (44.1, 47.8) | 31.3 (29.6, 33.0) | 45.5 (43.1, 47.9) | 23.2 (20.7, 26.0) | |||
| rs1056837 | C | T | CC | CT | TT | |||
| 12-19 | 50.9 (46.1, 55.7) | 49.1 (44.3, 53.9) | 0.133 | 27.2 (22.7, 32.3) | 47.3 (42.0, 52.7) | 25.5 (19.8, 32.1) | 0.245 | |
| 20-39 | 55.2 (52.8, 57.6) | 44.8 (42.4, 47.2) | 32.8 (29.8, 36.0) | 44.8 (41.3, 48.3) | 22.4 (19.7, 25.4) | |||
| 40-59 | 53.4 (49.6, 57.2) | 46.6 (42.8, 50.4) | 30.4 (26.6, 34.5) | 46.0 (43.0, 49.0) | 23.6 (19.7, 28.1) | |||
| >=60 | 57.3 (54.1, 60.4) | 42.7 (39.6, 45.9) | 34.7 (30.9, 38.7) | 45.1 (41.0, 49.4) | 20.2 (16.8, 24.1) | |||
| Total | 54.5 (52.7, 56.3) | 45.5 (43.7, 47.3) | 31.7 (30.0, 33.5) | 45.5 (43.1, 48.0) | 22.7 (20.3, 25.4) | |||
| rs162557 | C | T | CC | CT | TT | |||
| 12-19 | 80.7 (78.2, 83.0) | 19.3 (17.0, 21.8) | 0.096 | 64.3 (59.7, 68.6) | 32.8 (28.2, 37.7) | 2.9 (1.6, 5.3) | 0.023 | |
| 20-39 | 79.4 (77.8, 80.9) | 20.6 (19.1, 22.2) | 63.8 (61.0, 66.5) | 31.2 (27.7, 34.9) | 5.0 (3.3, 7.5) | |||
| 40-59 | 77.4 (73.7, 80.8) | 22.6 (19.2, 26.3) | 60.3 (54.5, 65.8) | 34.3 (29.7, 39.2) | 5.4 (3.7, 7.9) | |||
| >=60 | 77.3 (75.4, 79.1) | 22.7 (20.9, 24.6) | 59.6 (56.5, 62.6) | 35.4 (32.4, 38.5) | 5.0 (3.7, 6.7) | |||
| Total | 78.6 (76.9, 80.2) | 21.4 (19.8, 23.1) | 62.1 (59.7, 64.4) | 33.1 (31.3, 34.9) | 4.8 (3.7, 6.3) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1056836 | C | G | CC | CG | GG | |||
| Male | 54.8 (51.4, 58.1) | 45.2 (41.9, 48.6) | 0.398 | 32.4 (29.1, 35.8) | 44.9 (42.0, 47.9) | 22.7 (19.0, 26.9) | 0.660 | |
| Female | 53.3 (51.6, 55.0) | 46.7 (45.0, 48.4) | 30.3 (28.1, 32.6) | 46.0 (42.9, 49.2) | 23.7 (21.4, 26.1) | |||
| Total | 54.0 (52.2, 55.9) | 46.0 (44.1, 47.8) | 31.3 (29.6, 33.0) | 45.5 (43.1, 47.9) | 23.2 (20.7, 26.0) | |||
| rs1056837 | C | T | CC | CT | TT | |||
| Male | 55.2 (52.2, 58.2) | 44.8 (41.8, 47.8) | 0.358 | 32.4 (29.5, 35.4) | 45.7 (42.7, 48.8) | 21.9 (18.4, 25.8) | 0.615 | |
| Female | 53.8 (52.0, 55.6) | 46.2 (44.4, 48.0) | 31.1 (28.8, 33.5) | 45.4 (42.4, 48.4) | 23.5 (21.3, 25.9) | |||
| Total | 54.5 (52.7, 56.3) | 45.5 (43.7, 47.3) | 31.7 (30.0, 33.5) | 45.5 (43.1, 48.0) | 22.7 (20.3, 25.4) | |||
| rs162557 | C | T | CC | CT | TT | |||
| Male | 79.3 (77.1, 81.3) | 20.7 (18.7, 22.9) | 0.261 | 63.5 (60.3, 66.6) | 31.7 (29.0, 34.5) | 4.8 (3.4, 6.8) | 0.384 | |
| Female | 78.0 (75.8, 80.0) | 22.0 (20.0, 24.2) | 60.8 (57.7, 63.8) | 34.4 (31.7, 37.2) | 4.8 (3.3, 7.0) | |||
| Total | 78.6 (76.9, 80.2) | 21.4 (19.8, 23.1) | 62.1 (59.7, 64.4) | 33.1 (31.3, 34.9) | 4.8 (3.7, 6.3) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1056836 | C | G | CC | CG | GG | ||
| Non-Hispanic White | 12-19 | 51.4 (45.0, 57.8) | 48.6 (42.2, 55.0) | 27.1 (21.5, 33.6) | 48.6 (41.9, 55.3) | 24.3 (17.0, 33.4) | |
| 20-39 | 55.5 (52.1, 58.9) | 44.5 (41.1, 47.9) | 31.4 (27.4, 35.7) | 48.2 (44.1, 52.3) | 20.4 (16.9, 24.3) | ||
| 40-59 | 53.2 (49.1, 57.3) | 46.8 (42.7, 50.9) | 29.1 (24.7, 33.8) | 48.3 (44.3, 52.4) | 22.6 (18.3, 27.5) | ||
| >=60 | 57.5 (54.4, 60.7) | 42.5 (39.3, 45.6) | 33.7 (29.7, 38.0) | 47.6 (42.8, 52.5) | 18.6 (15.1, 22.7) | ||
| Non-Hispanic Black | 12-19 | 26.3 (23.0, 29.8) | 73.7 (70.2, 77.0) | 6.2 (3.7, 10.1) | 40.2 (34.6, 46.1) | 53.6 (48.1, 59.1) | |
| 20-39 | 25.1 (22.7, 27.7) | 74.9 (72.3, 77.3) | 6.6 (4.8, 9.1) | 37.1 (32.5, 41.8) | 56.4 (51.9, 60.7) | ||
| 40-59 | 24.0 (21.3, 26.9) | 76.0 (73.1, 78.7) | 5.2 (3.4, 7.9) | 37.5 (33.9, 41.1) | 57.3 (53.0, 61.4) | ||
| >=60 | 24.8 (20.7, 29.5) | 75.2 (70.5, 79.3) | 4.7 (2.4, 9.2) | 40.2 (34.8, 46.0) | 55.0 (48.3, 61.6) | ||
| Mexican American | 12-19 | 73.1 (69.9, 76.1) | 26.9 (23.9, 30.1) | 56.2 (51.4, 60.9) | 33.9 (29.1, 39.0) | 9.9 (7.3, 13.3) | |
| 20-39 | 72.8 (69.8, 75.6) | 27.2 (24.4, 30.2) | 54.4 (50.5, 58.3) | 36.9 (34.2, 39.6) | 8.7 (6.7, 11.4) | ||
| 40-59 | 74.1 (70.7, 77.2) | 25.9 (22.8, 29.3) | 55.2 (49.6, 60.6) | 37.9 (32.4, 43.6) | 7.0 (4.8, 10.0) | ||
| >=60 | 76.4 (72.3, 80.1) | 23.6 (19.9, 27.7) | 58.4 (53.0, 63.6) | 36.0 (30.7, 41.8) | 5.6 (2.6, 11.6) | ||
| rs1056837 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 51.0 (44.6, 57.4) | 49.0 (42.6, 55.4) | 27.0 (21.2, 33.7) | 48.0 (41.9, 54.2) | 25.0 (18.0, 33.7) | |
| 20-39 | 55.6 (52.5, 58.7) | 44.4 (41.3, 47.5) | 31.5 (27.7, 35.6) | 48.2 (44.0, 52.3) | 20.3 (17.1, 24.0) | ||
| 40-59 | 53.3 (49.2, 57.2) | 46.7 (42.8, 50.8) | 29.1 (24.9, 33.6) | 48.3 (44.5, 52.2) | 22.6 (18.3, 27.4) | ||
| >=60 | 58.6 (55.4, 61.6) | 41.4 (38.4, 44.6) | 35.1 (30.9, 39.5) | 47.0 (42.0, 52.1) | 17.9 (14.5, 21.9) | ||
| Non-Hispanic Black | 12-19 | 29.5 (26.5, 32.7) | 70.5 (67.3, 73.5) | 7.8 (5.2, 11.4) | 43.5 (39.3, 47.8) | 48.7 (44.3, 53.2) | |
| 20-39 | 26.6 (23.9, 29.6) | 73.4 (70.4, 76.1) | 7.6 (5.5, 10.4) | 38.1 (32.7, 43.8) | 54.3 (49.2, 59.3) | ||
| 40-59 | 26.9 (23.5, 30.5) | 73.1 (69.5, 76.5) | 6.9 (4.8, 10.0) | 39.8 (35.1, 44.8) | 53.2 (47.8, 58.6) | ||
| >=60 | 27.2 (23.1, 31.7) | 72.8 (68.3, 76.9) | 6.0 (3.4, 10.4) | 42.3 (38.1, 46.6) | 51.6 (45.7, 57.5) | ||
| Mexican American | 12-19 | 73.5 (70.5, 76.4) | 26.5 (23.6, 29.5) | 57.5 (53.2, 61.8) | 32.0 (27.4, 37.1) | 10.4 (7.6, 14.2) | |
| 20-39 | 73.1 (69.7, 76.3) | 26.9 (23.7, 30.3) | 54.8 (50.6, 58.8) | 36.7 (34.2, 39.2) | 8.6 (6.1, 11.9) | ||
| 40-59 | 74.0 (70.6, 77.1) | 26.0 (22.9, 29.4) | 56.0 (50.5, 61.3) | 36.0 (30.7, 41.6) | 8.1 (5.8, 11.1) | ||
| >=60 | 76.8 (73.0, 80.2) | 23.2 (19.8, 27.0) | 58.9 (53.5, 64.1) | 35.8 (30.2, 41.7) | 5.3 (2.6, 10.6) | ||
| rs162557 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 79.3 (76.0, 82.2) | 20.7 (17.8, 24.0) | 61.6 (55.8, 67.2) | 35.3 (29.4, 41.7) | 3.1 (1.4, 6.4) | |
| 20-39 | 77.3 (75.2, 79.2) | 22.7 (20.8, 24.8) | 60.6 (56.9, 64.1) | 33.4 (28.7, 38.4) | 6.0 (3.9, 9.1) | ||
| 40-59 | 75.3 (70.8, 79.3) | 24.7 (20.7, 29.2) | 57.0 (50.3, 63.5) | 36.6 (31.2, 42.3) | 6.4 (4.2, 9.7) | ||
| >=60 | 76.5 (74.4, 78.5) | 23.5 (21.5, 25.6) | 58.3 (54.9, 61.6) | 36.5 (33.2, 40.0) | 5.2 (3.7, 7.3) | ||
| Non-Hispanic Black | 12-19 | 79.7 (76.0, 83.0) | 20.3 (17.0, 24.0) | 63.8 (57.7, 69.5) | 31.8 (26.1, 38.1) | 4.3 (2.3, 7.9) | |
| 20-39 | 77.7 (74.8, 80.4) | 22.3 (19.6, 25.2) | 61.0 (56.2, 65.7) | 33.3 (28.6, 38.4) | 5.6 (3.8, 8.3) | ||
| 40-59 | 78.9 (76.6, 81.0) | 21.1 (19.0, 23.4) | 61.5 (57.3, 65.6) | 34.8 (30.4, 39.5) | 3.7 (2.3, 5.8) | ||
| >=60 | 77.5 (74.5, 80.3) | 22.5 (19.7, 25.5) | 57.9 (52.8, 62.9) | 39.2 (34.4, 44.3) | 2.9 (1.5, 5.3) | ||
| Mexican American | 12-19 | 84.3 (81.2, 87.1) | 15.7 (12.9, 18.8) | 71.4 (66.2, 76.1) | 25.9 (21.5, 30.9) | 2.7 (1.3, 5.5) | |
| 20-39 | 87.7 (85.9, 89.4) | 12.3 (10.6, 14.1) | 76.8 (73.0, 80.2) | 21.8 (18.2, 26.0) | 1.3 (0.8, 2.2) | ||
| 40-59 | 86.3 (83.4, 88.9) | 13.7 (11.1, 16.6) | 74.8 (69.9, 79.2) | 23.1 (19.0, 27.7) | 2.1 (1.0, 4.5) | ||
| >=60 | 90.0 (87.6, 92.0) | 10.0 (8.0, 12.4) | 80.8 (75.7, 85.1) | 18.4 (13.7, 24.1) | 0.8 (0.2, 2.9) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1056836 | C | G | CC | CG | GG | ||
| Non-Hispanic White | Male | 55.3 (51.5, 59.0) | 44.7 (41.0, 48.5) | 31.6 (27.6, 35.8) | 47.3 (43.8, 50.9) | 21.1 (17.2, 25.6) | |
| Female | 54.4 (51.9, 56.8) | 45.6 (43.2, 48.1) | 29.9 (26.9, 33.1) | 48.9 (45.2, 52.7) | 21.2 (18.2, 24.4) | ||
| Non-Hispanic Black | Male | 24.8 (22.3, 27.4) | 75.2 (72.6, 77.7) | 5.2 (3.8, 7.2) | 39.1 (35.5, 42.8) | 55.7 (51.6, 59.7) | |
| Female | 25.2 (22.9, 27.7) | 74.8 (72.3, 77.1) | 6.5 (4.6, 9.1) | 37.4 (34.3, 40.7) | 56.1 (52.6, 59.5) | ||
| Mexican American | Male | 73.9 (70.9, 76.7) | 26.1 (23.3, 29.1) | 55.9 (51.5, 60.2) | 36.0 (32.0, 40.2) | 8.1 (6.0, 10.9) | |
| Female | 73.0 (69.9, 75.9) | 27.0 (24.1, 30.1) | 54.6 (49.5, 59.5) | 36.9 (32.5, 41.5) | 8.6 (6.9, 10.6) | ||
| rs1056837 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 55.4 (52.2, 58.6) | 44.6 (41.4, 47.8) | 31.5 (28.1, 35.1) | 47.9 (44.3, 51.5) | 20.6 (17.1, 24.7) | |
| Female | 54.6 (52.0, 57.3) | 45.4 (42.7, 48.0) | 30.6 (27.5, 33.9) | 48.0 (44.5, 51.5) | 21.4 (18.4, 24.7) | ||
| Non-Hispanic Black | Male | 27.2 (24.5, 30.0) | 72.8 (70.0, 75.5) | 5.9 (4.2, 8.1) | 42.6 (38.7, 46.5) | 51.6 (47.2, 55.9) | |
| Female | 27.4 (25.1, 29.8) | 72.6 (70.2, 74.9) | 8.4 (6.4, 10.9) | 38.1 (35.0, 41.2) | 53.6 (50.2, 56.8) | ||
| Mexican American | Male | 74.1 (70.9, 77.1) | 25.9 (22.9, 29.1) | 56.1 (51.6, 60.5) | 36.0 (32.2, 40.0) | 7.9 (5.7, 10.9) | |
| Female | 73.3 (70.0, 76.2) | 26.7 (23.8, 30.0) | 55.8 (51.1, 60.4) | 34.9 (30.5, 39.6) | 9.3 (6.9, 12.4) | ||
| rs162557 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 77.8 (74.9, 80.4) | 22.2 (19.6, 25.1) | 61.2 (57.2, 65.1) | 33.1 (29.9, 36.4) | 5.7 (3.8, 8.4) | |
| Female | 75.8 (73.4, 78.1) | 24.2 (21.9, 26.6) | 57.2 (54.0, 60.4) | 37.2 (34.3, 40.3) | 5.5 (3.6, 8.3) | ||
| Non-Hispanic Black | Male | 78.7 (76.4, 80.9) | 21.3 (19.1, 23.6) | 61.1 (57.5, 64.6) | 35.2 (32.1, 38.4) | 3.7 (2.4, 5.5) | |
| Female | 78.1 (75.3, 80.6) | 21.9 (19.4, 24.7) | 61.3 (56.8, 65.6) | 33.4 (29.5, 37.7) | 5.2 (3.8, 7.2) | ||
| Mexican American | Male | 87.5 (85.2, 89.4) | 12.5 (10.6, 14.8) | 76.6 (72.4, 80.4) | 21.7 (18.0, 25.8) | 1.7 (1.0, 2.8) | |
| Female | 86.4 (83.7, 88.7) | 13.6 (11.3, 16.3) | 74.6 (70.2, 78.5) | 23.7 (20.4, 27.3) | 1.8 (1.0, 3.0) | ||
- Page last reviewed: March 16, 2009 (archived document)
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