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CAPN10 Allele and Genotype Frequencies

This website is archived for historical purposes and is no longer being maintained or updated.

Available polymorphism(s)

Common Designations

rs number

 Nucleotide change Amino acid change

Genotyping method

rs3792267

 IVS3-176G>A TaqMan

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs3792267 A G AA AG GG
Non-Hispanic White 25.8 (23.7, 27.9) 74.2 (72.1, 76.3) <0.001 6.8 (5.8, 8.0) 38.0 (35.3, 40.7) 55.2 (51.9, 58.6) <0.001 0.65
Non-Hispanic Black 16.2 (14.3, 18.2) 83.8 (81.8, 85.7) 2.4 (1.7, 3.4) 27.5 (24.5, 30.7) 70.1 (66.6, 73.4) 0.64
Mexican American 27.3 (25.3, 29.5) 72.7 (70.5, 74.7) 7.3 (6.1, 8.9) 40.0 (37.4, 42.6) 52.7 (49.5, 55.9) 0.42
Total* 24.6 (23.1, 26.1) 75.4 (73.9, 76.9) 6.4 (5.7, 7.3) 36.3 (34.4, 38.2) 57.3 (54.8, 59.7)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs3792267 A G AA AG GG
12-19 23.1 (19.8, 26.7) 76.9 (73.3, 80.2) 0.546 6.3 (4.7, 8.4) 33.5 (27.4, 40.3) 60.2 (53.6, 66.4) 0.359
20-39 25.5 (23.1, 28.0) 74.5 (72.0, 76.9) 7.2 (5.7, 9.1) 36.5 (33.2, 39.9) 56.3 (52.4, 60.1)
40-59 23.9 (21.2, 26.8) 76.1 (73.2, 78.8) 5.7 (4.0, 8.2) 36.3 (32.1, 40.8) 57.9 (53.3, 62.4)
>=60 24.8 (22.3, 27.4) 75.2 (72.6, 77.7) 5.8 (4.7, 7.1) 37.9 (33.9, 42.1) 56.3 (51.8, 60.7)
Total 24.6 (23.1, 26.1) 75.4 (73.9, 76.9) 6.4 (5.7, 7.3) 36.3 (34.4, 38.2) 57.3 (54.8, 59.7)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs3792267 A G AA AG GG
Male 24.4 (22.2, 26.7) 75.6 (73.3, 77.8) 0.749 6.8 (5.4, 8.5) 35.2 (33.0, 37.4) 58.0 (54.9, 61.1) 0.313
Female 24.7 (23.2, 26.4) 75.3 (73.6, 76.8) 6.1 (5.0, 7.3) 37.4 (34.7, 40.1) 56.6 (53.8, 59.3)
Total 24.6 (23.1, 26.1) 75.4 (73.9, 76.9) 6.4 (5.7, 7.3) 36.3 (34.4, 38.2) 57.3 (54.8, 59.7)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs3792267 A G AA AG GG
Non-Hispanic White 12-19 24.5 (19.9, 29.8) 75.5 (70.2, 80.1) 7.0 (4.6, 10.7) 35.0 (27.4, 43.3) 58.0 (49.4, 66.1)
20-39 26.9 (23.6, 30.4) 73.1 (69.6, 76.4) 7.9 (5.8, 10.7) 37.8 (33.7, 42.1) 54.2 (49.1, 59.3)
40-59 24.6 (20.9, 28.7) 75.4 (71.3, 79.1) 5.4 (3.5, 8.4) 38.3 (32.4, 44.6) 56.3 (49.6, 62.7)
>=60 26.2 (23.3, 29.2) 73.8 (70.8, 76.7) 6.5 (5.2, 8.0) 39.5 (34.8, 44.3) 54.1 (48.9, 59.2)
Non-Hispanic Black 12-19 16.2 (13.8, 18.9) 83.8 (81.1, 86.2) 2.1 (1.0, 4.1) 28.3 (23.8, 33.3) 69.6 (64.7, 74.2)
20-39 16.0 (13.6, 18.7) 84.0 (81.3, 86.4) 2.5 (1.5, 4.1) 27.1 (23.4, 31.2) 70.4 (65.9, 74.6)
40-59 16.2 (14.0, 18.6) 83.8 (81.4, 86.0) 2.7 (1.6, 4.5) 27.0 (22.5, 32.0) 70.3 (65.7, 74.6)
>=60 16.5 (13.0, 20.6) 83.5 (79.4, 87.0) 2.1 (0.9, 4.6) 28.8 (22.7, 35.7) 69.2 (61.9, 75.6)
Mexican American 12-19 29.7 (26.7, 33.0) 70.3 (67.0, 73.3) 7.4 (5.2, 10.4) 44.7 (39.1, 50.4) 47.9 (42.6, 53.3)
20-39 26.3 (24.3, 28.3) 73.7 (71.7, 75.7) 6.7 (5.5, 8.1) 39.2 (36.9, 41.5) 54.1 (51.1, 57.1)
40-59 28.0 (22.8, 33.8) 72.0 (66.2, 77.2) 9.2 (6.1, 13.8) 37.5 (31.3, 44.2) 53.3 (45.0, 61.3)
>=60 26.1 (23.9, 28.4) 73.9 (71.6, 76.1) 6.3 (4.2, 9.3) 39.6 (34.9, 44.5) 54.1 (50.2, 58.1)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs3792267 A G AA AG GG
Non-Hispanic White Male 25.4 (22.5, 28.5) 74.6 (71.5, 77.5) 7.3 (5.4, 9.8) 36.3 (33.2, 39.4) 56.5 (52.1, 60.7)
Female 26.1 (24.1, 28.2) 73.9 (71.8, 75.9) 6.3 (4.8, 8.2) 39.6 (35.6, 43.7) 54.1 (50.4, 57.8)
Non-Hispanic Black Male 16.3 (14.1, 18.8) 83.7 (81.2, 85.9) 2.4 (1.5, 3.9) 27.9 (24.1, 32.0) 69.7 (65.4, 73.8)
Female 16.0 (13.8, 18.6) 84.0 (81.4, 86.2) 2.4 (1.6, 3.7) 27.2 (23.8, 31.0) 70.4 (66.1, 74.3)
Mexican American Male 26.6 (24.5, 28.9) 73.4 (71.1, 75.5) 7.1 (5.4, 9.2) 39.2 (36.6, 41.8) 53.8 (50.7, 56.8)
Female 28.1 (25.0, 31.3) 71.9 (68.7, 75.0) 7.6 (6.0, 9.7) 40.8 (36.3, 45.5) 51.5 (46.3, 56.7)

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