Clefamide

Clefamide
Clinical data
Trade names	Mebinol
ATC code	P01AC02 (WHO) ;
Identifiers
	IUPAC name 2,2-Dichloro-N-(2-hydroxyethyl)-N-[[4-(4-nitrophenoxy)phenyl]methyl];
CAS Number	3576-64-5;
PubChem CID	71819;
ChemSpider	64843 ;
UNII	4AZ2V8K4EK;
KEGG	D07354 ;
ChEMBL	ChEMBL1788400;
CompTox Dashboard (EPA)	DTXSID30189296 ;
ECHA InfoCard	100.020.631
Chemical and physical data
Formula	C17H16Cl2N2O5
Molar mass	399.23 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC(Cl)C(=O)N(CCO)Cc2ccc(Oc1ccc(cc1)[N+]([O-])=O)cc2;
	InChI InChI=1S/C17H16Cl2N2O5/c18-16(19)17(23)20(9-10-22)11-12-1-5-14(6-2-12)26-15-7-3-13(4-8-15)21(24)25/h1-8,16,22H,9-11H2 ; Key:ODCUSWJXZDHLKV-UHFFFAOYSA-N ;
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Clefamide (trade name Mebinol) is an antiprotozoal agent that was used to treat amoebiasis in the 1960s.[1] There is no evidence for any later use of the drug.

References

Rodrigues, L. D.; Jafferian, P. A.; Vilella Mde, P.; Costa, A. A.; De Mello, E. B. (1968). "Comparative study on 3 amebicides: Teclozine, clefamide and a combination of clefamide and iodo-chloro-oxyquinolines and streptomycin". Hospital (Rio de Janeiro, Brazil). 74 (5): 1563–1573. PMID 5305335.

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[1] Rodrigues, L. D.; Jafferian, P. A.; Vilella Mde, P.; Costa, A. A.; De Mello, E. B. (1968). "Comparative study on 3 amebicides: Teclozine, clefamide and a combination of clefamide and iodo-chloro-oxyquinolines and streptomycin". Hospital (Rio de Janeiro, Brazil). 74 (5): 1563–1573. PMID 5305335.