AG 489

AG 489
Names
	IUPAC name N-[3-[3-[3-[4-(3-aminopropylamino) butylamino] propylamino]propyl-hydroxyamino] propyl]-2-(1H-indol-3-yl)acetamide
	Other names Agatoxin 489
Identifiers
CAS Number	128549-96-2 ;
3D model (JSmol)	Interactive image;
ChemSpider	115840 ;
IUPHAR/BPS	2484;
PubChem CID	131007;
CompTox Dashboard (EPA)	DTXSID40155922 ;
	InChI InChI=1S/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34) Key: LIURIBSBVUMOJS-UHFFFAOYSA-N ; InChI=1/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34) Key: LIURIBSBVUMOJS-UHFFFAOYAP;
	SMILES O=C(NCCCN(O)CCCNCCCNCCCCNCCCN)Cc2c1ccccc1[nH]c2;
Properties
Chemical formula	C26H47N7O2
Molar mass	489.69708
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

AG 489 (or agatoxin 489) is a component of the venom produced by Agelenopsis aperta.[1] It inhibits the ligand gated ion channel TRPV1 through a pore blocking mechanism.[2]

References

Herold EE, Yaksh TL (1992). "Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat". Anesthesiology. 77 (3): 507–12. doi:10.1097/00000542-199209000-00016. PMID 1519789.
Kitaguchi T, Swartz KJ (2005). "An inhibitor of TRPV1 channels isolated from funnel Web spider venom". Biochemistry. 44 (47): 15544–9. doi:10.1021/bi051494l. PMID 16300403.

External links

AG+489 at the US National Library of Medicine Medical Subject Headings (MeSH)

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[pmid1519789-1] Herold EE, Yaksh TL (1992). "Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat". Anesthesiology. 77 (3): 507–12. doi:10.1097/00000542-199209000-00016. PMID 1519789.

[pmid16300403-2] Kitaguchi T, Swartz KJ (2005). "An inhibitor of TRPV1 channels isolated from funnel Web spider venom". Biochemistry. 44 (47): 15544–9. doi:10.1021/bi051494l. PMID 16300403.

AG 489

References

See also

External links