CCL5 Allele and Genotype Frequencies

Available polymorphism(s)

	Common Designations
rs number	Nucleotide change	Amino acid change	Genotyping method
rs2280788	-95C>G		TaqMan

---

By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs2280788		C	G		CC	CG	GG
	Non-Hispanic White	97.2 (96.8, 97.5)	2.8 (2.5, 3.2)	<0.001	94.6 (93.9, 95.2)	5.2 (4.6, 5.9)	0.2 (0.1, 0.5)	<0.001	0.04
	Non-Hispanic Black	99.3 (98.9, 99.6)	0.7 (0.4, 1.1)		98.7 (97.8, 99.2)	1.3 (0.8, 2.2)	0.0 (NA)		0.79
	Mexican American	98.7 (98.3, 99.0)	1.3 (1.0, 1.7)		97.4 (96.6, 98.0)	2.6 (2.0, 3.4)	0.0 (NA)		0.63
	Total*	97.4 (97.0, 97.7)	2.6 (2.3, 3.0)		94.9 (94.2, 95.5)	5.0 (4.4, 5.6)	0.1 (0.0, 0.4)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

 Top of Page

---

By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs2280788		C	G		CC	CG	GG
	12-19	98.0 (95.5, 99.1)	2.0 (0.9, 4.5)	0.250	96.0 (91.2, 98.2)	4.0 (1.8, 8.8)	0.0 (NA)	0.019
	20-39	96.8 (96.1, 97.4)	3.2 (2.6, 3.9)		93.7 (92.4, 94.8)	6.2 (5.2, 7.4)	0.1 (0.0, 0.6)
	40-59	97.6 (96.7, 98.2)	2.4 (1.8, 3.3)		95.3 (93.4, 96.6)	4.6 (3.2, 6.6)	0.1 (0.0, 0.8)
	>=60	97.9 (97.1, 98.5)	2.1 (1.5, 2.9)		96.0 (94.5, 97.0)	3.8 (2.9, 5.1)	0.2 (0.1, 0.7)
	Total	97.4 (97.0, 97.7)	2.6 (2.3, 3.0)		94.9 (94.2, 95.5)	5.0 (4.4, 5.6)	0.1 (0.0, 0.4)

* Includes all participants, regardless of race/ethnicity.

 Top of Page

---

By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs2280788		C	G		CC	CG	GG
	Male	97.8 (97.1, 98.3)	2.2 (1.7, 2.9)	0.172	95.6 (94.4, 96.6)	4.4 (3.4, 5.6)	0.1 (0.0, 0.5)	0.452
	Female	97.0 (96.1, 97.7)	3.0 (2.3, 3.9)		94.2 (92.6, 95.5)	5.6 (4.4, 7.1)	0.2 (0.1, 0.6)
	Total	97.4 (97.0, 97.7)	2.6 (2.3, 3.0)		94.9 (94.2, 95.5)	5.0 (4.4, 5.6)	0.1 (0.0, 0.4)

* Includes all participants, regardless of race/ethnicity.

 Top of Page

---

By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs2280788			C	G	CC	CG	GG
	Non-Hispanic White	12-19	97.9 (95.2, 99.1)	2.1 (0.9, 4.8)	95.9 (90.4, 98.3)	4.1 (1.7, 9.6)	0.0 (NA)
		20-39	96.4 (95.5, 97.2)	3.6 (2.8, 4.5)	93.1 (91.4, 94.4)	6.7 (5.4, 8.3)	0.2 (0.0, 0.8)
		40-59	97.5 (96.5, 98.2)	2.5 (1.8, 3.5)	95.1 (93.0, 96.6)	4.7 (3.2, 7.0)	0.2 (0.0, 1.0)
		>=60	97.7 (96.8, 98.4)	2.3 (1.6, 3.2)	95.7 (94.1, 96.9)	4.0 (3.0, 5.4)	0.2 (0.1, 0.9)
	Non-Hispanic Black	12-19	99.5 (98.6, 99.8)	0.5 (0.2, 1.4)	98.9 (97.2, 99.6)	1.1 (0.4, 2.8)	0.0 (NA)
		20-39	99.2 (98.4, 99.6)	0.8 (0.4, 1.6)	98.5 (96.8, 99.3)	1.5 (0.7, 3.2)	0.0 (NA)
		40-59	99.2 (98.1, 99.7)	0.8 (0.3, 1.9)	98.5 (96.1, 99.4)	1.5 (0.6, 3.9)	0.0 (NA)
		>=60	99.7 (98.7, 99.9)	0.3 (0.1, 1.3)	99.4 (97.4, 99.9)	0.6 (0.1, 2.6)	0.0 (NA)
	Mexican American	12-19	98.2 (96.2, 99.1)	1.8 (0.9, 3.8)	96.3 (92.5, 98.2)	3.7 (1.8, 7.5)	0.0 (NA)
		20-39	98.9 (98.2, 99.4)	1.1 (0.6, 1.8)	97.8 (96.4, 98.7)	2.2 (1.3, 3.6)	0.0 (NA)
		40-59	98.7 (98.0, 99.1)	1.3 (0.9, 2.0)	97.3 (95.9, 98.2)	2.7 (1.8, 4.1)	0.0 (NA)
		>=60	98.9 (97.5, 99.5)	1.1 (0.5, 2.5)	97.7 (95.1, 99.0)	2.3 (1.0, 4.9)	0.0 (NA)

---

By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs2280788			C	G	CC	CG	GG
	Non-Hispanic White	Male	97.4 (96.5, 98.0)	2.6 (2.0, 3.5)	94.9 (93.2, 96.2)	5.0 (3.8, 6.7)	0.1 (0.0, 0.7)
		Female	97.0 (96.3, 97.6)	3.0 (2.4, 3.7)	94.3 (93.0, 95.4)	5.4 (4.4, 6.7)	0.3 (0.1, 0.9)
	Non-Hispanic Black	Male	99.3 (98.6, 99.7)	0.7 (0.3, 1.4)	98.6 (97.1, 99.4)	1.4 (0.6, 2.9)	0.0 (NA)
		Female	99.4 (98.8, 99.7)	0.6 (0.3, 1.2)	98.7 (97.6, 99.4)	1.3 (0.6, 2.4)	0.0 (NA)
	Mexican American	Male	98.9 (97.8, 99.4)	1.1 (0.6, 2.2)	97.7 (95.6, 98.8)	2.3 (1.2, 4.4)	0.0 (NA)
		Female	98.5 (97.6, 99.1)	1.5 (0.9, 2.4)	97.1 (95.1, 98.3)	2.9 (1.7, 4.9)	0.0 (NA)

 Top of Page