Sitagliptin/metformin

Sitagliptin/metformin, sold under the brand name Janumet among others, is a combination medication used to treat type 2 diabetes.[1] It may be used in those whose blood sugar is not controlled with metformin and a sulfonylurea.[1][2] It is taken by mouth.[1]

Sitagliptin/metformin
Combination of
SitagliptinDipeptidyl peptidase-4 inhibitor
MetforminBiguanide
Clinical data
Trade namesJanumet, Januet, other
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
KEGG

Common side effects include diarrhea, headache, and upper respiratory tract infections.[3] Serious side effects may include lactic acidosis, pancreatitis, low blood sugar, heart failure, joint pain, and allergic reactions.[3] It has not been properly studied in people who are pregnant or breastfeeding.[4] It contains sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin (a biguanide).[3]

The combination was approved for medical use in the United States in 2007.[3] A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019.[1] In the United States the wholesale cost of this amount is about 433 USD.[5] In 2016 it was the 191st most prescribed medication in the United States with more than 3 million prescriptions.[6]

Society and culture

Brand names

As of 2018 the combination was marketed under several brand names, including Efficib, Janmet, Januet, Janumet, Jznumet, Ristaben Met, Ristfor, Siglimet, Sitamet, Sitar-M, Sliptin-M, Treviamet, and Velmetia.[7]

Price

A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019.[1] In the United States the wholesale cost of this amount is about 433 USD.[5] In Denmark 100 tablets (each 1,000 mg) cost over the counter in a pharmacy DKK 62.60 = US$ 9.40 = £7.50, thus a month supply in Denmark costs DKK 37.50 = US$ 5.70 = £ 4.50. The pharmacy buys wholesale at DKK 33.83 = US$ 5.11 = £4.10.[8]

References
  1. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 682. ISBN 9780857113382.
  2. Hayes, J; Anderson, R; Stephens, JW (2016). "Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy". Drug Design, Development and Therapy. 10: 2263–70. doi:10.2147/DDDT.S93076. PMC 4958358. PMID 27486305.
  3. "Janumet - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
  4. "Metformin / sitagliptin Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
  5. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  6. "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.
  7. "International brands for Sitagliptin/metformin". Drugs.com. Retrieved 3 September 2018.
  8. "Medicinpriser". Medicinpriser (in Danish). Retrieved 17 June 2019.
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