Neridronic acid

Neridronic acid
Clinical data
ATC code	none;
Identifiers
	IUPAC name (6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid);
CAS Number	79778-41-9 ;
PubChem CID	71237;
ChemSpider	64372 ;
UNII	8U27U3RIN4;
ECHA InfoCard	100.163.818
Chemical and physical data
Formula	C6H17NO7P2
Molar mass	277.14 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN;
	InChI InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14) ; Key:PUUSSSIBPPTKTP-UHFFFAOYSA-N ;
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Neridronic acid (INN; the anion is called neridronate) is a bisphosphonate. In Italy it is used to treat Osteogenesis imperfecta and Paget's disease of bone.[1]

A 2013 clinical trial suggests CRPS Type I (Complex regional pain syndrome) responds to treatment with intravenous neridronate.[2]

References

Gatti D, Viapiana O, Idolazzi L, Fracassi E, Adami S. "Neridronic acid for the treatment of bone metabolic diseases". Expert Opin Drug Metab Toxicol. 5: 1305–11. doi:10.1517/17425250903029190. PMID 19761412.
Varenna M, Adami S, Rossini M, et al. (March 2013). "Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study". Rheumatology. 52 (3): 534–42. doi:10.1093/rheumatology/kes312. PMID 23204550.

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Drugs for treatment of bone diseases (M05)
Bisphosphonates	Nitrogenous (Alendronic acid ibandronic acid incadronic acid pamidronic acid risedronic acid zoledronic acid) Non-nitrogenous (Etidronic acid clodronic acid tiludronic acid)
Bone morphogenetic proteins	Dibotermin alfa Eptotermin alfa
Other	Resorption inhibitor (Ipriflavone) Aluminium chlorohydrate Dual action bone agent (Strontium ranelate) RANKL inhibitor (Denosumab) Sclerostin inhibitor (Romosozumab) Cathepsin K inhibitor (Odanacatib) Calcium Vitamin D