Biphasic disease

A biphasic disease is a disease which has two distinct phases or components. In clinically biphasic diseases, the phases are generally chronologically separated. In histopathologically biphasic tumors (also called biplastic tumors), there is neoplastic tissue which contains two different cellular elements.[1][2]

Examples

Clinically biphasic diseases

Disease	Typical first phase	Typical second phase
European (or "Western") subtype of tick-borne encephalitis virus[3][4]	Relatively mild flu-like illness	Affecting some cases, generally presenting with high fever and neurologic disease (encephalitis), meningitis and/or meningoencephalitis)
Leptospirosis[5]	4–9 days of abrupt onset of flu-like illness	Fever, jaundice, abdominal pain and diarrhoea. Organ failure in severe cases.

Tumor biplasia

Disease	Cellular elements
Fibroadenoma[6]	Epithelium	Stroma
Ceruminous adenoma[7]	Inner luminal secretory cells	Myoepithelial cells

References

Santosh, Arvind Babu Rajendra (2014). "Histogenetic Concepts, Terminology and Categorization of Biphasic Tumours of the Oral and Maxillofacial Region". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. doi:10.7860/JCDR/2014/7506.4078. ISSN 2249-782X.
"Fibroadenoma". Patholines.org. This page was last edited on 4 November 2019
Veje, Malin; Studahl, Marie; Johansson, Maja; Johansson, Patrik; Nolskog, Peter; Bergström, Tomas (2017). "Diagnosing tick-borne encephalitis: a re-evaluation of notified cases". European Journal of Clinical Microbiology & Infectious Diseases. 37 (2): 339–344. doi:10.1007/s10096-017-3139-9. ISSN 0934-9723.
Kaiser R (September 2008). "Tick-borne encephalitis". Infect. Dis. Clin. North Am. 22 (3): 561–75, x. doi:10.1016/j.idc.2008.03.013. PMID 18755391.
"Factsheet about leptospirosis". European Centre for Disease Prevention and Control. Page last updated 26 Jun 2017
Tavassoli, F.A.; Devilee, P., eds. (2003). World Health Organization Classification of Tumours: Pathology & Genetics: Tumours of the breast and female genital organs. Lyon: IARC Press. ISBN 978-92-832-2412-9.
Thompson LD, Nelson BL, Barnes EL (Mar 2004). "Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature". Am J Surg Pathol. 28 (3): 308–18. doi:10.1097/00000478-200403000-00003. PMID 15104293.

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[Santosh2014-1] Santosh, Arvind Babu Rajendra (2014). "Histogenetic Concepts, Terminology and Categorization of Biphasic Tumours of the Oral and Maxillofacial Region". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. doi:10.7860/JCDR/2014/7506.4078. ISSN 2249-782X.

[2] "Fibroadenoma". Patholines.org. This page was last edited on 4 November 2019

[VejeStudahl2017-3] Veje, Malin; Studahl, Marie; Johansson, Maja; Johansson, Patrik; Nolskog, Peter; Bergström, Tomas (2017). "Diagnosing tick-borne encephalitis: a re-evaluation of notified cases". European Journal of Clinical Microbiology & Infectious Diseases. 37 (2): 339–344. doi:10.1007/s10096-017-3139-9. ISSN 0934-9723.

[pmid18755391-4] Kaiser R (September 2008). "Tick-borne encephalitis". Infect. Dis. Clin. North Am. 22 (3): 561–75, x. doi:10.1016/j.idc.2008.03.013. PMID 18755391.

[5] "Factsheet about leptospirosis". European Centre for Disease Prevention and Control. Page last updated 26 Jun 2017

[WHO-6] Tavassoli, F.A.; Devilee, P., eds. (2003). World Health Organization Classification of Tumours: Pathology & Genetics: Tumours of the breast and female genital organs. Lyon: IARC Press. ISBN 978-92-832-2412-9.

[Thompson-7] Thompson LD, Nelson BL, Barnes EL (Mar 2004). "Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature". Am J Surg Pathol. 28 (3): 308–18. doi:10.1097/00000478-200403000-00003. PMID 15104293.