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Chlorate toxicity
From WikEM
Revision as of 23:09, 5 April 2017 by Bisakson (Talk | contribs) (Created page with "==Background== *Potassium Chlorate, Barium Chlorate, and Sodium Chlorate are still in use today *Fireworks, match heads, and weed killers ==Mechanism of Toxicity== *Oxidizers...")
Contents
Background
- Potassium Chlorate, Barium Chlorate, and Sodium Chlorate are still in use today
- Fireworks, match heads, and weed killers
Mechanism of Toxicity
- Oxidizers and attackers of sulfhydryl groups
- Cause methemoglobin formation
Clinical Presentation
- Abdominal Pain
- Vomiting
- Diarrhea
- Methemoglobinemia
- Coagulopathy
Diagnosis
- Based on clinical history and presence of methemoglobinemia
- No specific levels are available
Management
- Activated charcoal IS recommended
- Methylene Blue for methemoglobinemia (1-2 mg/kg of 1% solution)
- Sodium Thiosulfate IV may inactivate chlorate ions (anecdotal)
- Hemodialysis
- Supportive Care
External Links
References
Olson, K. Poisoning and Drug Overdose, 1999.
