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Platelet transfusion
From WikEM
(Redirected from Platelets)
Contents
General
- Type: Blood products
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Thrombocytopenia
- 1 unit raises count by 50K
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
Platelet Transfusion Thresholds
most if not all of the following thresholds are based on weak recommendations with low quality evidence[1]
- <50K if planned lumbar puncture or neurosurgical procedure
- <20K if planned for central venous catheter placement (preference toward compressible site), or febrile patient
- <10K in asymptomatic patients (unless due to ITP, TTP, or HIT)
There are no firm recommendations for transfusion thresholds in acute traumatic bleeding but many providers will opt for a goal of 100K, especially if there is evidence of ICH
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Comments
- Transfusion should be type specific because platelets are bathed in plasma
- Non-type specific platelets can be used but results in higher rate of complications
- Like pRBCs, platelets can be leukocyte reduced or washed
- A 6-pack of platelets will raise the count by 40,000 to 60,000[2]
See Also
References
- ↑ Kaufman, R. et al. Platelet Transfusion: A Clinical Practice Guideline From the AABB. Annals of Internal Medicine. 2015. Vol 162. No. 3 205-214 Full Text
- ↑ Osterman JL and Arora S. Blood product transfusions and reactions. Emerg Med Clin North Am. 2014; 32(3):727-738.
