Esterom

Esterom is an investigational drug being studied as a topical analgesic. Chemically, it is a mixture of compounds derived from the esterification of cocaine in propylene glycol.[1] While the major component is benzoylecgonine,[2] the analgesic activity is likely to due to hydroxypropyl benzoylecgonine, the only component that penetrates the skin.[1][3]

Esterom
Benzoylecgonine (top), the major component, and hydroxypropyl benzoylecgonine (bottom), the most active component
Clinical data
Trade namesEsterom
Identifiers
DrugBank

References
  1. McDonald, Sarah; Lunte, Craig (2003). "Determination of the Dermal Penetration of Esterom Components Using Microdialysis Sampling". Pharmaceutical Research. 20 (11): 1827. doi:10.1023/B:PHAM.0000003381.10208.8c. PMC 2519827. PMID 14661928.
  2. Razak, Jennifer L; Doyen, Heidi J; Lunte, Craig E (2003). "Cyclodextrin-modified micellar electrokinetic chromatography for the analysis of Esterom®, a topical product consisting of hydrolyzed benzoylecgonine in propylene glycol". Electrophoresis. 24 (11): 1764. doi:10.1002/elps.200305374. PMC 2519819. PMID 12783453.
  3. Yoshihiro Hamaya, Hesham Abdelrazek, Gary R. Strichartz (2002). "A-854: Comparative Potency for Impulse-Blockade and for Cutaneous Analgesia of Traditional and Novel Local Anesthetics". Abstracts of American Society of Anesthesiologists Annual Meeting. ...hydroxypropylbenzoylecgonine (HPBE) is the only effective analgesic compound in [Esterom].CS1 maint: multiple names: authors list (link)
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