Letermovir

Letermovir
Clinical data
Trade names	Prevymis
Other names	AIC246; MK-8228
Routes of; administration	Oral
ATC code	J05AX18 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Identifiers
	IUPAC name {(4S)-8-Fluoro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl}acetic acid;
PubChem CID	45138674;
ChemSpider	26352849;
UNII	1H09Y5WO1F;
KEGG	D10801 ;
ChEMBL	ChEMBL1241951;
CompTox Dashboard (EPA)	DTXSID40238683 ;
ECHA InfoCard	100.232.644
Chemical and physical data
Formula	C29H28F4N4O4
Molar mass	572.561 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C(C=C(C=C1)C(F)(F)F)N2[C@H](C3=C(C(=CC=C3)F)N=C2N4CCN(CC4)C5=CC(=CC=C5)OC)CC(=O)O;
	InChI InChI=1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1; Key:FWYSMLBETOMXAG-QHCPKHFHSA-N;

Letermovir (INN; trade name Prevymis) is an antiviral drug for the treatment of cytomegalovirus (CMV) infections. It has been tested in CMV infected patients with allogeneic stem cell transplants and may also be useful for other patients with a compromised immune system such as those with organ transplants or HIV infections.[1] The drug was developed by Merck & Co., Inc as investigative compound MK-8228.[2]

The drug was granted fast track status by the US Food and Drug Administration (FDA) and orphan drug status by the European Medicines Agency.[1] In the United States, it is approved for prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant.[3]

References

"Neues Virostatikum Letermovir" (in German). Deutsche Apothekerzeitung. 2011-08-29.
Masangkay, Estel Grace (July 29, 2014). "Merck Kicks Off Phase 3 Study Of CMV Drug Letermovir". Retrieved 8 Oct 2014.
"FDA Approves Letermovir for CMV Prophylaxis Post-Transplantation". onclive.com. November 9, 2017.

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[DAZ-1] "Neues Virostatikum Letermovir" (in German). Deutsche Apothekerzeitung. 2011-08-29.

[2] Masangkay, Estel Grace (July 29, 2014). "Merck Kicks Off Phase 3 Study Of CMV Drug Letermovir". Retrieved 8 Oct 2014.

[3] "FDA Approves Letermovir for CMV Prophylaxis Post-Transplantation". onclive.com. November 9, 2017.