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ADRB1 Allele and Genotype Frequencies

This website is archived for historical purposes and is no longer being maintained or updated.

Available polymorphism(s)

Common Designations

rs number

 Nucleotide change Amino acid change

Genotyping method

rs1801252

 Ex1+231A>G Ser49Gly MGB Eclipse

 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs1801252 A G AA AG GG
Non-Hispanic White 86.8 (84.5, 88.8) 13.2 (11.2, 15.5) <0.001 75.8 (72.2, 79.0) 22.0 (19.4, 24.9) 2.2 (1.4, 3.6) <0.001 0.11
Non-Hispanic Black 77.5 (76.0, 79.0) 22.5 (21.0, 24.0) 60.3 (57.5, 63.1) 34.4 (31.2, 37.8) 5.2 (4.1, 6.7) 0.78
Mexican American 72.0 (70.1, 73.8) 28.0 (26.2, 29.9) 51.8 (48.8, 54.9) 40.3 (37.7, 42.9) 7.9 (6.8, 9.1) 0.83
Total* 84.3 (82.3, 86.2) 15.7 (13.8, 17.7) 71.5 (68.3, 74.5) 25.6 (23.3, 28.1) 2.8 (2.1, 3.8)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1801252 A G AA AG GG
12-19 83.2 (78.5, 87.0) 16.8 (13.0, 21.5) 0.245 69.3 (61.5, 76.2) 27.6 (21.7, 34.5) 3.0 (1.8, 5.2) 0.364
20-39 83.5 (81.4, 85.5) 16.5 (14.5, 18.6) 70.2 (66.8, 73.4) 26.6 (23.6, 29.8) 3.2 (2.0, 4.9)
40-59 85.4 (82.5, 87.9) 14.6 (12.1, 17.5) 73.1 (68.2, 77.5) 24.6 (20.7, 28.9) 2.3 (1.4, 3.8)
>=60 85.3 (83.5, 87.0) 14.7 (13.0, 16.5) 73.5 (69.8, 76.8) 23.7 (20.3, 27.5) 2.8 (2.2, 3.5)
Total 84.3 (82.3, 86.2) 15.7 (13.8, 17.7) 71.5 (68.3, 74.5) 25.6 (23.3, 28.1) 2.8 (2.1, 3.8)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1801252 A G AA AG GG
Male 84.2 (81.7, 86.5) 15.8 (13.5, 18.3) 0.858 71.4 (67.5, 74.9) 25.7 (23.1, 28.6) 2.9 (1.8, 4.5) 0.984
Female 84.4 (82.3, 86.4) 15.6 (13.6, 17.7) 71.7 (68.0, 75.1) 25.5 (22.5, 28.8) 2.8 (2.1, 3.7)
Total 84.3 (82.3, 86.2) 15.7 (13.8, 17.7) 71.5 (68.3, 74.5) 25.6 (23.3, 28.1) 2.8 (2.1, 3.8)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs1801252 A G AA AG GG
Non-Hispanic White 12-19 86.9 (80.9, 91.2) 13.1 (8.8, 19.1) 76.0 (66.5, 83.5) 21.8 (15.4, 29.9) 2.2 (0.7, 6.4)
20-39 86.4 (83.8, 88.7) 13.6 (11.3, 16.2) 75.4 (71.5, 78.8) 22.1 (18.9, 25.8) 2.5 (1.1, 5.7)
40-59 87.7 (84.9, 90.1) 12.3 (9.9, 15.1) 76.8 (71.7, 81.3) 21.8 (17.5, 26.7) 1.4 (0.7, 2.9)
>=60 86.0 (84.4, 87.5) 14.0 (12.5, 15.6) 74.9 (71.7, 77.9) 22.2 (19.1, 25.8) 2.8 (2.2, 3.6)
Non-Hispanic Black 12-19 77.9 (74.7, 80.8) 22.1 (19.2, 25.3) 60.5 (55.3, 65.5) 34.8 (30.0, 40.0) 4.7 (2.9, 7.5)
20-39 76.9 (75.2, 78.6) 23.1 (21.4, 24.8) 60.0 (56.8, 63.2) 33.8 (29.7, 38.1) 6.2 (4.3, 8.8)
40-59 76.5 (73.6, 79.1) 23.5 (20.9, 26.4) 58.3 (53.6, 62.8) 36.4 (31.9, 41.0) 5.3 (3.6, 7.8)
>=60 80.8 (77.4, 83.8) 19.2 (16.2, 22.6) 64.6 (58.2, 70.6) 32.4 (26.4, 39.0) 3.0 (1.8, 4.9)
Mexican American 12-19 70.5 (65.6, 75.1) 29.5 (24.9, 34.4) 50.5 (42.7, 58.3) 40.0 (33.2, 47.2) 9.4 (7.0, 12.7)
20-39 71.9 (69.2, 74.4) 28.1 (25.6, 30.8) 51.3 (47.0, 55.7) 41.0 (37.3, 44.9) 7.6 (6.3, 9.1)
40-59 73.0 (70.7, 75.2) 27.0 (24.8, 29.3) 53.3 (49.8, 56.7) 39.6 (35.9, 43.4) 7.2 (5.2, 9.8)
>=60 73.4 (67.2, 78.8) 26.6 (21.2, 32.8) 54.2 (44.3, 63.8) 38.4 (29.8, 47.8) 7.4 (4.7, 11.6)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs1801252 A G AA AG GG
Non-Hispanic White Male 86.6 (83.6, 89.0) 13.4 (11.0, 16.4) 75.3 (70.8, 79.4) 22.4 (19.2, 26.1) 2.2 (1.1, 4.3)
Female 87.0 (84.5, 89.1) 13.0 (10.9, 15.5) 76.2 (72.1, 79.8) 21.6 (18.4, 25.2) 2.2 (1.3, 3.8)
Non-Hispanic Black Male 78.1 (76.1, 80.1) 21.9 (19.9, 23.9) 60.9 (57.6, 64.1) 34.4 (31.0, 38.1) 4.7 (3.1, 7.0)
Female 77.1 (75.2, 78.8) 22.9 (21.2, 24.8) 59.9 (56.4, 63.3) 34.4 (30.6, 38.4) 5.7 (4.5, 7.3)
Mexican American Male 71.9 (69.8, 73.9) 28.1 (26.1, 30.2) 52.2 (48.8, 55.6) 39.4 (36.3, 42.6) 8.4 (7.2, 9.7)
Female 72.1 (69.2, 74.8) 27.9 (25.2, 30.8) 51.5 (46.8, 56.1) 41.2 (37.1, 45.5) 7.3 (5.8, 9.1)

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