Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

ADRB2 Allele and Genotype Frequencies

This website is archived for historical purposes and is no longer being maintained or updated.

Available polymorphism(s)

Common Designations

rs number

 Nucleotide change Amino acid change

Genotyping method

rs1042713

 Ex1+265G>A Gly16Arg TaqMan
rs1042714 Ex1+298G>C Glu27Gln Pyrosequencing

 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs1042713 A G AA AG GG
Non-Hispanic White 38.9 (36.9, 40.9) 61.1 (59.1, 63.1) <0.001 15.7 (13.4, 18.2) 46.4 (43.6, 49.3) 37.9 (35.4, 40.4) <0.001 0.96
Non-Hispanic Black 49.7 (47.7, 51.6) 50.3 (48.4, 52.3) 25.0 (23.1, 27.1) 49.3 (47.0, 51.7) 25.6 (23.2, 28.3) 0.43
Mexican American 41.8 (40.3, 43.2) 58.2 (56.8, 59.7) 15.6 (14.4, 16.9) 52.3 (50.1, 54.4) 32.1 (29.9, 34.4) 0.14
Total* 40.5 (38.9, 42.2) 59.5 (57.8, 61.1) 16.9 (15.0, 18.9) 47.3 (45.0, 49.6) 35.8 (33.7, 38.0)
rs1042714 C G CC CG GG
Non-Hispanic White 58.1 (56.0, 60.1) 41.9 (39.9, 44.0) <0.001 34.5 (31.6, 37.5) 47.3 (44.4, 50.1) 18.3 (16.3, 20.4) <0.001 0.74
Non-Hispanic Black 82.0 (80.4, 83.4) 18.0 (16.6, 19.6) 67.6 (64.9, 70.2) 28.8 (26.2, 31.5) 3.7 (2.7, 5.0) 0.16
Mexican American 78.7 (77.1, 80.2) 21.3 (19.8, 22.9) 61.4 (58.8, 63.9) 34.6 (32.1, 37.2) 4.0 (3.1, 5.2) 0.66
Total* 64.0 (62.1, 65.9) 36.0 (34.1, 37.9) 42.5 (40.2, 44.8) 43.0 (41.0, 45.0) 14.5 (12.7, 16.5)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

 Top of Page

By Age*

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1042713 A G AA AG GG
12-19 41.8 (38.2, 45.4) 58.2 (54.6, 61.8) 0.624 18.9 (15.5, 22.8) 45.8 (40.4, 51.4) 35.3 (30.3, 40.7) 0.377
20-39 40.7 (37.9, 43.5) 59.3 (56.5, 62.1) 16.7 (13.9, 19.9) 48.0 (44.0, 52.1) 35.3 (31.5, 39.3)
40-59 40.9 (37.9, 43.9) 59.1 (56.1, 62.1) 17.7 (14.9, 20.9) 46.3 (42.7, 50.0) 36.0 (32.2, 40.0)
>=60 39.0 (36.9, 41.1) 61.0 (58.9, 63.1) 14.8 (13.3, 16.5) 48.3 (46.0, 50.6) 36.9 (33.9, 39.9)
Total 40.5 (38.9, 42.2) 59.5 (57.8, 61.1) 16.9 (15.0, 18.9) 47.3 (45.0, 49.6) 35.8 (33.7, 38.0)
rs1042714 C G CC CG GG
12-19 65.3 (62.0, 68.6) 34.7 (31.4, 38.0) 0.010 45.2 (41.3, 49.3) 40.2 (36.1, 44.4) 14.6 (11.2, 18.8) 0.038
20-39 66.0 (63.8, 68.2) 34.0 (31.8, 36.2) 45.5 (42.5, 48.6) 41.1 (38.4, 43.7) 13.4 (11.5, 15.6)
40-59 61.7 (58.0, 65.2) 38.3 (34.8, 42.0) 39.3 (35.1, 43.6) 44.9 (40.7, 49.2) 15.9 (12.2, 20.4)
>=60 62.2 (60.1, 64.3) 37.8 (35.7, 39.9) 39.0 (36.0, 42.2) 46.3 (43.0, 49.6) 14.7 (12.6, 16.9)
Total 64.0 (62.1, 65.9) 36.0 (34.1, 37.9) 42.5 (40.2, 44.8) 43.0 (41.0, 45.0) 14.5 (12.7, 16.5)

* Includes all participants, regardless of race/ethnicity.

 Top of Page

By Sex*

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1042713 A G AA AG GG
Male 40.3 (38.1, 42.5) 59.7 (57.5, 61.9) 0.702 16.0 (13.7, 18.5) 48.6 (44.8, 52.4) 35.4 (32.1, 38.9) 0.424
Female 40.8 (38.6, 43.0) 59.2 (57.0, 61.4) 17.8 (15.5, 20.3) 46.1 (43.0, 49.2) 36.2 (33.3, 39.2)
Total 40.5 (38.9, 42.2) 59.5 (57.8, 61.1) 16.9 (15.0, 18.9) 47.3 (45.0, 49.6) 35.8 (33.7, 38.0)
rs1042714 C G CC CG GG
Male 64.6 (62.1, 67.0) 35.4 (33.0, 37.9) 0.435 42.5 (39.6, 45.5) 44.2 (41.2, 47.2) 13.3 (10.8, 16.4) 0.306
Female 63.4 (61.1, 65.8) 36.6 (34.2, 38.9) 42.5 (39.4, 45.5) 42.0 (39.4, 44.5) 15.6 (13.5, 17.9)
Total 64.0 (62.1, 65.9) 36.0 (34.1, 37.9) 42.5 (40.2, 44.8) 43.0 (41.0, 45.0) 14.5 (12.7, 16.5)

* Includes all participants, regardless of race/ethnicity.

 Top of Page

By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs1042713 A G AA AG GG
Non-Hispanic White 12-19 40.4 (35.8, 45.2) 59.6 (54.8, 64.2) 18.1 (13.8, 23.3) 44.6 (37.5, 52.0) 37.3 (30.6, 44.5)
20-39 39.2 (35.3, 43.2) 60.8 (56.8, 64.7) 15.6 (11.9, 20.1) 47.1 (42.0, 52.3) 37.3 (32.2, 42.7)
40-59 38.6 (35.1, 42.2) 61.4 (57.8, 64.9) 15.9 (12.6, 20.0) 45.4 (41.3, 49.5) 38.7 (34.4, 43.3)
>=60 37.9 (35.4, 40.5) 62.1 (59.5, 64.6) 14.1 (12.2, 16.2) 47.8 (45.3, 50.2) 38.2 (34.8, 41.7)
Non-Hispanic Black 12-19 47.8 (42.0, 53.7) 52.2 (46.3, 58.0) 24.6 (19.4, 30.6) 46.5 (41.3, 51.8) 29.0 (22.3, 36.6)
20-39 49.5 (47.0, 52.0) 50.5 (48.0, 53.0) 25.0 (22.6, 27.5) 49.0 (45.7, 52.4) 26.0 (22.7, 29.6)
40-59 51.6 (46.9, 56.2) 48.4 (43.8, 53.1) 25.5 (20.2, 31.6) 52.2 (47.4, 56.9) 22.3 (18.0, 27.4)
>=60 49.3 (44.6, 54.1) 50.7 (45.9, 55.4) 24.8 (20.5, 29.8) 49.0 (43.8, 54.2) 26.2 (20.6, 32.7)
Mexican American 12-19 44.3 (40.6, 48.2) 55.7 (51.8, 59.4) 17.3 (12.7, 23.2) 54.1 (48.9, 59.2) 28.6 (24.9, 32.6)
20-39 41.1 (38.9, 43.4) 58.9 (56.6, 61.1) 13.9 (12.4, 15.5) 54.5 (50.7, 58.2) 31.6 (27.9, 35.6)
40-59 41.4 (39.0, 43.8) 58.6 (56.2, 61.0) 18.3 (15.2, 21.8) 46.2 (40.1, 52.5) 35.5 (31.1, 40.2)
>=60 40.1 (35.8, 44.7) 59.9 (55.3, 64.2) 14.9 (11.0, 20.0) 50.4 (43.8, 57.0) 34.6 (28.5, 41.4)
rs1042714 C G CC CG GG
Non-Hispanic White 12-19 57.6 (52.7, 62.4) 42.4 (37.6, 47.3) 35.9 (30.2, 41.9) 43.6 (37.7, 49.7) 20.6 (15.5, 26.7)
20-39 59.5 (56.7, 62.2) 40.5 (37.8, 43.3) 36.8 (32.9, 40.9) 45.3 (41.7, 49.0) 17.9 (15.5, 20.5)
40-59 56.1 (51.5, 60.6) 43.9 (39.4, 48.5) 31.4 (26.4, 36.9) 49.4 (44.4, 54.3) 19.2 (14.7, 24.8)
>=60 58.7 (56.6, 60.7) 41.3 (39.3, 43.4) 33.8 (31.0, 36.8) 49.7 (46.2, 53.3) 16.5 (14.1, 19.0)
Non-Hispanic Black 12-19 80.0 (77.2, 82.6) 20.0 (17.4, 22.8) 64.5 (59.6, 69.1) 31.1 (26.1, 36.6) 4.4 (2.5, 7.6)
20-39 82.7 (79.8, 85.3) 17.3 (14.7, 20.2) 69.4 (64.5, 74.0) 26.5 (22.2, 31.4) 4.0 (2.7, 6.0)
40-59 81.6 (78.6, 84.3) 18.4 (15.7, 21.4) 66.7 (61.4, 71.6) 29.8 (25.1, 34.9) 3.5 (2.3, 5.4)
>=60 82.9 (79.5, 85.9) 17.1 (14.1, 20.5) 67.6 (60.8, 73.7) 30.6 (24.2, 37.9) 1.8 (0.7, 4.2)
Mexican American 12-19 79.7 (73.7, 84.7) 20.3 (15.3, 26.3) 63.2 (54.1, 71.5) 33.0 (26.3, 40.6) 3.7 (1.6, 8.4)
20-39 78.2 (75.9, 80.3) 21.8 (19.7, 24.1) 60.1 (56.7, 63.4) 36.2 (33.3, 39.2) 3.7 (2.4, 5.6)
40-59 79.6 (74.7, 83.8) 20.4 (16.2, 25.3) 63.3 (55.3, 70.7) 32.6 (26.3, 39.6) 4.1 (2.6, 6.4)
>=60 76.8 (70.2, 82.3) 23.2 (17.7, 29.8) 59.7 (49.8, 68.9) 34.2 (26.9, 42.2) 6.1 (3.6, 10.1)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs1042713 A G AA AG GG
Non-Hispanic White Male 38.9 (36.4, 41.4) 61.1 (58.6, 63.6) 15.0 (12.4, 17.9) 47.9 (42.7, 53.1) 37.1 (33.0, 41.5)
Female 38.9 (36.2, 41.6) 61.1 (58.4, 63.8) 16.3 (13.8, 19.2) 45.1 (41.7, 48.5) 38.6 (35.0, 42.3)
Non-Hispanic Black Male 49.7 (46.7, 52.8) 50.3 (47.2, 53.3) 24.9 (21.8, 28.3) 49.7 (45.8, 53.6) 25.4 (21.7, 29.6)
Female 49.6 (47.3, 52.0) 50.4 (48.0, 52.7) 25.1 (22.9, 27.5) 49.0 (46.0, 52.0) 25.8 (22.8, 29.2)
Mexican American Male 41.7 (39.7, 43.7) 58.3 (56.3, 60.3) 15.5 (13.6, 17.7) 52.4 (49.4, 55.4) 32.1 (29.2, 35.0)
Female 41.8 (39.5, 44.1) 58.2 (55.9, 60.5) 15.7 (13.8, 17.8) 52.1 (49.0, 55.3) 32.2 (28.8, 35.7)
rs1042714 C G CC CG GG
Non-Hispanic White Male 58.9 (56.5, 61.4) 41.1 (38.6, 43.5) 34.8 (31.8, 38.0) 48.3 (44.5, 52.1) 16.9 (14.0, 20.3)
Female 57.3 (54.2, 60.3) 42.7 (39.7, 45.8) 34.2 (30.2, 38.4) 46.3 (42.7, 49.9) 19.6 (16.9, 22.6)
Non-Hispanic Black Male 82.5 (80.5, 84.4) 17.5 (15.6, 19.5) 67.9 (64.8, 70.8) 29.3 (26.8, 31.9) 2.8 (1.8, 4.4)
Female 81.5 (79.7, 83.2) 18.5 (16.8, 20.3) 67.4 (64.0, 70.6) 28.3 (24.9, 32.0) 4.3 (3.1, 6.0)
Mexican American Male 78.7 (76.8, 80.5) 21.3 (19.5, 23.2) 61.5 (57.9, 65.0) 34.4 (30.5, 38.5) 4.1 (2.8, 6.1)
Female 78.7 (76.8, 80.4) 21.3 (19.6, 23.2) 61.2 (58.7, 63.7) 34.9 (32.9, 36.9) 3.9 (2.6, 5.8)

 Top of Page

TOP